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    Dnai1 dynein axonemal intermediate chain 1 [ Mus musculus (house mouse) ]

    Gene ID: 68922, updated on 9-Dec-2024

    Summary

    Official Symbol
    Dnai1provided by MGI
    Official Full Name
    dynein axonemal intermediate chain 1provided by MGI
    Primary source
    MGI:MGI:1916172
    See related
    Ensembl:ENSMUSG00000061322 AllianceGenome:MGI:1916172
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Dnaic1; b2b1526Clo; 1110066F04Rik
    Summary
    Predicted to enable dynein heavy chain binding activity and dynein light chain binding activity. Involved in insulin receptor signaling pathway. Acts upstream of or within determination of left/right symmetry; epithelial cilium movement involved in extracellular fluid movement; and heart development. Located in 9+2 motile cilium; centrosome; and cytoplasm. Is expressed in embryo; spermatozoon; and testis. Used to study Kartagener syndrome; primary ciliary dyskinesia 1; and visceral heterotaxy. Human ortholog(s) of this gene implicated in Kartagener syndrome and primary ciliary dyskinesia 1. Orthologous to human DNAI1 (dynein axonemal intermediate chain 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in testis adult (RPKM 28.5), bladder adult (RPKM 10.6) and 5 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Dnai1 in Genome Data Viewer
    Location:
    4 A5; 4 21.75 cM
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (41569731..41638158)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (41569647..41638158)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene family with sequence similarity 219, member A, opposite strand Neighboring gene family with sequence similarity 219, member A Neighboring gene predicted gene 12404 Neighboring gene STARR-positive B cell enhancer ABC_E659 Neighboring gene STARR-seq mESC enhancer starr_10035 Neighboring gene predicted gene 12405 Neighboring gene energy homeostasis associated Neighboring gene ciliary neurotrophic factor receptor Neighboring gene STARR-seq mESC enhancer starr_10037

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables dynein heavy chain binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables dynein light chain binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in 9+2 motile cilium IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in centrosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cilium ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
     
    located_in glial cell projection IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in microtubule IEA
    Inferred from Electronic Annotation
    more info
     
    part_of outer dynein arm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of outer dynein arm IEA
    Inferred from Electronic Annotation
    more info
     
    part_of outer dynein arm ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    dynein axonemal intermediate chain 1
    Names
    axonemal dynein intermediate chain 1
    dynein intermediate chain 1, axonemal

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_175138.4NP_780347.2  dynein axonemal intermediate chain 1

      See identical proteins and their annotated locations for NP_780347.2

      Status: VALIDATED

      Source sequence(s)
      AK047808, CD775688
      Consensus CDS
      CCDS18066.1
      UniProtKB/Swiss-Prot
      Q8BKY5, Q8C0M8
      UniProtKB/TrEMBL
      A2ANP4
      Related
      ENSMUSP00000100028.4, ENSMUST00000102963.10
      Conserved Domains (3) summary
      COG2319
      Location:321679
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:336382
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:354612
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      41569731..41638158
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036164398.1XP_036020291.1  dynein axonemal intermediate chain 1 isoform X1

      Conserved Domains (2) summary
      COG2319
      Location:143501
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:158204
      7WD40; WD40 repeat [structural motif]

    RNA

    1. XR_390339.5 RNA Sequence

    2. XR_390340.5 RNA Sequence