Tnrc6a trinucleotide repeat containing 6a [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Tnrc6aprovided by MGI
Official Full Name: trinucleotide repeat containing 6aprovided by MGI
Primary source: MGI:MGI:2385292
See related: Ensembl:ENSMUSG00000052707 AllianceGenome:MGI:2385292
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: GW182; Tnrc6; CAGH26; 2010321I05Rik; 3110054G10Rik; D130023A07Rik
Summary: This gene encodes a member of the trinucleotide repeat containing 6 protein family. The protein is highly similar to a human protein that functions in post-transcriptional gene silencing through the RNA interference (RNAi) and microRNA pathways. The human protein associates with messenger RNAs and argonaute proteins in cytoplasmic bodies known as GW-bodies or P-bodies, and inhibiting its expression delocalizes other GW-body proteins and impairs RNAi and microRNA-induced gene silencing. [provided by RefSeq, Jul 2008]
Expression: Ubiquitous expression in CNS E11.5 (RPKM 14.3), CNS E14 (RPKM 13.5) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 7 F2- F3; 7 67.42 cM

Exon count:: 30

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	7	NC_000073.7 (122630324..122794519)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	7	NC_000073.6 (123031101..123195296)

Chromosome 7 - NC_000073.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

GW182 is an essential functional component in the RNA-induced silencing complex for miRNA-mediated gene silencing in vivo
Title: Trinucleotide repeat containing 6a (Tnrc6a)-mediated microRNA function is required for development of yolk sac endoderm.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Gene trapped (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Tnrc6a (e-PCR), detects polymorphism
- UniSTS:479296

Tnrc6a (e-PCR), detects polymorphism
- UniSTS:547162

L17913 (e-PCR)
- UniSTS:60532

AW557223 (e-PCR)
- UniSTS:179643

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables RNA binding	IEA Inferred from Electronic Annotation more info
enables molecular adaptor activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed

Process	Evidence Code	Pubs
involved_in P-body assembly	IEA Inferred from Electronic Annotation more info
involved_in P-body assembly	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cellular response to starvation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within endoderm development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within maintenance of protein location in cell	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in miRNA-mediated gene silencing by inhibition of translation	ISO Inferred from Sequence Orthology more info
involved_in miRNA-mediated gene silencing by inhibition of translation	ISS Inferred from Sequence or Structural Similarity more info
involved_in miRNA-mediated post-transcriptional gene silencing	IBA Inferred from Biological aspect of Ancestor more info
involved_in miRNA-mediated post-transcriptional gene silencing	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of nuclear-transcribed mRNA poly(A) tail shortening	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of nuclear-transcribed mRNA poly(A) tail shortening	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulatory ncRNA-mediated gene silencing	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in Golgi apparatus	IEA Inferred from Electronic Annotation more info
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
is_active_in P-body	IBA Inferred from Biological aspect of Ancestor more info
is_active_in P-body	ISO Inferred from Sequence Orthology more info
located_in P-body	ISO Inferred from Sequence Orthology more info
located_in P-body	ISS Inferred from Sequence or Structural Similarity more info	PubMed
part_of RISC complex	ISO Inferred from Sequence Orthology more info
part_of RISC complex	ISS Inferred from Sequence or Structural Similarity more info
located_in cytosol	TAS Traceable Author Statement more info
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info
is_active_in nucleoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in perinuclear region of cytoplasm	ISS Inferred from Sequence or Structural Similarity more info	PubMed

General protein information

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Preferred Names: trinucleotide repeat-containing gene 6A protein

Names: GW182 autoantigen

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_144925.3 → NP_659174.3 trinucleotide repeat-containing gene 6A protein

Status: VALIDATED

Source sequence(s)

AC138364, AK147327, BF020619, BY720212, CD802917

Consensus CDS

CCDS57583.1

UniProtKB/Swiss-Prot

F6ZMJ4, Q3UHK8

Related

ENSMUSP00000091595.6, ENSMUST00000094053.7

Conserved Domains (4) summary

cd12711
Location:1715 → 1797

RRM_TNRC6A; RNA recognition motif in vertebrate GW182 autoantigen

pfam10427
Location:1060 → 1185

Ago_hook; Argonaute hook

pfam12938
Location:1266 → 1416

M_domain; M domain of GW182

pfam16608
Location:1439 → 1702

TNRC6-PABC_bdg; TNRC6-PABC binding domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000073.7 Reference GRCm39 C57BL/6J

Range

122630324..122794519

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_011241757.1 → XP_011240059.1 trinucleotide repeat-containing gene 6A protein isoform X1

