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    TMSB15B thymosin beta 15B [ Homo sapiens (human) ]

    Gene ID: 286527, updated on 10-Dec-2024

    Summary

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    Official Symbol
    TMSB15Bprovided by HGNC
    Official Full Name
    thymosin beta 15Bprovided by HGNC
    Primary source
    HGNC:HGNC:28612
    See related
    Ensembl:ENSG00000158427 MIM:301011; AllianceGenome:HGNC:28612
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    TMSL8; TMSNB; TMSB15A; Tbeta15b
    Summary
    Predicted to enable actin monomer binding activity. Involved in positive regulation of cell migration. Predicted to be located in cytoskeleton. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in ovary (RPKM 5.0), endometrium (RPKM 4.8) and 22 other tissues See more
    Orthologs
    all
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    Genomic context

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    See TMSB15B in Genome Data Viewer
    Location:
    Xq22.2
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) X NC_000023.11 (103919155..103974426)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) X NC_060947.1 (102360190..102415483)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (103173738..103229008)

    Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene TMSB15B antisense RNA 1 Neighboring gene H2B histone pseudogene 9 Neighboring gene ELF2 pseudogene 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29824 Neighboring gene SLC25A53 pseudogene 1 Neighboring gene DPPA3 pseudogene 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chrX:103238205-103238704 Neighboring gene uncharacterized LOC107987334 Neighboring gene H2B.W histone 4, pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Thymosin beta-NB is the human isoform of rat thymosin beta15. Banyard J, et al. Ann N Y Acad Sci, 2007 Sep. PMID 17567946
    2. Differential regulation of human thymosin beta 15 isoforms by transforming growth factor beta 1. Banyard J, et al. Genes Chromosomes Cancer, 2009 Jun. PMID 19296525, Free PMC Article
    3. Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. Gevaert K, et al. Nat Biotechnol, 2003 May. PMID 12665801
    4. The DNA sequence of the human X chromosome. Ross MT, et al. Nature, 2005 Mar 17. PMID 15772651, Free PMC Article
    5. SUMOylation of DDX39A Alters Binding and Export of Antiviral Transcripts to Control Innate Immunity. Shi P, et al. J Immunol, 2020 Jul 1. PMID 32393512

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Potential readthrough

    Included gene: H2BW4P

    Homology

    Clone Names

    • MGC39900

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables actin monomer binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in actin filament organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of cell migration IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of cell migration IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in sequestering of actin monomers IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    thymosin beta-15B
    Names
    NB thymosin beta
    Thymosin beta-15A
    Thymosin-like protein 8

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001350211.2 → NP_001337140.1  thymosin beta-15B isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) represents use of an alternate promoter and contains a longer 5' UTR compared to variant 1.
      Source sequence(s)
      BC019900
      Consensus CDS
      CCDS59172.1
      UniProtKB/Swiss-Prot
      A8K614, P0CG34, P0CG35, P0DX04, Q99406
      Related
      ENSP00000456121.1, ENST00000419165.5
      Conserved Domains (1) summary
      pfam01290
      Location:3 → 39
      Thymosin; Thymosin beta-4 family

    2. NM_001350212.2 → NP_001337141.1  thymosin beta-15B isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) contains an alternate exon in the 5' UTR compared to variant 1.
      Source sequence(s)
      AC234782, BQ011701, CN271772
      Consensus CDS
      CCDS59172.1
      UniProtKB/Swiss-Prot
      A8K614, P0CG34, P0CG35, P0DX04, Q99406
      Related
      ENSP00000457057.1, ENST00000569577.1
      Conserved Domains (1) summary
      pfam01290
      Location:3 → 39
      Thymosin; Thymosin beta-4 family

    3. NM_001350213.2 → NP_001337142.1  thymosin beta-15B isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) represents use of an alternate promoter and differs in both the 5' and 3' exon structure compared to variant 1. The encoded isoform (2) has a longer, distinct C-terminus compared to isoform 1.
      Source sequence(s)
      AC234782
      UniProtKB/TrEMBL
      A0A087X1C1
      Conserved Domains (1) summary
      pfam01290
      Location:3 → 33
      Thymosin; Thymosin beta-4 family

    4. NM_194324.4 → NP_919305.2  thymosin beta-15B isoform 1

      See identical proteins and their annotated locations for NP_919305.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the canonical isoform (1).
      Source sequence(s)
      BC093093, BQ011701
      Consensus CDS
      CCDS59172.1
      UniProtKB/Swiss-Prot
      A8K614, P0CG34, P0CG35, P0DX04, Q99406
      Related
      ENSP00000455371.1, ENST00000540220.6
      Conserved Domains (1) summary
      pfam01290
      Location:3 → 39
      Thymosin; Thymosin beta-4 family

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000023.11 Reference GRCh38.p14 Primary Assembly

      Range
      103919155..103974426
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060947.1 Alternate T2T-CHM13v2.0

      Range
      102360190..102415483
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P0CG35.1 GenPept UniProtKB/Swiss-Prot:P0CG35

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials