U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    hisC histidinol-phosphate aminotransferase [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 946551, updated on 3-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    hisC
    Official Full Name
    histidinol-phosphate aminotransferase
    Primary source
    ECOCYC:EG10446
    Locus tag
    b2021
    See related
    ASAP:ABE-0006717
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK2016
    Summary
    Histidinol-phosphate aminotransferase (HisC) catalyzes the seventh step in the biosynthesis of histidine. [More information is available at EcoCyc: EG10446].
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    Sequence:
    NC_000913.3 (2092398..2093468)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene his operon leader peptide Neighboring gene ATP phosphoribosyltransferase Neighboring gene histidinal/histidinol dehydrogenase Neighboring gene imidazoleglycerol-phosphate dehydratase/histidinol-phosphatase Neighboring gene imidazole glycerol phosphate synthase subunit HisH Neighboring gene 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino]imidazole-4-carboxamide isomerase Neighboring gene imidazole glycerol phosphate synthase subunit HisF

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Cloning, structure, and expression of the Escherichia coli K-12 hisC gene. Grisolia V, et al. J Bacteriol, 1985 Dec. PMID 2999081, Free PMC Article
    2. Imidazolylacetolphosphate:L-glutamate aminotransferase. Purification and physical properties. Martin RG, et al. J Biol Chem, 1967 Mar 25. PMID 5337155
    3. Characterization of histidinol phosphate aminotransferase from Escherichia coli. Mizuguchi H, et al. Biochim Biophys Acta, 2003 Apr 11. PMID 12686152
    4. Structures of Escherichia coli histidinol-phosphate aminotransferase and its complexes with histidinol-phosphate and N-(5'-phosphopyridoxyl)-L-glutamate: double substrate recognition of the enzyme. Haruyama K, et al. Biochemistry, 2001 Apr 17. PMID 11294630
    5. Crystal structure of histidinol phosphate aminotransferase (HisC) from Escherichia coli, and its covalent complex with pyridoxal-5'-phosphate and l-histidinol phosphate. Sivaraman J, et al. J Mol Biol, 2001 Aug 24. PMID 11518529

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

    Go to the top of the page

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables histidinol-phosphate transaminase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables histidinol-phosphate transaminase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables identical protein binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables pyridoxal phosphate binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transaminase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in L-histidine biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within L-histidine biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

    Go to the top of the page Help
    Preferred Names
    histidinol-phosphate aminotransferase
    NP_416525.1

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      2092398..2093468
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_416525.1 histidinol-phosphate aminotransferase [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_416525.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A8I0CCU9
      Conserved Domains (1) summary
      PRK01688
      Location:3 → 352
      PRK01688; histidinol-phosphate aminotransferase; Provisional
    Nucleotide Protein
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.