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    LAF1 Laf1p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 855128, updated on 9-Dec-2024

    Summary

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    Official Symbol
    LAF1
    Official Full Name
    Laf1p
    Primary source
    SGD:S000004708
    Locus tag
    YMR102C
    See related
    AllianceGenome:SGD:S000004708; FungiDB:YMR102C; VEuPathDB:YMR102C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Acts upstream of or within sterol transport. Orthologous to human WDR44 (WD repeat domain 44). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See LAF1 in Genome Data Viewer
    Location:
    chromosome: XIII
    Exon count:
    1
    Sequence:
    Chromosome: XIII; NC_001145.3 (469848..472352, complement)

    Chromosome XIII - NC_001145.3Genomic Context describing neighboring genes Neighboring gene Mub1p Neighboring gene ditrans,polycis-polyprenyl diphosphate synthase Neighboring gene uncharacterized protein Neighboring gene putative protein kinase YPK2

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001145.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Mode of selection and experimental evolution of antifungal drug resistance in Saccharomyces cerevisiae. Anderson JB, et al. Genetics, 2003 Apr. PMID 12702675, Free PMC Article
    2. TORC2-Dependent Ypk1-Mediated Phosphorylation of Lam2/Ltc4 Disrupts Its Association with the β-Propeller Protein Laf1 at Endoplasmic Reticulum-Plasma Membrane Contact Sites in the Yeast Saccharomyces cerevisiae. Topolska M, et al. Biomolecules, 2020 Nov 25. PMID 33255682, Free PMC Article
    3. Sterol transporters at membrane contact sites regulate TORC1 and TORC2 signaling. Murley A, et al. J Cell Biol, 2017 Sep 4. PMID 28774891, Free PMC Article
    4. Competitive promoter occupancy by two yeast paralogous transcription factors controlling the multidrug resistance phenomenon. Lucau-Danila A, et al. J Biol Chem, 2003 Dec 26. PMID 14512416
    5. Tolerance to nascent protein misfolding stress requires fine-tuning of the cAMP/PKA pathway. Kritsiligkou P, et al. J Biol Chem, 2021 Jan-Jun. PMID 33894203, Free PMC Article

    See all (40) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. TORC2-Dependent Ypk1-Mediated Phosphorylation of Lam2/Ltc4 Disrupts Its Association with the beta-Propeller Protein Laf1 at Endoplasmic Reticulum-Plasma Membrane Contact Sites in the Yeast Saccharomyces cerevisiae.
      Title: TORC2-Dependent Ypk1-Mediated Phosphorylation of Lam2/Ltc4 Disrupts Its Association with the β-Propeller Protein Laf1 at Endoplasmic Reticulum-Plasma Membrane Contact Sites in the Yeast Saccharomyces cerevisiae.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within sterol transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  

    General protein information

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    Preferred Names
    Laf1p
    NP_013820.1
    • Sterol-binding beta-propeller protein; physically associates with sterol-binding StARkin domain-containing proteins Ysp2/Lam2/Ltc4 and Lam4/Ltc3; essential for retrograde transport of ergosterol from the plasma membrane to the endoplasmic reticulum at ER-PM contact sites; transcription is activated by paralogous transcription factors Yrm1p and Yrr1p along with genes involved in multidrug resistance; non-essential gene; has a paralog, DGR2, that arose from the whole genome duplication

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001145.3 Reference assembly

      Range
      469848..472352 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001182602.1 → NP_013820.1  TPA: Laf1p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_013820.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VZS5, Q03138, Q03177, Q04435
      UniProtKB/TrEMBL
      A6ZMF9, B3LLZ3, B5VPN0, G2WKF0, N1NYC8
      Conserved Domains (2) summary
      sd00039
      Location:176 → 221
      7WD40; WD40 repeat [structural motif]
      cl29593
      Location:173 → 506
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q03177.1

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