NUP188 Nup188p [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: NUP188
Official Full Name: Nup188p
Primary source: SGD:S000004571
Locus tag: YML103C
See related: AllianceGenome:SGD:S000004571; FungiDB:YML103C; VEuPathDB:YML103C
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: A structural constituent of nuclear pore. Involved in mRNA export from nucleus in response to heat stress; nuclear pore organization; and protein import into nucleus. Part of nuclear pore inner ring. Human ortholog(s) of this gene implicated in Sandestig-Stefanova syndrome and respiratory failure. Orthologous to human NUP188 (nucleoporin 188). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See NUP188 in Genome Data Viewer

Location:: chromosome: XIII

Exon count:: 1

Sequence:: Chromosome: XIII; NC_001145.3 (62582..67549, complement)

Chromosome XIII - NC_001145.3 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001145.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

that the nup188-brr7 allele causes defects in select protein import pathways as well as mRNA export.
Title: Identification of the Novel Nup188-brr7 Allele in a Screen for Cold-Sensitive mRNA Export Mutants in Saccharomyces cerevisiae.
both Nup188 and Nup192 specifically bind FG-repeats and are able to translocate through NPCs by facilitated diffusion
Title: Scaffold nucleoporins Nup188 and Nup192 share structural and functional properties with nuclear transport receptors.
Nup188 exhibits a twisted S-like structure, which flexibly binds the linker nucleoporin Nic96 via a short conserved alpha-helix motif.
Title: Analysis of the yeast nucleoporin Nup188 reveals a conserved S-like structure with similarity to karyopherins.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables structural constituent of nuclear pore	IBA Inferred from Biological aspect of Ancestor more info
enables structural constituent of nuclear pore	IEA Inferred from Electronic Annotation more info
enables structural constituent of nuclear pore	IGI Inferred from Genetic Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in RNA export from nucleus	IBA Inferred from Biological aspect of Ancestor more info
involved_in mRNA export from nucleus in response to heat stress	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mRNA transport	IEA Inferred from Electronic Annotation more info
involved_in nuclear pore organization	IGI Inferred from Genetic Interaction more info	PubMed
involved_in nuclear pore organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein import into nucleus	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein import into nucleus	IGI Inferred from Genetic Interaction more info	PubMed
involved_in protein transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in nuclear membrane	IEA Inferred from Electronic Annotation more info
part_of nuclear pore	IDA Inferred from Direct Assay more info	PubMed
part_of nuclear pore	IEA Inferred from Electronic Annotation more info
part_of nuclear pore inner ring	IBA Inferred from Biological aspect of Ancestor more info
part_of nuclear pore inner ring	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Nup188p

NP_013604.1

Subunit of the inner ring of the nuclear pore complex (NPC); contributes to NPC organization and nucleocytoplasmic transport; homologous to human NUP188

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001145.3 Reference assembly

Range

62582..67549 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001182465.1 → NP_013604.1 TPA: Nup188p [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_013604.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D6W0I1, P52593

UniProtKB/TrEMBL

A6ZLW1

Conserved Domains (2) summary

pfam10487
Location:39 → 976

Nup188; Nucleoporin subcomplex protein binding to Pom34

pfam18378
Location:1407 → 1498

Nup188_C; Nuclear pore protein NUP188 C-terminal domain