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    Gpr85 G protein-coupled receptor 85 [ Mus musculus (house mouse) ]

    Gene ID: 64450, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Gpr85provided by MGI
    Official Full Name
    G protein-coupled receptor 85provided by MGI
    Primary source
    MGI:MGI:1927851
    See related
    Ensembl:ENSMUSG00000048216 AllianceGenome:MGI:1927851
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    2900026B03Rik
    Summary
    Predicted to enable G protein-coupled receptor activity. Predicted to be involved in G protein-coupled receptor signaling pathway. Predicted to be located in endoplasmic reticulum. Predicted to be active in plasma membrane. Is expressed in several structures, including adrenal medulla; central nervous system; musculoskeletal system; peripheral nervous system ganglion; and trunk mesenchyme. Orthologous to human GPR85 (G protein-coupled receptor 85). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in CNS E18 (RPKM 18.7), whole brain E14.5 (RPKM 12.1) and 5 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Gpr85 in Genome Data Viewer
    Location:
    6 A1; 6 5.76 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (13834405..13839951, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (13834406..13839942, complement)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_15197 Neighboring gene base methyltransferase of 25S rRNA 2 Neighboring gene STARR-positive B cell enhancer ABC_E2186 Neighboring gene STARR-positive B cell enhancer ABC_E4812 Neighboring gene STARR-positive B cell enhancer mm9_chr6:13645143-13645444 Neighboring gene STARR-seq mESC enhancer starr_15198 Neighboring gene predicted gene, 53312 Neighboring gene STARR-seq mESC enhancer starr_15199 Neighboring gene STARR-seq mESC enhancer starr_15200 Neighboring gene STARR-seq mESC enhancer starr_15201 Neighboring gene STARR-seq mESC enhancer starr_15202 Neighboring gene STARR-seq mESC enhancer starr_15203 Neighboring gene STARR-seq mESC enhancer starr_15204 Neighboring gene RIKEN cDNA 1110019D14 gene Neighboring gene STARR-seq mESC enhancer starr_15205 Neighboring gene small integral membrane protein 30

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Development of novel potent ligands for GPR85, an orphan G protein-coupled receptor expressed in the brain. Sakai A, et al. Genes Cells, 2022 May. PMID 35194900
    2. Gpr85, a novel member of the G-protein coupled receptor family, prominently expressed in the developing mouse cerebral cortex. Hellebrand S, et al. Brain Res Gene Expr Patterns, 2001 Aug. PMID 15018813
    3. SREB2/GPR85, a schizophrenia risk factor, negatively regulates hippocampal adult neurogenesis and neurogenesis-dependent learning and memory. Chen Q, et al. Eur J Neurosci, 2012 Sep. PMID 22697179, Free PMC Article
    4. Expression analysis of G Protein-Coupled Receptors in mouse macrophages. Lattin JE, et al. Immunome Res, 2008 Apr 29. PMID 18442421, Free PMC Article
    5. Anatomical and histological profiling of orphan G-protein-coupled receptor expression in gastrointestinal tract of C57BL/6J mice. Ito J, et al. Cell Tissue Res, 2009 Nov. PMID 19763624

    See all (28) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Development of novel potent ligands for GPR85, an orphan G protein-coupled receptor expressed in the brain.
      Title: Development of novel potent ligands for GPR85, an orphan G protein-coupled receptor expressed in the brain.
    2. The results indicate that SREB2 is a negative regulator of adult neurogenesis and consequential cognitive functions.
      Title: SREB2/GPR85, a schizophrenia risk factor, negatively regulates hippocampal adult neurogenesis and neurogenesis-dependent learning and memory.
    3. Theses data implicate SREB2 as a potential risk factor for psychiatric disorders.
      Title: The evolutionarily conserved G protein-coupled receptor SREB2/GPR85 influences brain size, behavior, and vulnerability to schizophrenia.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (4) 
    • Targeted (2)  1 citation

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • DKFZp761L08121

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables G protein-coupled receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables G protein-coupled receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endoplasmic reticulum ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane ISA
    Inferred from Sequence Alignment
    more info
    		 PubMed 
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    probable G-protein coupled receptor 85
    Names
    super conserved receptor expressed in brain 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001330666.1 → NP_001317595.1  probable G-protein coupled receptor 85

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate splice site in the 5' UTR, compared to variant 1. Variants 1, 2, and 3 encode the same protein.
      Source sequence(s)
      AC113309, BC065154, BY125022
      Consensus CDS
      CCDS19916.1
      UniProtKB/Swiss-Prot
      P60894
      UniProtKB/TrEMBL
      Q6ZWR2
      Conserved Domains (1) summary
      cd15218
      Location:21 → 350
      7tmA_SREB2_GPR85; super conserved receptor expressed in brain 2 (or GPR85), member of the class A family of seven-transmembrane G protein-coupled receptors

