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    Cdk6 cyclin dependent kinase 6 [ Mus musculus (house mouse) ]

    Gene ID: 12571, updated on 9-Dec-2024

    Summary

    Official Symbol
    Cdk6provided by MGI
    Official Full Name
    cyclin dependent kinase 6provided by MGI
    Primary source
    MGI:MGI:1277162
    See related
    Ensembl:ENSMUSG00000040274 AllianceGenome:MGI:1277162
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Crk2
    Summary
    This gene encodes a member of the cyclin dependent kinase family of proteins that play important roles in the progression and regulation of the cell cycle. The encoded protein binds to a D-type cyclin to form an active kinase complex to regulate progression through the G1 phase of the cell cycle. Mice lacking the encoded protein exhibit thymic and splenic hypoplasia, and hematopoietic defects such as reduced number of megakaryocytes and erythrocytes. A pseudogene of this gene has been defined on chromosome 4. [provided by RefSeq, Aug 2015]
    Expression
    Ubiquitous expression in thymus adult (RPKM 7.0), lung adult (RPKM 3.6) and 26 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Cdk6 in Genome Data Viewer
    Location:
    5 A1; 5 2.04 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (3391004..3581008)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (3341004..3531008)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_12300 Neighboring gene ribosomal protein L26 pseudogene Neighboring gene STARR-seq mESC enhancer starr_12301 Neighboring gene STARR-seq mESC enhancer starr_12302 Neighboring gene predicted gene, 36548 Neighboring gene STARR-seq mESC enhancer starr_12303 Neighboring gene STARR-seq mESC enhancer starr_12305 Neighboring gene cyclin dependent kinase 6, opposite strand transcript 1 Neighboring gene STARR-seq mESC enhancer starr_12306 Neighboring gene STARR-seq mESC enhancer starr_12307 Neighboring gene STARR-positive B cell enhancer ABC_E10299 Neighboring gene STARR-positive B cell enhancer ABC_E2150 Neighboring gene STARR-positive B cell enhancer ABC_E2736 Neighboring gene STARR-seq mESC enhancer starr_12309 Neighboring gene predicted gene, 29868 Neighboring gene STARR-seq mESC enhancer starr_12311 Neighboring gene STARR-positive B cell enhancer ABC_E4741 Neighboring gene RIKEN cDNA 1700109H08 gene Neighboring gene STARR-seq mESC enhancer starr_12313 Neighboring gene family with sequence similarity 133, member B Neighboring gene STARR-seq mESC enhancer starr_12314 Neighboring gene RNA binding motif protein 48

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Gene trapped (1) 
    • Targeted (12)  1 citation

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables ATP binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables FBXO family protein binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables FBXO family protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables cyclin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables cyclin binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables cyclin binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables cyclin-dependent protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables cyclin-dependent protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables cyclin-dependent protein serine/threonine kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in DNA damage response IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in DNA damage response ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in G1/S transition of mitotic cell cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in G1/S transition of mitotic cell cycle IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in G1/S transition of mitotic cell cycle ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within Notch signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within Notch signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within T cell differentiation in thymus IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cell dedifferentiation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cell dedifferentiation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cell division IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within cell quiescence IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in gliogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in gliogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within hematopoietic progenitor cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within hematopoietic stem cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in hemopoiesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of cell cycle IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of cell cycle ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of cellular senescence IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of cellular senescence ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of epithelial cell proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of epithelial cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of monocyte differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of monocyte differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of myeloid cell differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of osteoblast differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of osteoblast differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of cell-matrix adhesion IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of cell-matrix adhesion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of fibroblast proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of fibroblast proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within positive regulation of gene expression IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of G2/M transition of mitotic cell cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in regulation of erythrocyte differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of erythrocyte differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of gene expression IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within regulation of hematopoietic stem cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within response to 5-fluorouracil IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in response to virus IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in type B pancreatic cell development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in type B pancreatic cell development ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in centrosome ISO
    Inferred from Sequence Orthology
    more info
     
    located_in centrosome ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    part_of cyclin D1-CDK6 complex IEA
    Inferred from Electronic Annotation
    more info
     
    part_of cyclin D1-CDK6 complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of cyclin D2-CDK6 complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of cyclin D3-CDK6 complex IEA
    Inferred from Electronic Annotation
    more info
     
    part_of cyclin D3-CDK6 complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of cyclin-dependent protein kinase holoenzyme complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of cyclin-dependent protein kinase holoenzyme complex ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in ruffle IEA
    Inferred from Electronic Annotation
    more info
     
    located_in ruffle ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    cyclin-dependent kinase 6
    Names
    CR2 protein kinase
    cell division protein kinase 6
    serine/threonine-protein kinase PLSTIRE
    NP_034003.1
    XP_030109951.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_009873.3NP_034003.1  cyclin-dependent kinase 6

      See identical proteins and their annotated locations for NP_034003.1

      Status: REVIEWED

      Source sequence(s)
      AC026478, AC090443, AK078973, BQ176468
      Consensus CDS
      CCDS19062.1
      UniProtKB/Swiss-Prot
      Q64261, Q9R1D2, Q9R1D3
      UniProtKB/TrEMBL
      Q0VBK8, Q3U4J9
      Related
      ENSMUSP00000126024.2, ENSMUST00000165117.8
      Conserved Domains (1) summary
      cd07862
      Location:11300
      STKc_CDK6; Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 6

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      3391004..3581008
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030254091.1XP_030109951.1  cyclin-dependent kinase 6 isoform X1

      UniProtKB/Swiss-Prot
      Q64261, Q9R1D2, Q9R1D3
      UniProtKB/TrEMBL
      Q0VBK8, Q3U4J9
      Conserved Domains (1) summary
      cd07862
      Location:11300
      STKc_CDK6; Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 6