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    Ceacam10 CEA cell adhesion molecule 10 [ Mus musculus (house mouse) ]

    Gene ID: 26366, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Ceacam10provided by MGI
    Official Full Name
    CEA cell adhesion molecule 10provided by MGI
    Primary source
    MGI:MGI:1347248
    See related
    Ensembl:ENSMUSG00000054169 AllianceGenome:MGI:1347248
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Bgp3; Cea10
    Summary
    Predicted to enable protein tyrosine kinase binding activity. Predicted to be involved in regulation of immune system process and signal transduction. Predicted to be located in extracellular region. Predicted to be active in cell surface and plasma membrane. Is expressed in several structures, including alimentary system; immune system; reproductive system; and submandibular gland primordium. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in genital fat pad adult (RPKM 164.8), colon adult (RPKM 46.0) and 3 other tissues See more
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    Genomic context

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    See Ceacam10 in Genome Data Viewer
    Location:
    7 A3; 7 12.78 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (24476592..24484081)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (24777167..24784656)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_18276 Neighboring gene Ly6/PLAUR domain containing 11 Neighboring gene CD177 antigen Neighboring gene STARR-seq mESC enhancer starr_18277 Neighboring gene STARR-seq mESC enhancer starr_18278 Neighboring gene predicted gene 5893 Neighboring gene STARR-seq mESC enhancer starr_18280 Neighboring gene predicted gene, 38965

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. A carcinoembryonic antigen family cDNA from mouse placenta encoding a protein with a rare domain composition. Kataoka K, et al. Placenta, 2000 Sep. PMID 10985962
    2. Demonstration of a glycoprotein derived from the Ceacam10 gene in mouse seminal vesicle secretions. Li SH, et al. Biol Reprod, 2005 Sep. PMID 15901639, Free PMC Article
    3. The cea10 gene encodes a secreted member of the murine carcinoembryonic antigen family and is expressed in the placenta, gastrointestinal tract and bone marrow. Keck U, et al. Eur J Biochem, 1995 Apr 15. PMID 7744068
    4. Increased osteoclastogenesis in mice lacking the carcinoembryonic antigen-related cell adhesion molecule 1. Heckt T, et al. PLoS One, 2014. PMID 25490771, Free PMC Article
    5. Carcinoembryonic antigen-related cell adhesion molecule 10 expressed specifically early in pregnancy in the decidua is dispensable for normal murine development. Finkenzeller D, et al. Mol Cell Biol, 2003 Jan. PMID 12482980, Free PMC Article

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The purification and physiological role of CEACAM10 in male mice is reported. [CEACAM]
      Title: Demonstration of a glycoprotein derived from the Ceacam10 gene in mouse seminal vesicle secretions.
    2. Taken together, both Ceacam10 and Ceacam9, alone or in combination, are not essential for either murine placental and embryonic development or for adult life.
      Title: Carcinoembryonic antigen-related cell adhesion molecule 10 expressed specifically early in pregnancy in the decidua is dispensable for normal murine development.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (2)  1 citation

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein tyrosine kinase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of immune system process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cell surface IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    cell adhesion molecule CEACAM10; carcinoembryonic antigen-related cell adhesion molecule 10
    Names
    CEA-related cell adhesion molecule 10
    carcinoembryonic antigen 10

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001374785.1 → NP_001361714.1  cell adhesion molecule CEACAM10 isoform 2 precursor

      Status: VALIDATED

      Source sequence(s)
      AC161488
      Consensus CDS
      CCDS90181.1
      UniProtKB/TrEMBL
      A0A0U1RQ24
      Related
      ENSMUSP00000146217.2, ENSMUST00000206847.2
      Conserved Domains (1) summary
      cd05774
      Location:36 → 140
      Ig_CEACAM_D1; First immunoglobulin (Ig)-like domain of carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM)

    2. NM_007675.4 → NP_031701.3  cell adhesion molecule CEACAM10 isoform 1 precursor

      See identical proteins and their annotated locations for NP_031701.3

      Status: VALIDATED

      Source sequence(s)
      AC161488, AK018529, BE949028
      Consensus CDS
      CCDS39833.1
      UniProtKB/Swiss-Prot
      Q61400, Q99LD6, Q9D329
      UniProtKB/TrEMBL
      A0A0R4J0G1
      Related
      ENSMUSP00000037036.8, ENSMUST00000038069.9
      Conserved Domains (1) summary
      cd05774
      Location:36 → 140
      Ig_CEACAM_D1; First immunoglobulin (Ig)-like domain of carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      24476592..24484081
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030242605.2 → XP_030098465.1  carcinoembryonic antigen-related cell adhesion molecule 10 isoform X1

      Conserved Domains (1) summary
      cd05774
      Location:32 → 136
      Ig_CEACAM_D1; First immunoglobulin (Ig)-like domain of carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q61400.1 GenPept UniProtKB/Swiss-Prot:Q61400

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