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    RGC1 Rgc1p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 856231, updated on 9-Dec-2024

    Summary

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    Official Symbol
    RGC1
    Official Full Name
    Rgc1p
    Primary source
    SGD:S000006319
    Locus tag
    YPR115W
    See related
    AllianceGenome:SGD:S000006319; FungiDB:YPR115W; VEuPathDB:YPR115W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Predicted to enable channel regulator activity. Involved in positive regulation of glycerol transport. Located in cytoplasm. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See RGC1 in Genome Data Viewer
    Location:
    chromosome: XVI
    Exon count:
    1
    Sequence:
    Chromosome: XVI; NC_001148.4 (754877..758128)

    Chromosome XVI - NC_001148.4Genomic Context describing neighboring genes Neighboring gene CDP-diacylglycerol--inositol 3-phosphatidyltransferase Neighboring gene uncharacterized protein Neighboring gene Rrg8p Neighboring gene Hob2p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001148.4

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Yeast Fps1 glycerol facilitator functions as a homotetramer. Beese-Sims SE, et al. Yeast, 2011 Dec. PMID 22030956, Free PMC Article
    2. Rgc2 Regulator of Glycerol Channel Fps1 Functions as a Homo- and Heterodimer with Rgc1. Lee J, et al. Eukaryot Cell, 2015 Jul. PMID 26024902, Free PMC Article
    3. Identification of positive regulators of the yeast fps1 glycerol channel. Beese SE, et al. PLoS Genet, 2009 Nov. PMID 19956799, Free PMC Article
    4. MAPK Hog1 closes the S. cerevisiae glycerol channel Fps1 by phosphorylating and displacing its positive regulators. Lee J, et al. Genes Dev, 2013 Dec 1. PMID 24298058, Free PMC Article
    5. Mapping protein-protein interactions for the yeast ABC transporter Ycf1p by integrated split-ubiquitin membrane yeast two-hybrid analysis. Paumi CM, et al. Mol Cell, 2007 Apr 13. PMID 17434123

    See all (50) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables channel regulator activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in actin cytoskeleton organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of glycerol transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm HDA PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Rgc1p
    NP_015440.1
    • Putative regulator of the Fps1p glycerol channel; multiply phosphorylated by Hog1p under osmotic stress; contains a pleckstrin homology domain; forms homodimers and heterodimerizes with paralog Ask10p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001148.4 Reference assembly

      Range
      754877..758128
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001184212.1 → NP_015440.1  TPA: Rgc1p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_015440.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W4B4, Q06108
      UniProtKB/TrEMBL
      A6ZWZ6, B3LK79, C8ZJD7, N1NWG4
      Conserved Domains (1) summary
      cl17171
      Location:496 → 535
      PH-like; Pleckstrin homology-like domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q06108.1

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