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    Zfand4 zinc finger, AN1-type domain 4 [ Mus musculus (house mouse) ]

    Gene ID: 67492, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Zfand4provided by MGI
    Official Full Name
    zinc finger, AN1-type domain 4provided by MGI
    Primary source
    MGI:MGI:1914742
    See related
    Ensembl:ENSMUSG00000042213 AllianceGenome:MGI:1914742
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Anubl1
    Summary
    Predicted to enable zinc ion binding activity. Is expressed in central nervous system and genitourinary system. Orthologous to human ZFAND4 (zinc finger AN1-type containing 4). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in testis adult (RPKM 15.6), liver E18 (RPKM 1.4) and 7 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Zfand4 in Genome Data Viewer
    Location:
    6 E3; 6 53.77 cM
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (116241046..116310384)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (116263594..116333423)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 9530062K07 gene Neighboring gene WASH complex subunit 2 Neighboring gene predicted gene, 52873 Neighboring gene STARR-positive B cell enhancer ABC_E2799 Neighboring gene STARR-seq mESC enhancer starr_17102 Neighboring gene membrane associated ring-CH-type finger 8 Neighboring gene predicted gene, 23527 Neighboring gene predicted gene, 38880 Neighboring gene arachidonate 5-lipoxygenase

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Targeting a complex transcriptome: the construction of the mouse full-length cDNA encyclopedia. Carninci P, et al. Genome Res, 2003 Jun. PMID 12819125, Free PMC Article
    2. A genome-wide screen to identify transcription factors expressed in pelvic Ganglia of the lower urinary tract. Wiese CB, et al. Front Neurosci, 2012. PMID 22988430, Free PMC Article
    3. Mouse brain organization revealed through direct genome-scale TF expression analysis. Gray PA, et al. Science, 2004 Dec 24. PMID 15618518
    4. GUDMAP: the genitourinary developmental molecular anatomy project. McMahon AP, et al. J Am Soc Nephrol, 2008 Apr. PMID 18287559
    5. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    General gene information

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    Markers

    Homology

    Clone Names

    • 2810002D23Rik

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  

    General protein information

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    Preferred Names
    AN1-type zinc finger protein 4
    Names
    AN1, ubiquitin-like, homolog
    AN1-type zinc finger and ubiquitin domain-containing protein-like 1

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001290338.1 → NP_001277267.1  AN1-type zinc finger protein 4 isoform 1

      See identical proteins and their annotated locations for NP_001277267.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) differs in its 5' UTR, lacks a portion of the 5' coding region, and uses a downstream start codon, compared to variant 3. The encoded isoform (1) has a shorter N-terminus, compared to isoform 3.
      Source sequence(s)
      AA881170, AC147612, AK012639, BY619467, BY771310, CA465808
      Conserved Domains (1) summary
      smart00154
      Location:554 → 592
      ZnF_AN1; AN1-like Zinc finger

    2. NM_001290339.1 → NP_001277268.1  AN1-type zinc finger protein 4 isoform 2

      See identical proteins and their annotated locations for NP_001277268.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in its 5' UTR, lacks a portion of the 5' coding region, and uses a downstream start codon, compared to variant 3. The encoded isoform (2) has a shorter N-terminus, compared to isoform 3.
      Source sequence(s)
      AC147612, AK012639, BY619467, CX223310
      Conserved Domains (1) summary
      smart00154
      Location:452 → 490
      ZnF_AN1; AN1-like Zinc finger

    3. NM_001309446.1 → NP_001296375.1  AN1-type zinc finger protein 4 isoform 3

      See identical proteins and their annotated locations for NP_001296375.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) represents the longest transcript and encodes the longest isoform (3).
      Source sequence(s)
      AC123548, AC147612, AK012639, AV282255, BY771310
      Consensus CDS
      CCDS71818.2
      UniProtKB/Swiss-Prot
      D3Z3C6
      Related
      ENSMUSP00000040057.9, ENSMUST00000036503.14
      Conserved Domains (2) summary
      smart00154
      Location:679 → 717
      ZnF_AN1; AN1-like Zinc finger
      cd01802
      Location:54 → 127
      Ubl_ZFAND4; ubiquitin-like (Ubl) domain found in AN1-type zinc finger protein 4 (ZFAND4) and similar proteins

