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    B4galt2 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 2 [ Mus musculus (house mouse) ]

    Gene ID: 53418, updated on 27-Nov-2024

    Summary

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    Official Symbol
    B4galt2provided by MGI
    Official Full Name
    UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 2provided by MGI
    Primary source
    MGI:MGI:1858493
    See related
    Ensembl:ENSMUSG00000028541 AllianceGenome:MGI:1858493
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Ggtb2; b4Gal-T2; beta4Gal-T2
    Summary
    Predicted to enable galactosyltransferase activity. Acts upstream of or within cerebellar Purkinje cell layer development; learning or memory; and locomotory behavior. Predicted to be located in nucleoplasm. Predicted to be active in Golgi apparatus. Is expressed in early conceptus; eye; gonad; and nervous system. Orthologous to human B4GALT2 (beta-1,4-galactosyltransferase 2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in CNS E18 (RPKM 21.0), ovary adult (RPKM 20.1) and 23 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See B4galt2 in Genome Data Viewer
    Location:
    4 D1; 4 53.7 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (117730211..117740724, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (117873000..117883519, complement)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene peptidylprolyl isomerase A pseudogene 4_1138.1 Neighboring gene solute carrier family 6 (neurotransmitter transporter, glycine), member 9 Neighboring gene coiled-coil domain containing 24 Neighboring gene predicted gene, 40233 Neighboring gene predicted gene 12841 Neighboring gene ATPase, H+ transporting, lysosomal V0 subunit B Neighboring gene STARR-positive B cell enhancer ABC_E4652 Neighboring gene DPH2 homolog

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Learning/memory impairment and reduced expression of the HNK-1 carbohydrate in beta4-galactosyltransferase-II-deficient mice. Yoshihara T, et al. J Biol Chem, 2009 May 1. PMID 19265195, Free PMC Article
    2. Differential gene expression of beta-1,4-galactosyltransferases I, II and V during mouse brain development. Nakamura N, et al. J Neurochem, 2001 Jan. PMID 11145975
    3. The expanding beta 4-galactosyltransferase gene family: messages from the databanks. Lo NW, et al. Glycobiology, 1998 May. PMID 9597550
    4. Identification of novel oocyte and granulosa cell markers. Malcuit C, et al. Gene Expr Patterns, 2009 Sep. PMID 19539053
    5. Spatiotemporal Analysis of a Glycolytic Activity Gradient Linked to Mouse Embryo Mesoderm Development. Bulusu V, et al. Dev Cell, 2017 Feb 27. PMID 28245920, Free PMC Article

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (1)  1 citation

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables N-acetyllactosamine synthase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables galactosyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables lactose synthase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within brain development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in carbohydrate metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within cerebellar Purkinje cell layer development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in glycosylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within locomotory behavior IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within memory IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein glycosylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within visual learning IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in Golgi apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in Golgi cisterna membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    beta-1,4-galactosyltransferase 2
    Names
    N-acetyllactosamine synthase
    UDP-Gal:beta-GlcNAc beta-1,4-galactosyltransferase 2
    UDP-galactose:beta-N-acetylglucosamine beta-1,4-galactosyltransferase 2
    beta-1,4-GalTase 2
    beta-1,4-galactosyltransferase II
    beta-N-acetylglucosaminyl-glycolipid beta-1,4-galactosyltransferase
    beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase
    lactose synthase A protein
    nal synthase
    NP_001240310.1
    NP_001413067.1
    NP_059073.1
    XP_011238877.1
    XP_036020131.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001253381.2 → NP_001240310.1  beta-1,4-galactosyltransferase 2 isoform 1

      See identical proteins and their annotated locations for NP_001240310.1

      Status: VALIDATED

      Source sequence(s)
      AL627128
      Consensus CDS
      CCDS18539.1
      UniProtKB/Swiss-Prot
      Q3TMP2, Q9Z2Y2
      UniProtKB/TrEMBL
      B1ASJ2
      Related
      ENSMUSP00000102029.3, ENSMUST00000106421.9
      Conserved Domains (1) summary
      cd00899
      Location:142 → 358
      b4GalT; Beta-4-Galactosyltransferase is involved in the formation of the poly-N-acetyllactosamine core structures present in glycoproteins and glycosphingolipids

    2. NM_001426138.1 → NP_001413067.1  beta-1,4-galactosyltransferase 2 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL627128

    3. NM_017377.6 → NP_059073.1  beta-1,4-galactosyltransferase 2 isoform 1

      See identical proteins and their annotated locations for NP_059073.1

      Status: VALIDATED

      Source sequence(s)
      AL627128
      Consensus CDS
      CCDS18539.1
      UniProtKB/Swiss-Prot
      Q3TMP2, Q9Z2Y2
      UniProtKB/TrEMBL
      B1ASJ2
      Related
      ENSMUSP00000030266.6, ENSMUST00000030266.12
      Conserved Domains (1) summary
      cd00899
      Location:142 → 358
      b4GalT; Beta-4-Galactosyltransferase is involved in the formation of the poly-N-acetyllactosamine core structures present in glycoproteins and glycosphingolipids

    RNA

    1. NR_045570.2 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL627128
      Related
      ENSMUST00000167443.8

    2. NR_189666.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL627128

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      117730211..117740724 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036164238.1 → XP_036020131.1  beta-1,4-galactosyltransferase 2 isoform X2

      Conserved Domains (1) summary
      cd00899
      Location:142 → 320
      b4GalT; Beta-4-Galactosyltransferase is involved in the formation of the poly-N-acetyllactosamine core structures present in glycoproteins and glycosphingolipids

    2. XM_011240575.4 → XP_011238877.1  beta-1,4-galactosyltransferase 2 isoform X1

      Conserved Domains (1) summary
      cl11394
      Location:142 → 317
      Glyco_tranf_GTA_type; Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold

    RNA

    1. XR_867887.3 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9Z2Y2.1 GenPept UniProtKB/Swiss-Prot:Q9Z2Y2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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