U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    TREML1 triggering receptor expressed on myeloid cells like 1 [ Homo sapiens (human) ]

    Gene ID: 340205, updated on 27-Nov-2024

    Summary

    Official Symbol
    TREML1provided by HGNC
    Official Full Name
    triggering receptor expressed on myeloid cells like 1provided by HGNC
    Primary source
    HGNC:HGNC:20434
    See related
    Ensembl:ENSG00000161911 MIM:609714; AllianceGenome:HGNC:20434
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    TLT1; TLT-1; PRO3438; GLTL1825; dJ238O23.3
    Summary
    This gene encodes a member of the triggering receptor expressed on myeloid cells-like (TREM) family. The encoded protein is a type 1 single Ig domain orphan receptor localized to the alpha-granule membranes of platelets. The encoded protein is involved in platelet aggregation, inflammation, and cellular activation and has been linked to Gray platelet syndrome. Alternative splicing results in multiple transcript variants [provided by RefSeq, Nov 2012]
    Expression
    Biased expression in bone marrow (RPKM 1.9), lymph node (RPKM 1.7) and 10 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See TREML1 in Genome Data Viewer
    Location:
    6p21.1
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (41149260..41155403, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (40977812..40983997, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (41116998..41122087, complement)

    Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene apolipoprotein B mRNA editing enzyme catalytic subunit 2 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24500 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24501 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17172 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17173 Neighboring gene O-acyl-ADP-ribose deacylase 1 Neighboring gene nuclear transcription factor Y subunit alpha Neighboring gene MPRA-validated peak5800 silencer Neighboring gene ADCY10 pseudogene 1 Neighboring gene triggering receptor expressed on myeloid cells 2 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17174 Neighboring gene uncharacterized LOC107986595

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env HIV-1 gp120-treated vaginal epithelial cells show upregulation of triggering receptor expressed on myeloid cells-like 1 (TREML1) expression as compared to untreated control PubMed

    Go to the HIV-1, Human Interaction Database

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC119173

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables transmembrane signaling receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Process Evidence Code Pubs
    involved_in calcium-mediated signaling IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in innate immune response NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in platelet activation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in platelet activation IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    located_in Golgi apparatus IDA
    Inferred from Direct Assay
    more info
     
    located_in cell surface IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cell surface IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
     
    located_in membrane NAS
    Non-traceable Author Statement
    more info
    PubMed 
    located_in nuclear speck IDA
    Inferred from Direct Assay
    more info
     
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
     
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
     
    located_in platelet alpha granule IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in platelet alpha granule IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    trem-like transcript 1 protein
    Names
    triggering receptor expressed on myeloid cells-like protein 1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001271807.1NP_001258736.1  trem-like transcript 1 protein isoform b precursor

      See identical proteins and their annotated locations for NP_001258736.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an exon in the coding region which results in a frameshift, compared to variant 1. The encoded isoform (b) is shorter and has a distinct C-terminus, compared to isoform a.
      Source sequence(s)
      AL133404, AY358357, BQ023322, DW009745
      Consensus CDS
      CCDS64421.1
      UniProtKB/Swiss-Prot
      Q86YW5
      Related
      ENSP00000362219.4, ENST00000373127.8
      Conserved Domains (1) summary
      cl11960
      Location:25113
      Ig; Immunoglobulin domain
    2. NM_001271808.1NP_001258737.1  trem-like transcript 1 protein isoform c

      See identical proteins and their annotated locations for NP_001258737.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) lacks an in-frame exon in the coding region, compared to variant 1. The encoded isoform (c) is shorter compared to isoform a.
      Source sequence(s)
      AL133404, AY358357, BC100946, BQ023322, DW009745
      Consensus CDS
      CCDS64420.1
      UniProtKB/Swiss-Prot
      Q86YW5
      Related
      ENSP00000400405.1, ENST00000437044.2
    3. NM_178174.4NP_835468.1  trem-like transcript 1 protein isoform a precursor

      See identical proteins and their annotated locations for NP_835468.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a).
      Source sequence(s)
      AL133404
      Consensus CDS
      CCDS4851.1
      UniProtKB/Swiss-Prot
      Q496B3, Q86YW5, Q8IWY1, Q8IWY2
      Related
      ENSP00000402855.2, ENST00000426005.7
      Conserved Domains (1) summary
      cl11960
      Location:25113
      Ig; Immunoglobulin domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

      Range
      41149260..41155403 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017010825.2XP_016866314.1  trem-like transcript 1 protein isoform X3

    2. XM_017010822.2XP_016866311.1  trem-like transcript 1 protein isoform X1

    3. XM_017010823.2XP_016866312.1  trem-like transcript 1 protein isoform X2

      UniProtKB/Swiss-Prot
      Q496B3, Q86YW5, Q8IWY1, Q8IWY2
      Conserved Domains (1) summary
      cl11960
      Location:25113
      Ig; Immunoglobulin domain

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060930.1 Alternate T2T-CHM13v2.0

      Range
      40977812..40983997 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054355322.1XP_054211297.1  trem-like transcript 1 protein isoform X3

    2. XM_054355320.1XP_054211295.1  trem-like transcript 1 protein isoform X1

    3. XM_054355321.1XP_054211296.1  trem-like transcript 1 protein isoform X2

      UniProtKB/Swiss-Prot
      Q496B3, Q86YW5, Q8IWY1, Q8IWY2