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    waaQ lipopolysaccharide core heptosyltransferase 3 [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 948155, updated on 3-Dec-2024

    Summary

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    Official Symbol
    waaQ
    Official Full Name
    lipopolysaccharide core heptosyltransferase 3
    Primary source
    ECOCYC:EG11341
    Locus tag
    b3632
    See related
    ASAP:ABE-0011870
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK3622; rfaQ
    Summary
    The lipopolysaccharide of Escherichia coli K-12 consists of two major components: the hydrophobic lipid A moiety inserted into the outer membrane and the phosphorylated core oligosaccharide . [More information is available at EcoCyc: EG11341].
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    Genomic context

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    Sequence:
    NC_000913.3 (3807064..3808098, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene lipopolysaccharide core biosynthesis protein WaaS Neighboring gene lipopolysaccharide core heptose (I) kinase Neighboring gene lipopolysaccharide glucosyltransferase I Neighboring gene ncRNA Neighboring gene KDO transferase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Glycosyltransferase functions of E. coli O-antigens. Lundborg M, et al. Glycobiology, 2010 Mar. PMID 19926726
    2. The presence of OMP inclusion bodies in a Escherichia coli K-12 mutated strain is not related to lipopolysaccharide structure. Corsaro MM, et al. J Biochem, 2009 Aug. PMID 19364804
    3. Cloning and characterization of the Escherichia coli Heptosyltransferase III: Exploring substrate specificity in lipopolysaccharide core biosynthesis. Mudapaka J, et al. FEBS Lett, 2015 Jun 4. PMID 25957775
    4. An Escherichia coli MG1655 lipopolysaccharide deep-rough core mutant grows and survives in mouse cecal mucus but fails to colonize the mouse large intestine. Møller AK, et al. Infect Immun, 2003 Apr. PMID 12654836, Free PMC Article
    5. Genes for TDP-rhamnose synthesis affect the pattern of lipopolysaccharide heterogeneity in Escherichia coli K-12. Klena JD, et al. J Bacteriol, 1994 Jul. PMID 7517388, Free PMC Article

    See all (30) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Data indicate that Heptosyltransferase III (HepIII; WaaQ protein) catalyzes the addition of an L-glycero-D-manno-heptose (Hep) residue to the growing lipopolysaccharide (LPS) core via an alpha(1-->7) bond.
      Title: Cloning and characterization of the Escherichia coli Heptosyltransferase III: Exploring substrate specificity in lipopolysaccharide core biosynthesis.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables ADP-heptose-lipopolysaccharide heptosyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables glycosyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables lipopolysaccharide core heptosyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in lipopolysaccharide biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in lipopolysaccharide core region biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in lipopolysaccharide core region biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within lipopolysaccharide core region biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    lipopolysaccharide core heptosyltransferase 3

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      3807064..3808098 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_418089.1 lipopolysaccharide core heptosyltransferase 3 [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_418089.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      O68210
      Conserved Domains (1) summary
      PRK10422
      Location:1 → 340
      PRK10422; lipopolysaccharide core biosynthesis protein; Provisional
    Nucleotide Protein
    Heading Accession and Version

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