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    fimA type 1 fimbriae major subunit [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 948838, updated on 3-Dec-2024

    Summary

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    Official Symbol
    fimA
    Official Full Name
    type 1 fimbriae major subunit
    Primary source
    ECOCYC:EG10308
    Locus tag
    b4314
    See related
    ASAP:ABE-0014145
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK4305; fimD; pilA
    Summary
    One of 25 FimA homologs in EcoGene. [More information is available at EcoGene: EG10308]. FimA, the major subunit of the Escherichia coli type 1 fimbriae (pili) has been identified and its gene sequence determined , . [More information is available at EcoCyc: EG10308].
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    Genomic context

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    Sequence:
    NC_000913.3 (4543115..4543663)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene Type 1 fimbriae regulatory protein FimB Neighboring gene regulator for fimA Neighboring gene putative fimbrial protein FimI Neighboring gene type 1 fimbriae periplasmic chaperone

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Structure, folding and stability of FimA, the main structural subunit of type 1 pili from uropathogenic Escherichia coli strains. Puorger C, et al. J Mol Biol, 2011 Sep 23. PMID 21816158
    2. Identification and characterization of a gene product that regulates type 1 piliation in Escherichia coli. Orndorff PE, et al. J Bacteriol, 1984 Oct. PMID 6148338, Free PMC Article
    3. Role of type 1 fimbriae and mannose in the development of Escherichia coli K12 biofilm: from initial cell adhesion to biofilm formation. Rodrigues DF, et al. Biofouling, 2009. PMID 19306144
    4. Glycerol-induced unraveling of the tight helical conformation of Escherichia coli type 1 fimbriae. Abraham SN, et al. J Bacteriol, 1992 Aug. PMID 1352770, Free PMC Article
    5. F7 and type 1-like fimbriae from three Escherichia coli strains isolated from urinary tract infections: protein chemical and immunological aspects. Klemm P, et al. Infect Immun, 1982 May. PMID 6123483, Free PMC Article

    See all (57) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Donor strand sequence, rather than donor strand orientation, determines the stability and non-equilibrium folding of the type 1 pilus subunit FimA.
      Title: Donor strand sequence, rather than donor strand orientation, determines the stability and non-equilibrium folding of the type 1 pilus subunit FimA.
    2. X-ray structures of all three FimA monomers at 0.89-1.69 A resolutions, reveal identical, intramolecular donor-strand complementation mechanisms. Our results also showed that the pseudo-palindromic sequences of the donor strands in all FimA proteins permit their alternative folding possibilities.
      Title: Alternative folding to a monomer or homopolymer is a common feature of the type 1 pilus subunit FimA from enteroinvasive bacteria.
    3. FimA is capable of intramolecular self-complementation via its own donor strand, as evidenced by the loss of folding competence upon donor strand deletion.
      Title: Structure, folding and stability of FimA, the main structural subunit of type 1 pili from uropathogenic Escherichia coli strains.
    4. Results show that pilA recombinant protein has some immunoprotection effect with the challenging of virulent strains of E. coli GH1.2.
      Title: [Prokaryotic expression of pilA gene of type I pilus of enteropathogenic Escherichia coli isolated from ducks and the immunoprotection effect of recombinant expression protein challenged with virulent strains].
    5. report the identification of a soluble form of the pilus protein FimA from the culture supernatants of E. coli K1, Salmonella, and Shigella that can potently inhibit Bax-mediated release of cytochrome c from isolated mitochondria.
      Title: A soluble form of the pilus protein FimA targets the VDAC-hexokinase complex at mitochondria to suppress host cell apoptosis.
    6. N-terminus verified by Edman degradation on mature peptide
      Title: F7 and type 1-like fimbriae from three Escherichia coli strains isolated from urinary tract infections: protein chemical and immunological aspects.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within cell adhesion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in cell adhesion IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cell adhesion involved in single-species biofilm formation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in pilus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in pilus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in pilus RCA
    inferred from Reviewed Computational Analysis
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    type 1 fimbriae major subunit

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      4543115..4543663
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_418734.1 type 1 fimbriae major subunit [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_418734.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      Q4VU76
      Conserved Domains (1) summary
      cl01416
      Location:28 → 182
      Fimbrial; Fimbrial protein
    Nucleotide Protein
    Heading Accession and Version

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