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    Ralgps2 Ral GEF with PH domain and SH3 binding motif 2 [ Mus musculus (house mouse) ]

    Gene ID: 78255, updated on 9-Dec-2024

    Summary

    Official Symbol
    Ralgps2provided by MGI
    Official Full Name
    Ral GEF with PH domain and SH3 binding motif 2provided by MGI
    Primary source
    MGI:MGI:1925505
    See related
    Ensembl:ENSMUSG00000026594 AllianceGenome:MGI:1925505
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    1810020P17Rik; 2210408F11Rik; 4921528G01Rik; 9130014M22Rik
    Summary
    Predicted to enable guanyl-nucleotide exchange factor activity. Predicted to be involved in Ras protein signal transduction. Predicted to be located in cytoplasm. Predicted to be active in plasma membrane. Is expressed in several structures, including alimentary system; eye; limb bud; limb segment; and nervous system. Orthologous to human RALGPS2 (Ral GEF with PH domain and SH3 binding motif 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in testis adult (RPKM 13.7), CNS E14 (RPKM 8.2) and 27 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Ralgps2 in Genome Data Viewer
    Location:
    1 G3; 1 67.71 cM
    Exon count:
    28
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (156631736..156767422, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (156804166..156939850, complement)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer mm9_chr1:158682524-158682825 Neighboring gene predicted gene, 39683 Neighboring gene PCNA-associated factor pseudogene Neighboring gene angiopoietin-like 1 Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:158834070-158834253 Neighboring gene STARR-positive B cell enhancer ABC_E2572 Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:158863932-158864133 Neighboring gene RIKEN cDNA 4930439D14 gene Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:158868943-158869130 Neighboring gene STARR-positive B cell enhancer ABC_E9487 Neighboring gene STARR-seq mESC enhancer starr_02758 Neighboring gene STARR-positive B cell enhancer ABC_E5828 Neighboring gene STARR-positive B cell enhancer ABC_E4364 Neighboring gene STARR-seq mESC enhancer starr_02759 Neighboring gene STARR-positive B cell enhancer ABC_E2573 Neighboring gene STARR-positive B cell enhancer ABC_E3318 Neighboring gene predicted gene, 39685 Neighboring gene STARR-positive B cell enhancer ABC_E1569 Neighboring gene STARR-positive B cell enhancer mm9_chr1:158957909-158958210 Neighboring gene STARR-seq mESC enhancer starr_02761 Neighboring gene STARR-positive B cell enhancer ABC_E7762 Neighboring gene STARR-positive B cell enhancer ABC_E1232 Neighboring gene STARR-seq mESC enhancer starr_02762 Neighboring gene STARR-positive B cell enhancer ABC_E7763 Neighboring gene predicted gene, 30568

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (1) 

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables guanyl-nucleotide exchange factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables guanyl-nucleotide exchange factor activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in Ras protein signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in small GTPase-mediated signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    ras-specific guanine nucleotide-releasing factor RalGPS2
    Names
    ral GEF with PH domain and SH3-binding motif 2
    ralA exchange factor RalGPS2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001159965.1NP_001153437.1  ras-specific guanine nucleotide-releasing factor RalGPS2 isoform a

      See identical proteins and their annotated locations for NP_001153437.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the predominant transcript and encodes the longest isoform (a). Variants 1, 2, and 3 all encode isoform a.
      Source sequence(s)
      AC138109, AK019543, AK033549, BC052663, CJ104104
      Consensus CDS
      CCDS15396.1
      UniProtKB/Swiss-Prot
      Q7TPZ6, Q80YA6, Q8BZ37, Q8BZU2, Q9D2Y7, Q9ERD6
      UniProtKB/TrEMBL
      Q8C134
      Related
      ENSMUSP00000063872.7, ENSMUST00000063199.13
      Conserved Domains (2) summary
      smart00147
      Location:45286
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
      cd13310
      Location:466581
      PH_RalGPS1_2; Ral GEF with PH domain and SH3 binding motif 1 and 2 Pleckstrin homology (PH) domain
    2. NM_001159966.1NP_001153438.1  ras-specific guanine nucleotide-releasing factor RalGPS2 isoform a

