Pwwp3a PWWP domain containing 3A, DNA repair factor [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Pwwp3aprovided by MGI
Official Full Name: PWWP domain containing 3A, DNA repair factorprovided by MGI
Primary source: MGI:MGI:1915364
See related: Ensembl:ENSMUSG00000020156 AllianceGenome:MGI:1915364
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Mum1; MUM-1; UBE-1C2; 2610019J09; 9430059D04Rik
Summary: Predicted to enable nucleosome binding activity. Predicted to be involved in DNA repair and chromatin organization. Predicted to be located in nucleoplasm. Predicted to be active in cytosol and nucleus. Is expressed in several structures, including foregut; ganglia; midbrain lateral wall; nose; and tooth. Orthologous to human PWWP3A (PWWP domain containing 3A, DNA repair factor). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Ubiquitous expression in testis adult (RPKM 52.6), CNS E11.5 (RPKM 26.1) and 26 other tissues See more
Orthologs: human all
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Genomic context

Location:: 10 C1; 10 39.72 cM

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	10	NC_000076.7 (80062265..80082415)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	10	NC_000076.6 (80226431..80245144)

Chromosome 10 - NC_000076.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3)

General gene information

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Markers

D9Mit34.1 (e-PCR), detects polymorphism
- UniSTS:131903

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables nucleosome binding	IBA Inferred from Biological aspect of Ancestor more info
enables nucleosome binding	ISO Inferred from Sequence Orthology more info
enables nucleosome binding	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in DNA repair	IBA Inferred from Biological aspect of Ancestor more info
involved_in DNA repair	ISO Inferred from Sequence Orthology more info
involved_in DNA repair	ISS Inferred from Sequence or Structural Similarity more info
involved_in chromatin organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in chromatin organization	ISO Inferred from Sequence Orthology more info
involved_in chromatin organization	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: PWWP domain-containing DNA repair factor 3A

Names: PWWP domain-containing protein MUM1; melanoma associated antigen (mutated) 1; mutated melanoma-associated antigen 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_023431.6 → NP_075920.4 PWWP domain-containing DNA repair factor 3A

See identical proteins and their annotated locations for NP_075920.4

Status: VALIDATED

Source sequence(s)

AC140229

Consensus CDS

CCDS24014.1

UniProtKB/Swiss-Prot

Q3TCZ4, Q6DID5, Q6NST9, Q8C5E3, Q8R1V6, Q9R1R7

Related

ENSMUSP00000020365.9, ENSMUST00000020365.15

Conserved Domains (1) summary

cd06080
Location:381 → 460

MUM1_like; Mutated melanoma-associated antigen 1 (MUM-1) is a melanoma-associated antigen (MAA). MUM-1 belongs to the mutated or aberrantly expressed type of MAAs, along with antigens such as CDK4, beta-catenin, gp100-in4, p15, and N-acetylglucosaminyltransferase ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000076.7 Reference GRCm39 C57BL/6J

Range

80062265..80082415

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_030245246.1 → XP_030101106.1 PWWP domain-containing DNA repair factor 3A isoform X1

UniProtKB/Swiss-Prot

Q3TCZ4, Q6DID5, Q6NST9, Q8C5E3, Q8R1V6, Q9R1R7

Conserved Domains (1) summary

cd06080
Location:381 → 460

MUM1_like; Mutated melanoma-associated antigen 1 (MUM-1) is a melanoma-associated antigen (MAA). MUM-1 belongs to the mutated or aberrantly expressed type of MAAs, along with antigens such as CDK4, beta-catenin, gp100-in4, p15, and N-acetylglucosaminyltransferase ...
XM_006514026.2 → XP_006514089.1 PWWP domain-containing DNA repair factor 3A isoform X2

Conserved Domains (1) summary

cd06080
Location:381 → 460

MUM1_like; Mutated melanoma-associated antigen 1 (MUM-1) is a melanoma-associated antigen (MAA). MUM-1 belongs to the mutated or aberrantly expressed type of MAAs, along with antigens such as CDK4, beta-catenin, gp100-in4, p15, and N-acetylglucosaminyltransferase ...
XM_006514025.3 → XP_006514088.1 PWWP domain-containing DNA repair factor 3A isoform X1

See identical proteins and their annotated locations for XP_006514088.1

UniProtKB/Swiss-Prot

Q3TCZ4, Q6DID5, Q6NST9, Q8C5E3, Q8R1V6, Q9R1R7

Conserved Domains (1) summary

cd06080
Location:381 → 460

MUM1_like; Mutated melanoma-associated antigen 1 (MUM-1) is a melanoma-associated antigen (MAA). MUM-1 belongs to the mutated or aberrantly expressed type of MAAs, along with antigens such as CDK4, beta-catenin, gp100-in4, p15, and N-acetylglucosaminyltransferase ...