    2. NM_001330667.1 → NP_001317596.1  probable G-protein coupled receptor 85

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks an alternate exon in the 5' UTR, compared to variant 1. Variants 1, 2, and 3 encode the same protein.
      Source sequence(s)
      AC113309, BC065154, BY125022, CF738797
      Consensus CDS
      CCDS19916.1
      UniProtKB/Swiss-Prot
      P60894
      UniProtKB/TrEMBL
      Q6ZWR2
      Conserved Domains (1) summary
      cd15218
      Location:21 → 350
      7tmA_SREB2_GPR85; super conserved receptor expressed in brain 2 (or GPR85), member of the class A family of seven-transmembrane G protein-coupled receptors

    3. NM_145066.5 → NP_659503.1  probable G-protein coupled receptor 85

      See identical proteins and their annotated locations for NP_659503.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2, and 3 encode the same protein.
      Source sequence(s)
      AC113309, BC065154, BY125022
      Consensus CDS
      CCDS19916.1
      UniProtKB/Swiss-Prot
      P60894
      UniProtKB/TrEMBL
      Q6ZWR2
      Related
      ENSMUSP00000053837.8, ENSMUST00000060442.14
      Conserved Domains (1) summary
      cd15218
      Location:21 → 350
      7tmA_SREB2_GPR85; super conserved receptor expressed in brain 2 (or GPR85), member of the class A family of seven-transmembrane G protein-coupled receptors

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      13834405..13839951 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036152258.1 → XP_036008151.1  probable G-protein coupled receptor 85 isoform X1

      UniProtKB/Swiss-Prot
      P60894
      UniProtKB/TrEMBL
      Q6ZWR2
      Related
      ENSMUSP00000111154.2, ENSMUST00000115491.2
      Conserved Domains (1) summary
      cd15218
      Location:21 → 350
      7tmA_SREB2_GPR85; super conserved receptor expressed in brain 2 (or GPR85), member of the class A family of seven-transmembrane G protein-coupled receptors

    2. XM_017321705.3 → XP_017177194.1  probable G-protein coupled receptor 85 isoform X1

      UniProtKB/Swiss-Prot
      P60894
      UniProtKB/TrEMBL
      Q6ZWR2
      Conserved Domains (1) summary
      cd15218
      Location:21 → 350
      7tmA_SREB2_GPR85; super conserved receptor expressed in brain 2 (or GPR85), member of the class A family of seven-transmembrane G protein-coupled receptors

    3. XM_030255527.2 → XP_030111387.1  probable G-protein coupled receptor 85 isoform X1

      UniProtKB/Swiss-Prot
      P60894
      UniProtKB/TrEMBL
      Q6ZWR2
      Related
      ENSMUSP00000111155.2, ENSMUST00000115492.2
      Conserved Domains (1) summary
      cd15218
      Location:21 → 350
      7tmA_SREB2_GPR85; super conserved receptor expressed in brain 2 (or GPR85), member of the class A family of seven-transmembrane G protein-coupled receptors

    4. XM_011241079.4 → XP_011239381.1  probable G-protein coupled receptor 85 isoform X1

      See identical proteins and their annotated locations for XP_011239381.1

      UniProtKB/Swiss-Prot
      P60894
      UniProtKB/TrEMBL
      Q6ZWR2
      Conserved Domains (1) summary
      cd15218
      Location:21 → 350
      7tmA_SREB2_GPR85; super conserved receptor expressed in brain 2 (or GPR85), member of the class A family of seven-transmembrane G protein-coupled receptors

    5. XM_030255529.2 → XP_030111389.1  probable G-protein coupled receptor 85 isoform X1

      UniProtKB/Swiss-Prot
      P60894
      UniProtKB/TrEMBL
      Q6ZWR2
      Conserved Domains (1) summary
      cd15218
      Location:21 → 350
      7tmA_SREB2_GPR85; super conserved receptor expressed in brain 2 (or GPR85), member of the class A family of seven-transmembrane G protein-coupled receptors

    6. XM_030255528.2 → XP_030111388.1  probable G-protein coupled receptor 85 isoform X1

      UniProtKB/Swiss-Prot
      P60894
      UniProtKB/TrEMBL
      Q6ZWR2
      Conserved Domains (1) summary
      cd15218
      Location:21 → 350
      7tmA_SREB2_GPR85; super conserved receptor expressed in brain 2 (or GPR85), member of the class A family of seven-transmembrane G protein-coupled receptors

    7. XM_030255530.2 → XP_030111390.1  probable G-protein coupled receptor 85 isoform X1

      UniProtKB/Swiss-Prot
      P60894
      UniProtKB/TrEMBL
      Q6ZWR2
      Conserved Domains (1) summary
      cd15218
      Location:21 → 350
      7tmA_SREB2_GPR85; super conserved receptor expressed in brain 2 (or GPR85), member of the class A family of seven-transmembrane G protein-coupled receptors
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P60894.1 GenPept UniProtKB/Swiss-Prot:P60894

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