      See identical proteins and their annotated locations for NP_001153438.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2, and 3 all encode isoform a.
      Source sequence(s)
      AC138109, AK019543, AK033549
      Consensus CDS
      CCDS15396.1
      UniProtKB/Swiss-Prot
      Q7TPZ6, Q80YA6, Q8BZ37, Q8BZU2, Q9D2Y7, Q9ERD6
      UniProtKB/TrEMBL
      Q8C134
      Related
      ENSMUSP00000130581.2, ENSMUST00000171292.8
      Conserved Domains (2) summary
      smart00147
      Location:45286
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
      cd13310
      Location:466581
      PH_RalGPS1_2; Ral GEF with PH domain and SH3 binding motif 1 and 2 Pleckstrin homology (PH) domain
    3. NM_001159967.1NP_001153439.1  ras-specific guanine nucleotide-releasing factor RalGPS2 isoform b

      See identical proteins and their annotated locations for NP_001153439.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (b) has the same N- and C-termini but is shorter compared to isoform a.
      Source sequence(s)
      AC138109, AK169368, CJ104104
      Consensus CDS
      CCDS48406.1
      UniProtKB/TrEMBL
      Q8C134
      Related
      ENSMUSP00000027886.8, ENSMUST00000027886.14
      Conserved Domains (2) summary
      smart00147
      Location:45286
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
      cd13310
      Location:440555
      PH_RalGPS1_2; Ral GEF with PH domain and SH3 binding motif 1 and 2 Pleckstrin homology (PH) domain
    4. NM_001159968.1NP_001153440.1  ras-specific guanine nucleotide-releasing factor RalGPS2 isoform c

      See identical proteins and their annotated locations for NP_001153440.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (c) has the same N- and C-termini but is shorter compared to isoform a.
      Source sequence(s)
      AC138109, AK036803, CJ104104
      Consensus CDS
      CCDS48405.1
      UniProtKB/TrEMBL
      Q8C134
      Related
      ENSMUSP00000132533.2, ENSMUST00000172057.8
      Conserved Domains (3) summary
      smart00147
      Location:21251
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
      cd13310
      Location:431546
      PH_RalGPS1_2; Ral GEF with PH domain and SH3 binding motif 1 and 2 Pleckstrin homology (PH) domain
      pfam00169
      Location:430540
      PH; PH domain
    5. NM_001357391.1NP_001344320.1  ras-specific guanine nucleotide-releasing factor RalGPS2 isoform d

      Status: VALIDATED

      Description
      Transcript Variant: This variant (6) differs in its 5' UTR and uses a downstream in-frame start codon, compared to variant 1. The encoded isoform (d) has a shorter N-terminus compared to isoform a.
      Source sequence(s)
      AC138109
      Conserved Domains (2) summary
      cd13310
      Location:300415
      PH_RalGPS1_2; Ral GEF with PH domain and SH3 binding motif 1 and 2 Pleckstrin homology (PH) domain
      cl02485
      Location:1146
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...
    6. NM_001357392.1NP_001344321.1  ras-specific guanine nucleotide-releasing factor RalGPS2 isoform d

      Status: VALIDATED

      Description
      Transcript Variant: This variant (7) differs in its 5' UTR and uses a downstream in-frame start codon, compared to variant 1. The encoded isoform (d) has a shorter N-terminus compared to isoform a.
      Source sequence(s)
      AC138109
      Conserved Domains (2) summary
      cd13310
      Location:300415
      PH_RalGPS1_2; Ral GEF with PH domain and SH3 binding motif 1 and 2 Pleckstrin homology (PH) domain
      cl02485
      Location:1146
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...
    7. NM_023884.4NP_076373.3  ras-specific guanine nucleotide-releasing factor RalGPS2 isoform a

