Polr3h polymerase (RNA) III (DNA directed) polypeptide H [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Polr3hprovided by MGI
Official Full Name: polymerase (RNA) III (DNA directed) polypeptide Hprovided by MGI
Primary source: MGI:MGI:1926179
See related: Ensembl:ENSMUSG00000022476 AllianceGenome:MGI:1926179
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: RPC8; 5031409G22Rik
Summary: Predicted to enable DNA-directed 5'-3' RNA polymerase activity. Predicted to be involved in transcription initiation at RNA polymerase III promoter. Predicted to be located in centrosome and nucleoplasm. Predicted to be part of RNA polymerase III complex. Is expressed in several structures, including alimentary system; limb; nervous system; respiratory system; and sensory organ. Used to study primary ovarian insufficiency. Orthologous to human POLR3H (RNA polymerase III subunit H). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Ubiquitous expression in spleen adult (RPKM 15.6), cortex adult (RPKM 10.0) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 15 E1; 15 38.26 cM

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	15	NC_000081.7 (81799231..81813824, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	15	NC_000081.6 (81915030..81926247, complement)

Chromosome 15 - NC_000081.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Loss-of-function Polr3h mutation in mice caused early embryonic lethality. Mice with homozygous point mutation (Polr3hD50G) were viable but showed delayed pubertal development, characterized by late first estrus or preputial separation. The Polr3hD50G female and male mice showed decreased fertility later in life, associated with small litter size and increased time to pregnancy or to impregnate a female.
Title: Exome Sequencing Reveals the POLR3H Gene as a Novel Cause of Primary Ovarian Insufficiency.
Pol III regulation in the liver thus entails both highly expressed housekeeping genes and genes whose expression can adapt to increased demand.
Title: Differential regulation of RNA polymerase III genes during liver regeneration.
Pol III transcription during the diurnal cycle is regulated both in response to nutrients and by the circadian clock, which allows anticipatory Pol III transcription.
Title: Diurnal regulation of RNA polymerase III transcription is under the control of both the feeding-fasting response and the circadian clock.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (5) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

NoName (e-PCR)
- UniSTS:237361

Polr3h (e-PCR), detects polymorphism
- UniSTS:547291

D15Mit118 (e-PCR), detects polymorphism
- UniSTS:127478

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA-directed 5'-3' RNA polymerase activity	ISO Inferred from Sequence Orthology more info
enables DNA-directed 5'-3' RNA polymerase activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in DNA-templated transcription initiation	IEA Inferred from Electronic Annotation more info
involved_in defense response to virus	IEA Inferred from Electronic Annotation more info
involved_in innate immune response	IEA Inferred from Electronic Annotation more info
involved_in nucleobase-containing compound metabolic process	ISO Inferred from Sequence Orthology more info
involved_in nucleobase-containing compound metabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in transcription by RNA polymerase III	ISO Inferred from Sequence Orthology more info
involved_in transcription by RNA polymerase III	ISS Inferred from Sequence or Structural Similarity more info
involved_in transcription initiation at RNA polymerase III promoter	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
part_of RNA polymerase III complex	IBA Inferred from Biological aspect of Ancestor more info
part_of RNA polymerase III complex	ISO Inferred from Sequence Orthology more info
part_of RNA polymerase III complex	ISS Inferred from Sequence or Structural Similarity more info
located_in centrosome	IEA Inferred from Electronic Annotation more info
located_in centrosome	ISO Inferred from Sequence Orthology more info
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: DNA-directed RNA polymerase III subunit RPC8

Names: DNA-directed RNA polymerase III subunit H; RNA polymerase III subunit C7

NP_084505.2

EC 2.7.7.6

XP_006521608.1

EC 2.7.7.6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_030229.4 → NP_084505.2 DNA-directed RNA polymerase III subunit RPC8

See identical proteins and their annotated locations for NP_084505.2

Status: PROVISIONAL

Source sequence(s)

AC102103

Consensus CDS

CCDS27676.1

UniProtKB/Swiss-Prot

Q91XE5, Q9D2C6

UniProtKB/TrEMBL

Q3U7U0

Related

ENSMUSP00000023113.6, ENSMUST00000023113.7

Conserved Domains (2) summary

cd04330
Location:2 → 81

RNAP_III_Rpc25_N; Rpc25, N-terminal ribonucleoprotein (RNP) domain. Rpc25 is a subunit of eukaryotic RNA polymerase (RNAP) III and is homologous to Rpa43 of eukaryotic RNAP I, Rpb7 of eukaryotic RNAP II, and RpoE of archaeal RNAP. Rpc25 has two domains, an N-terminal RNP ...

pfam08292
Location:83 → 201

RNA_pol_Rbc25; RNA polymerase III subunit Rpc25

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000081.7 Reference GRCm39 C57BL/6J

Range

81799231..81813824 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006521545.4 → XP_006521608.1 DNA-directed RNA polymerase III subunit RPC8 isoform X1

Conserved Domains (2) summary

cd04330
Location:2 → 81

RNAP_III_Rpc25_N; Rpc25, N-terminal ribonucleoprotein (RNP) domain. Rpc25 is a subunit of eukaryotic RNA polymerase (RNAP) III and is homologous to Rpa43 of eukaryotic RNAP I, Rpb7 of eukaryotic RNAP II, and RpoE of archaeal RNAP. Rpc25 has two domains, an N-terminal RNP ...

cl09927
Location:79 → 119

S1_like; Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain. Both domains ...