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      116241046..116310384
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006506506.5 → XP_006506569.1  AN1-type zinc finger protein 4 isoform X1

      See identical proteins and their annotated locations for XP_006506569.1

      UniProtKB/Swiss-Prot
      D3Z3C6
      Conserved Domains (2) summary
      smart00154
      Location:679 → 717
      ZnF_AN1; AN1-like Zinc finger
      cd01802
      Location:54 → 127
      Ubl_ZFAND4; ubiquitin-like (Ubl) domain found in AN1-type zinc finger protein 4 (ZFAND4) and similar proteins

    2. XM_006506510.5 → XP_006506573.1  AN1-type zinc finger protein 4 isoform X3

      Conserved Domains (2) summary
      smart00154
      Location:602 → 640
      ZnF_AN1; AN1-like Zinc finger
      cl28922
      Location:11 → 50
      Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold

    3. XM_030255564.2 → XP_030111424.1  AN1-type zinc finger protein 4 isoform X5

      Conserved Domains (1) summary
      smart00154
      Location:531 → 569
      ZnF_AN1; AN1-like Zinc finger

    4. XM_036152271.1 → XP_036008164.1  AN1-type zinc finger protein 4 isoform X4

      Conserved Domains (1) summary
      smart00154
      Location:554 → 592
      ZnF_AN1; AN1-like Zinc finger

    5. XM_006506515.4 → XP_006506578.1  AN1-type zinc finger protein 4 isoform X5

      See identical proteins and their annotated locations for XP_006506578.1

      Conserved Domains (1) summary
      smart00154
      Location:531 → 569
      ZnF_AN1; AN1-like Zinc finger

    6. XM_030255563.2 → XP_030111423.1  AN1-type zinc finger protein 4 isoform X5

      Conserved Domains (1) summary
      smart00154
      Location:531 → 569
      ZnF_AN1; AN1-like Zinc finger

    7. XM_011241443.4 → XP_011239745.1  AN1-type zinc finger protein 4 isoform X6

      Conserved Domains (1) summary
      smart00154
      Location:483 → 521
      ZnF_AN1; AN1-like Zinc finger

    8. XM_011241442.3 → XP_011239744.1  AN1-type zinc finger protein 4 isoform X5

      See identical proteins and their annotated locations for XP_011239744.1

      Conserved Domains (1) summary
      smart00154
      Location:531 → 569
      ZnF_AN1; AN1-like Zinc finger

    9. XM_006506508.5 → XP_006506571.1  AN1-type zinc finger protein 4 isoform X2

      Conserved Domains (2) summary
      smart00154
      Location:631 → 669
      ZnF_AN1; AN1-like Zinc finger
      cl28922
      Location:54 → 90
      Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold

    10. XM_011241444.4 → XP_011239746.1  AN1-type zinc finger protein 4 isoform X7

      See identical proteins and their annotated locations for XP_011239746.1

      Conserved Domains (1) summary
      smart00154
      Location:452 → 490
      ZnF_AN1; AN1-like Zinc finger

    11. XM_030255562.1 → XP_030111422.1  AN1-type zinc finger protein 4 isoform X4

      Conserved Domains (1) summary
      smart00154
      Location:554 → 592
      ZnF_AN1; AN1-like Zinc finger

    12. XM_006506507.5 → XP_006506570.1  AN1-type zinc finger protein 4 isoform X1

      See identical proteins and their annotated locations for XP_006506570.1

      UniProtKB/Swiss-Prot
      D3Z3C6
      Conserved Domains (2) summary
      smart00154
      Location:679 → 717
      ZnF_AN1; AN1-like Zinc finger
      cd01802
      Location:54 → 127
      Ubl_ZFAND4; ubiquitin-like (Ubl) domain found in AN1-type zinc finger protein 4 (ZFAND4) and similar proteins

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001081317.1: Suppressed sequence

      Description
      NM_001081317.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    D3Z3C6.2 GenPept UniProtKB/Swiss-Prot:D3Z3C6

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