      See identical proteins and their annotated locations for NP_076373.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2, and 3 all encode isoform a.
      Source sequence(s)
      AC138109, AK019543, AK033549, CJ104104
      Consensus CDS
      CCDS15396.1
      UniProtKB/Swiss-Prot
      Q7TPZ6, Q80YA6, Q8BZ37, Q8BZU2, Q9D2Y7, Q9ERD6
      UniProtKB/TrEMBL
      Q8C134
      Related
      ENSMUSP00000139645.2, ENSMUST00000191605.7
      Conserved Domains (2) summary
      smart00147
      Location:45286
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
      cd13310
      Location:466581
      PH_RalGPS1_2; Ral GEF with PH domain and SH3 binding motif 1 and 2 Pleckstrin homology (PH) domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      156631736..156767422 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030243663.2XP_030099523.1  ras-specific guanine nucleotide-releasing factor RalGPS2 isoform X3

      Conserved Domains (2) summary
      cd13310
      Location:326441
      PH_RalGPS1_2; Ral GEF with PH domain and SH3 binding motif 1 and 2 Pleckstrin homology (PH) domain
      cl02485
      Location:1146
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...
    2. XM_006497033.2XP_006497096.1  ras-specific guanine nucleotide-releasing factor RalGPS2 isoform X3

      Conserved Domains (2) summary
      cd13310
      Location:326441
      PH_RalGPS1_2; Ral GEF with PH domain and SH3 binding motif 1 and 2 Pleckstrin homology (PH) domain
      cl02485
      Location:1146
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...
    3. XM_030243662.1XP_030099522.1  ras-specific guanine nucleotide-releasing factor RalGPS2 isoform X3

      Conserved Domains (2) summary
      cd13310
      Location:326441
      PH_RalGPS1_2; Ral GEF with PH domain and SH3 binding motif 1 and 2 Pleckstrin homology (PH) domain
      cl02485
      Location:1146
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...
    4. XM_030243657.1XP_030099517.1  ras-specific guanine nucleotide-releasing factor RalGPS2 isoform X2

      UniProtKB/TrEMBL
      Q8C134
      Conserved Domains (2) summary
      smart00147
      Location:45286
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
      cd13310
      Location:440555
      PH_RalGPS1_2; Ral GEF with PH domain and SH3 binding motif 1 and 2 Pleckstrin homology (PH) domain
    5. XM_030243660.1XP_030099520.1  ras-specific guanine nucleotide-releasing factor RalGPS2 isoform X2

      UniProtKB/TrEMBL
      Q8C134
      Conserved Domains (2) summary
      smart00147
      Location:45286
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
      cd13310
      Location:440555
      PH_RalGPS1_2; Ral GEF with PH domain and SH3 binding motif 1 and 2 Pleckstrin homology (PH) domain
    6. XM_030243669.1XP_030099529.1  ras-specific guanine nucleotide-releasing factor RalGPS2 isoform X4

      Conserved Domains (2) summary
      cd13310
      Location:300415
      PH_RalGPS1_2; Ral GEF with PH domain and SH3 binding motif 1 and 2 Pleckstrin homology (PH) domain
      cl02485
      Location:1146
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...
    7. XM_030243656.2XP_030099516.1  ras-specific guanine nucleotide-releasing factor RalGPS2 isoform X2

      UniProtKB/TrEMBL
      Q8C134
      Conserved Domains (2) summary
      smart00147
      Location:45286
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
      cd13310
      Location:440555
      PH_RalGPS1_2; Ral GEF with PH domain and SH3 binding motif 1 and 2 Pleckstrin homology (PH) domain
    8. XM_030243664.2XP_030099524.1  ras-specific guanine nucleotide-releasing factor RalGPS2 isoform X3

      Conserved Domains (2) summary
      cd13310
      Location:326441
      PH_RalGPS1_2; Ral GEF with PH domain and SH3 binding motif 1 and 2 Pleckstrin homology (PH) domain
      cl02485
      Location:1146
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...
    9. XM_030243667.1XP_030099527.1  ras-specific guanine nucleotide-releasing factor RalGPS2 isoform X4

