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    bdcA c-di-GMP-binding biofilm dispersal mediator protein [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 948765, updated on 17-Dec-2024

    Summary

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    Official Symbol
    bdcA
    Official Full Name
    c-di-GMP-binding biofilm dispersal mediator protein
    Primary source
    ECOCYC:G7880
    Locus tag
    b4249
    See related
    ASAP:ABE-0013909
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK4243; yjgI
    Summary
    The divergent YjgJ could be be a YjgI regulator. [More information is available at EcoGene: EG12528]. YjgI did not show dehydrogenase activity in a high-throughput screen of purified proteins . [More information is available at EcoCyc: G7880].
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    Genomic context

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    Sequence:
    NC_000913.3 (4473340..4474053, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene pyrBI operon leader peptide Neighboring gene RutC family protein YjgH Neighboring gene putative transcriptional regulator BdcR Neighboring gene DUF386 domain-containing toxin-antitoxin biofilm protein TabA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A potential substrate binding pocket of BdcA plays a critical role in NADPH recognition and biofilm dispersal. Yang WS, et al. Biochem Biophys Res Commun, 2018 Mar 11. PMID 29462616
    2. BdcA, a protein important for Escherichia coli biofilm dispersal, is a short-chain dehydrogenase/reductase that binds specifically to NADPH. Lord DM, et al. PLoS One, 2014. PMID 25244619, Free PMC Article
    3. Engineering a novel c-di-GMP-binding protein for biofilm dispersal. Ma Q, et al. Environ Microbiol, 2011 Mar. PMID 21059164, Free PMC Article
    4. Analysis of the Escherichia coli genome VI: DNA sequence of the region from 92.8 through 100 minutes. Burland V, et al. Nucleic Acids Res, 1995 Jun 25. PMID 7610040, Free PMC Article
    5. Enzyme genomics: Application of general enzymatic screens to discover new enzymes. Kuznetsova E, et al. FEMS Microbiol Rev, 2005 Apr. PMID 15808744

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables NADPH binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables cyclic-di-GMP binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein homodimerization activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within single-species biofilm formation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    c-di-GMP-binding biofilm dispersal mediator protein

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      4473340..4474053 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_418670.1 c-di-GMP-binding biofilm dispersal mediator protein [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_418670.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A0J9X1Z4
      Conserved Domains (1) summary
      PRK12742
      Location:1 → 237
      PRK12742; SDR family oxidoreductase
    Nucleotide Protein
    Heading Accession and Version

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