Conserved Domains (4) summary

cd12711
Location:1773 → 1855

RRM_TNRC6A; RNA recognition motif in vertebrate GW182 autoantigen

pfam10427
Location:1069 → 1194

Ago_hook; Argonaute hook

pfam12938
Location:1289 → 1474

M_domain; M domain of GW182

pfam16608
Location:1497 → 1760

TNRC6-PABC_bdg; TNRC6-PABC binding domain
XM_017322202.1 → XP_017177691.1 trinucleotide repeat-containing gene 6A protein isoform X6

Conserved Domains (4) summary

cd12711
Location:1773 → 1855

RRM_TNRC6A; RNA recognition motif in vertebrate GW182 autoantigen

pfam10427
Location:1069 → 1194

Ago_hook; Argonaute hook

pfam12938
Location:1289 → 1474

M_domain; M domain of GW182

pfam16608
Location:1497 → 1760

TNRC6-PABC_bdg; TNRC6-PABC binding domain
XM_011241760.2 → XP_011240062.1 trinucleotide repeat-containing gene 6A protein isoform X5

Conserved Domains (4) summary

cd12711
Location:1750 → 1832

RRM_TNRC6A; RNA recognition motif in vertebrate GW182 autoantigen

pfam10427
Location:1069 → 1194

Ago_hook; Argonaute hook

pfam12938
Location:1289 → 1378

M_domain; M domain of GW182

pfam16608
Location:1474 → 1737

TNRC6-PABC_bdg; TNRC6-PABC binding domain
XM_011241762.2 → XP_011240064.1 trinucleotide repeat-containing gene 6A protein isoform X7

Conserved Domains (4) summary

cd12711
Location:1724 → 1806

RRM_TNRC6A; RNA recognition motif in vertebrate GW182 autoantigen

pfam10427
Location:1069 → 1194

Ago_hook; Argonaute hook

pfam12938
Location:1275 → 1425

M_domain; M domain of GW182

pfam16608
Location:1448 → 1711

TNRC6-PABC_bdg; TNRC6-PABC binding domain
XM_017322203.2 → XP_017177692.1 trinucleotide repeat-containing gene 6A protein isoform X10

Conserved Domains (4) summary

cd12711
Location:1701 → 1783

RRM_TNRC6A; RNA recognition motif in vertebrate GW182 autoantigen

pfam10427
Location:1069 → 1194

Ago_hook; Argonaute hook

pfam12938
Location:1275 → 1329

M_domain; M domain of GW182

pfam16608
Location:1425 → 1688

TNRC6-PABC_bdg; TNRC6-PABC binding domain
XM_011241758.2 → XP_011240060.1 trinucleotide repeat-containing gene 6A protein isoform X3

Conserved Domains (4) summary

cd12711
Location:1762 → 1844

RRM_TNRC6A; RNA recognition motif in vertebrate GW182 autoantigen

pfam10427
Location:1069 → 1183

Ago_hook; Argonaute hook

pfam12938
Location:1278 → 1463

M_domain; M domain of GW182

pfam16608
Location:1486 → 1749

TNRC6-PABC_bdg; TNRC6-PABC binding domain
XM_011241763.2 → XP_011240065.1 trinucleotide repeat-containing gene 6A protein isoform X9

Conserved Domains (4) summary

cd12711
Location:1713 → 1795

RRM_TNRC6A; RNA recognition motif in vertebrate GW182 autoantigen

pfam10427
Location:1069 → 1183

Ago_hook; Argonaute hook

pfam12938
Location:1264 → 1414

M_domain; M domain of GW182

pfam16608
Location:1437 → 1700

TNRC6-PABC_bdg; TNRC6-PABC binding domain
XM_036153008.1 → XP_036008901.1 trinucleotide repeat-containing gene 6A protein isoform X12

Conserved Domains (5) summary

pfam10427
Location:1069 → 1183

Ago_hook; Argonaute hook

pfam12938
Location:1264 → 1318

M_domain; M domain of GW182

pfam16608
Location:1416 → 1677

TNRC6-PABC_bdg; TNRC6-PABC binding domain

cd12711
Location:1685 → 1776

RRM_TNRC6A; RNA recognition motif (RRM) found in vertebrate GW182 autoantigen

NF033849
Location:596 → 854

ser_rich_anae_1; serine-rich protein
XM_011241764.2 → XP_011240066.1 trinucleotide repeat-containing gene 6A protein isoform X15

Conserved Domains (2) summary

pfam10427
Location:1069 → 1194

Ago_hook; Argonaute hook

pfam12938
Location:1289 → 1361

M_domain; M domain of GW182
XM_011241765.3 → XP_011240067.1 trinucleotide repeat-containing gene 6A protein isoform X16

UniProtKB/TrEMBL

Q05CE3

Conserved Domains (1) summary

pfam10427
Location:1069 → 1161

Ago_hook; Argonaute hook
XM_006507705.3 → XP_006507768.1 trinucleotide repeat-containing gene 6A protein isoform X2