      Conserved Domains (2) summary
      cd13310
      Location:300415
      PH_RalGPS1_2; Ral GEF with PH domain and SH3 binding motif 1 and 2 Pleckstrin homology (PH) domain
      cl02485
      Location:1146
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...
    10. XM_036154413.1XP_036010306.1  ras-specific guanine nucleotide-releasing factor RalGPS2 isoform X5

      Conserved Domains (2) summary
      cd13310
      Location:235350
      PH_RalGPS1_2; Ral GEF with PH domain and SH3 binding motif 1 and 2 Pleckstrin homology (PH) domain
      cl02485
      Location:155
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...
    11. XM_006497029.4XP_006497092.1  ras-specific guanine nucleotide-releasing factor RalGPS2 isoform X1

      See identical proteins and their annotated locations for XP_006497092.1

      UniProtKB/Swiss-Prot
      Q7TPZ6, Q80YA6, Q8BZ37, Q8BZU2, Q9D2Y7, Q9ERD6
      UniProtKB/TrEMBL
      Q8C134
      Conserved Domains (2) summary
      smart00147
      Location:45286
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
      cd13310
      Location:466581
      PH_RalGPS1_2; Ral GEF with PH domain and SH3 binding motif 1 and 2 Pleckstrin homology (PH) domain
    12. XM_006497028.5XP_006497091.1  ras-specific guanine nucleotide-releasing factor RalGPS2 isoform X1

      See identical proteins and their annotated locations for XP_006497091.1

      UniProtKB/Swiss-Prot
      Q7TPZ6, Q80YA6, Q8BZ37, Q8BZU2, Q9D2Y7, Q9ERD6
      UniProtKB/TrEMBL
      Q8C134
      Related
      ENSMUSP00000140342.2, ENSMUST00000188656.7
      Conserved Domains (2) summary
      smart00147
      Location:45286
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
      cd13310
      Location:466581
      PH_RalGPS1_2; Ral GEF with PH domain and SH3 binding motif 1 and 2 Pleckstrin homology (PH) domain
    13. XM_006497032.5XP_006497095.1  ras-specific guanine nucleotide-releasing factor RalGPS2 isoform X1

      See identical proteins and their annotated locations for XP_006497095.1

      UniProtKB/Swiss-Prot
      Q7TPZ6, Q80YA6, Q8BZ37, Q8BZU2, Q9D2Y7, Q9ERD6
      UniProtKB/TrEMBL
      Q8C134
      Conserved Domains (2) summary
      smart00147
      Location:45286
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
      cd13310
      Location:466581
      PH_RalGPS1_2; Ral GEF with PH domain and SH3 binding motif 1 and 2 Pleckstrin homology (PH) domain
    14. XM_006497030.4XP_006497093.1  ras-specific guanine nucleotide-releasing factor RalGPS2 isoform X1

      See identical proteins and their annotated locations for XP_006497093.1

      UniProtKB/Swiss-Prot
      Q7TPZ6, Q80YA6, Q8BZ37, Q8BZU2, Q9D2Y7, Q9ERD6
      UniProtKB/TrEMBL
      Q8C134
      Related
      ENSMUSP00000139618.2, ENSMUST00000185198.7
      Conserved Domains (2) summary
      smart00147
      Location:45286
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
      cd13310
      Location:466581
      PH_RalGPS1_2; Ral GEF with PH domain and SH3 binding motif 1 and 2 Pleckstrin homology (PH) domain
    15. XM_006497031.5XP_006497094.1  ras-specific guanine nucleotide-releasing factor RalGPS2 isoform X1

      See identical proteins and their annotated locations for XP_006497094.1

      UniProtKB/Swiss-Prot
      Q7TPZ6, Q80YA6, Q8BZ37, Q8BZU2, Q9D2Y7, Q9ERD6
      UniProtKB/TrEMBL
      Q8C134
      Conserved Domains (2) summary
      smart00147
      Location:45286
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
      cd13310
      Location:466581
      PH_RalGPS1_2; Ral GEF with PH domain and SH3 binding motif 1 and 2 Pleckstrin homology (PH) domain

    RNA

    1. XR_003947313.2 RNA Sequence

    2. XR_373625.4 RNA Sequence