frmA S-(hydroxymethyl)glutathione dehydrogenase [Escherichia coli str. K-12 substr. MG1655] - Gene

Summary

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Official Symbol: frmA
Official Full Name: S-(hydroxymethyl)glutathione dehydrogenase
Primary source: ECOCYC:EG50010
Locus tag: b0356
See related: ASAP:ABE-0001221
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage: Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as: adhC; ECK0353
Summary: The frmRAB operon is negatively regulated by frmR, is induced by formaldehyde, and probably degrades formaldehyde. [More information is available at EcoGene: EG50010]. Glutathione-dependent formaldehyde dehydrogenase (GS-FDH) belongs to the family of class III alcohol dehydrogenases. [More information is available at EcoCyc: EG50010].
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Genomic context

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Sequence:: NC_000913.3 (378462..379571, complement)

NC_000913.3 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

N-terminus verified by Edman degradation on complete protein
Title: Purification, characterization, and partial sequence of the glutathione-dependent formaldehyde dehydrogenase from Escherichia coli: a class III alcohol dehydrogenase.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by EcoCyc

Function	Evidence Code	Pubs
enables S-(hydroxymethyl)glutathione dehydrogenase (NAD+) activity	IEA Inferred from Electronic Annotation more info
enables S-(hydroxymethyl)glutathione dehydrogenase (NADP+) activity	IEA Inferred from Electronic Annotation more info
enables S-(hydroxymethyl)glutathione dehydrogenase [NAD(P)+] activity	IBA Inferred from Biological aspect of Ancestor more info
enables S-(hydroxymethyl)glutathione dehydrogenase [NAD(P)+] activity	IDA Inferred from Direct Assay more info	PubMed
enables S-(hydroxymethyl)glutathione dehydrogenase [NAD(P)+] activity	IEA Inferred from Electronic Annotation more info
enables S-nitrosoglutathione reductase (NADH) activity	IEA Inferred from Electronic Annotation more info
enables alcohol dehydrogenase (NAD+) activity	IBA Inferred from Biological aspect of Ancestor more info
enables alcohol dehydrogenase (NAD+) activity	IEA Inferred from Electronic Annotation more info
enables identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	IEA Inferred from Electronic Annotation more info
enables zinc ion binding	IBA Inferred from Biological aspect of Ancestor more info
enables zinc ion binding	IDA Inferred from Direct Assay more info	PubMed
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in formaldehyde catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in formaldehyde catabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within formaldehyde catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in small molecule metabolic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytosol	HDA more info	PubMed
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: S-(hydroxymethyl)glutathione dehydrogenase

NP_414890.1

EC 1.1.1.284

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_000913.3 Reference assembly

Range

378462..379571 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NP_414890.1 S-(hydroxymethyl)glutathione dehydrogenase [Escherichia coli str. K-12 substr. MG1655]

See identical proteins and their annotated locations for NP_414890.1

Status: PROVISIONAL

UniProtKB/TrEMBL

A0A2X1MVC5, A0A5B9AWG4, A0A8H9SJQ1

Conserved Domains (1) summary

cd08300
Location:1 → 368

alcohol_DH_class_III; class III alcohol dehydrogenases