Conserved Domains (4) summary

cd12711
Location:1764 → 1846

RRM_TNRC6A; RNA recognition motif in vertebrate GW182 autoantigen

pfam10427
Location:1060 → 1185

Ago_hook; Argonaute hook

pfam12938
Location:1280 → 1465

M_domain; M domain of GW182

pfam16608
Location:1488 → 1751

TNRC6-PABC_bdg; TNRC6-PABC binding domain
XM_017322204.3 → XP_017177693.1 trinucleotide repeat-containing gene 6A protein isoform X11

Conserved Domains (4) summary

cd12711
Location:1692 → 1774

RRM_TNRC6A; RNA recognition motif in vertebrate GW182 autoantigen

pfam10427
Location:1060 → 1185

Ago_hook; Argonaute hook

pfam12938
Location:1266 → 1320

M_domain; M domain of GW182

pfam16608
Location:1416 → 1679

TNRC6-PABC_bdg; TNRC6-PABC binding domain
XM_017322201.3 → XP_017177690.1 trinucleotide repeat-containing gene 6A protein isoform X4

Conserved Domains (4) summary

cd12711
Location:1753 → 1835

RRM_TNRC6A; RNA recognition motif in vertebrate GW182 autoantigen

pfam10427
Location:1060 → 1174

Ago_hook; Argonaute hook

pfam12938
Location:1269 → 1454

M_domain; M domain of GW182

pfam16608
Location:1477 → 1740

TNRC6-PABC_bdg; TNRC6-PABC binding domain
XM_017322205.3 → XP_017177694.1 trinucleotide repeat-containing gene 6A protein isoform X13

UniProtKB/TrEMBL

A0A0U1RQ65

Conserved Domains (4) summary

cd12711
Location:1509 → 1591

RRM_TNRC6A; RNA recognition motif in vertebrate GW182 autoantigen

pfam10427
Location:805 → 930

Ago_hook; Argonaute hook

pfam12938
Location:1025 → 1210

M_domain; M domain of GW182

pfam16608
Location:1233 → 1496

TNRC6-PABC_bdg; TNRC6-PABC binding domain
XM_036153009.1 → XP_036008902.1 trinucleotide repeat-containing gene 6A protein isoform X14

UniProtKB/TrEMBL

A0A0U1RQ65

Conserved Domains (5) summary

pfam10427
Location:805 → 930

Ago_hook; Argonaute hook

pfam12938
Location:1011 → 1161

M_domain; M domain of GW182

pfam16608
Location:1186 → 1447

TNRC6-PABC_bdg; TNRC6-PABC binding domain

cd12711
Location:1455 → 1546

RRM_TNRC6A; RNA recognition motif (RRM) found in vertebrate GW182 autoantigen

NF033849
Location:332 → 590

ser_rich_anae_1; serine-rich protein
XM_017322206.3 → XP_017177695.1 trinucleotide repeat-containing gene 6A protein isoform X13

UniProtKB/TrEMBL

A0A0U1RQ65

Related

ENSMUSP00000146266.2, ENSMUST00000205760.2

Conserved Domains (4) summary

cd12711
Location:1509 → 1591

RRM_TNRC6A; RNA recognition motif in vertebrate GW182 autoantigen

pfam10427
Location:805 → 930

Ago_hook; Argonaute hook

pfam12938
Location:1025 → 1210

M_domain; M domain of GW182

pfam16608
Location:1233 → 1496

TNRC6-PABC_bdg; TNRC6-PABC binding domain
XM_036153010.1 → XP_036008903.1 trinucleotide repeat-containing gene 6A protein isoform X14

UniProtKB/TrEMBL

A0A0U1RQ65

Conserved Domains (5) summary

pfam10427
Location:805 → 930

Ago_hook; Argonaute hook

pfam12938
Location:1011 → 1161

M_domain; M domain of GW182

pfam16608
Location:1186 → 1447

TNRC6-PABC_bdg; TNRC6-PABC binding domain

cd12711
Location:1455 → 1546

RRM_TNRC6A; RNA recognition motif (RRM) found in vertebrate GW182 autoantigen

NF033849
Location:332 → 590

ser_rich_anae_1; serine-rich protein
XM_036153007.1 → XP_036008900.1 trinucleotide repeat-containing gene 6A protein isoform X8

Conserved Domains (5) summary

pfam10427
Location:1016 → 1141

Ago_hook; Argonaute hook

pfam12938
Location:1236 → 1421

M_domain; M domain of GW182

pfam16608
Location:1446 → 1707

TNRC6-PABC_bdg; TNRC6-PABC binding domain

cd12711
Location:1715 → 1806

RRM_TNRC6A; RNA recognition motif (RRM) found in vertebrate GW182 autoantigen

NF033849
Location:543 → 801

ser_rich_anae_1; serine-rich protein