ERR3 phosphopyruvate hydratase ERR3 [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: ERR3
Official Full Name: phosphopyruvate hydratase ERR3
Primary source: SGD:S000004942
Locus tag: YMR323W
See related: AllianceGenome:SGD:S000004942; FungiDB:YMR323W; VEuPathDB:YMR323W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Enables phosphopyruvate hydratase activity. Predicted to be involved in glycolytic process. Located in cytoplasm. Human ortholog(s) of this gene implicated in Alzheimer's disease. Orthologous to human ENO1 (enolase 1) and ENO3 (enolase 3). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See ERR3 in Genome Data Viewer

Location:: chromosome: XIII

Exon count:: 1

Sequence:: Chromosome: XIII; NC_001145.3 (920088..921401)

Chromosome XIII - NC_001145.3 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001145.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

In addition, Err2p and Err3p can convert 2-phosphoglycerate to phosphoenolpyruvate, with kinetic parameters similar to those of Eno1p, suggesting that these proteins could function as enolases in vivo.
Title: The Saccharomyces cerevisiae enolase-related regions encode proteins that are active enolases.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables lyase activity	IEA Inferred from Electronic Annotation more info
enables magnesium ion binding	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables phosphopyruvate hydratase activity	IBA Inferred from Biological aspect of Ancestor more info
enables phosphopyruvate hydratase activity	IDA Inferred from Direct Assay more info	PubMed
enables phosphopyruvate hydratase activity	IEA Inferred from Electronic Annotation more info
enables phosphopyruvate hydratase activity	IGI Inferred from Genetic Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in biological_process	ND No biological Data available more info
involved_in glycolytic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in glycolytic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	HDA more info	PubMed
part_of phosphopyruvate hydratase complex	IBA Inferred from Biological aspect of Ancestor more info
part_of phosphopyruvate hydratase complex	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: phosphopyruvate hydratase ERR3

NP_014056.3

EC 4.2.1.11

Enolase, a phosphopyruvate hydratase; catalyzes the conversion of 2-phosphoglycerate to phosphoenolpyruvate; complements the growth defect of an ENO1 ENO2 double mutant in glucose

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001145.3 Reference assembly

Range

920088..921401

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001182836.3 → NP_014056.3 TPA: phosphopyruvate hydratase ERR3 [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_014056.3

Status: REVIEWED

UniProtKB/Swiss-Prot

D6W0F0, P42222

UniProtKB/TrEMBL

A6ZLP5, A6ZVX7

Conserved Domains (1) summary

PTZ00081
Location:1 → 428

PTZ00081; enolase; Provisional