Syt8 synaptotagmin VIII [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Syt8provided by MGI
Official Full Name: synaptotagmin VIIIprovided by MGI
Primary source: MGI:MGI:1859867
See related: Ensembl:ENSMUSG00000031098 AllianceGenome:MGI:1859867
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary: Enables calcium-dependent protein binding activity. Involved in acrosome reaction. Located in cytoplasm and vesicle. Is expressed in bladder. Orthologous to human SYT8 (synaptotagmin 8). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in stomach adult (RPKM 74.9), bladder adult (RPKM 52.7) and 2 other tissues See more
Orthologs: human all
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Genomic context

Location:: 7 F5; 7 87.93 cM

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	7	NC_000073.7 (141988195..141994136)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	7	NC_000073.6 (142434850..142440396)

Chromosome 7 - NC_000073.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Syt VIII is a candidate for the Ca(2+) sensor that regulates acrosomal exocytosis in mammalian sperm
Title: Synaptotagmin VIII is localized to the mouse sperm head and may function in acrosomal exocytosis.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables SNARE binding	IBA Inferred from Biological aspect of Ancestor more info
enables calcium ion sensor activity	IBA Inferred from Biological aspect of Ancestor more info
enables calcium-dependent phospholipid binding	IBA Inferred from Biological aspect of Ancestor more info
enables calcium-dependent protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables clathrin binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in acrosome reaction	IDA Inferred from Direct Assay more info	PubMed
involved_in calcium-dependent activation of synaptic vesicle fusion	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of calcium ion-dependent exocytosis	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of synaptic vesicle exocytosis	IBA Inferred from Biological aspect of Ancestor more info
involved_in vesicle-mediated transport	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in acrosomal vesicle	IEA Inferred from Electronic Annotation more info
is_active_in axon	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
is_active_in dense core granule	IBA Inferred from Biological aspect of Ancestor more info
is_active_in exocytic vesicle	IBA Inferred from Biological aspect of Ancestor more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
is_active_in synaptic vesicle membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in vesicle	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: synaptotagmin-8

Names: sytVIII

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001285857.1 → NP_001272786.1 synaptotagmin-8 isoform b

See identical proteins and their annotated locations for NP_001272786.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR and uses an alternate in-frame splice junction at the 5' end of an exon compared to variant 1. The resulting isoform (b) has the same N- and C-termini but is shorter compared to isoform a. Variants 2 and 3 both encode the same isoform (b).

Source sequence(s)

AK075832

Consensus CDS

CCDS72071.1

UniProtKB/TrEMBL

F2Z3W8, Q496Q3

Related

ENSMUSP00000101596.2, ENSMUST00000105976.8

Conserved Domains (1) summary

cl14603
Location:236 → 366

C2; C2 domain
NM_001285858.1 → NP_001272787.1 synaptotagmin-8 isoform b

See identical proteins and their annotated locations for NP_001272787.1

Status: VALIDATED

Description

Transcript Variant: This variant (3) differs in the 5' UTR and uses an alternate in-frame splice junction at the 5' end of an exon compared to variant 1. The resulting isoform (b) has the same N- and C-termini but is shorter compared to isoform a. Variants 2 and 3 both encode the same isoform (b).

Source sequence(s)

AK075832

Consensus CDS

CCDS72071.1

UniProtKB/TrEMBL

F2Z3W8, Q496Q3

Related

ENSMUSP00000095552.3, ENSMUST00000097939.9

Conserved Domains (1) summary

cl14603
Location:236 → 366

C2; C2 domain
NM_001285861.1 → NP_001272790.1 synaptotagmin-8 isoform c

See identical proteins and their annotated locations for NP_001272790.1

Status: VALIDATED

Description

Transcript Variant: This variant (4) differs in the 5' UTR and coding sequence and uses an alternate in-frame splice junction at the 5' end of an exon compared to variant 1. The resulting isoform (c) has a longer and distinct N-terminus and lacks an alternate internal segment compared to isoform a.

Source sequence(s)

AK075832, AL603651

Consensus CDS

CCDS72070.1

UniProtKB/Swiss-Prot

A9JAL0, Q64366, Q8C6E7, Q9R0N6

UniProtKB/TrEMBL

Q496Q3

Related

ENSMUSP00000112689.2, ENSMUST00000122393.2

Conserved Domains (2) summary

cl14603
Location:242 → 372

C2; C2 domain

cl25995
Location:49 → 82

TM_EphA1; Transmembrane domain of Ephrin Receptor A1 Protein Tyrosine Kinase
NM_018802.5 → NP_061272.2 synaptotagmin-8 isoform a

See identical proteins and their annotated locations for NP_061272.2

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (a).

Source sequence(s)

AK075832

Consensus CDS

CCDS22030.1

UniProtKB/TrEMBL

Q496Q3

Related

ENSMUSP00000113545.2, ENSMUST00000118276.8

Conserved Domains (1) summary

cl14603
Location:242 → 372

C2; C2 domain

RNA

NR_153437.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

AA023701, AL603651

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000073.7 Reference GRCm39 C57BL/6J

Range

141988195..141994136

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036153263.1 → XP_036009156.1 synaptotagmin-8 isoform X6

Conserved Domains (1) summary

cl14603
Location:122 → 240

C2; C2 domain
XM_036153264.1 → XP_036009157.1 synaptotagmin-8 isoform X7

Conserved Domains (1) summary

cl14603
Location:122 → 240

C2; C2 domain
XM_036153265.1 → XP_036009158.1 synaptotagmin-8 isoform X8

Conserved Domains (1) summary

cl14603
Location:122 → 240

C2; C2 domain
XM_006508632.5 → XP_006508695.1 synaptotagmin-8 isoform X1

See identical proteins and their annotated locations for XP_006508695.1

UniProtKB/TrEMBL

Q496Q3

Conserved Domains (1) summary

cl14603
Location:249 → 379

C2; C2 domain
XM_006508633.5 → XP_006508696.1 synaptotagmin-8 isoform X1

See identical proteins and their annotated locations for XP_006508696.1

UniProtKB/TrEMBL

Q496Q3

Conserved Domains (1) summary

cl14603
Location:249 → 379

C2; C2 domain
XM_011242014.4 → XP_011240316.1 synaptotagmin-8 isoform X2

UniProtKB/TrEMBL

Q496Q3

Conserved Domains (2) summary

cl14603
Location:248 → 378

C2; C2 domain

cl25995
Location:55 → 88

TM_EphA1; Transmembrane domain of Ephrin Receptor A1 Protein Tyrosine Kinase
XM_006508638.4 → XP_006508701.1 synaptotagmin-8 isoform X3

See identical proteins and their annotated locations for XP_006508701.1

UniProtKB/TrEMBL

Q496Q3

Conserved Domains (2) summary

cl14603
Location:243 → 373

C2; C2 domain

cl25995
Location:50 → 83

TM_EphA1; Transmembrane domain of Ephrin Receptor A1 Protein Tyrosine Kinase
XM_006508639.4 → XP_006508702.1 synaptotagmin-8 isoform X3

See identical proteins and their annotated locations for XP_006508702.1

UniProtKB/TrEMBL

Q496Q3

Conserved Domains (2) summary

cl14603
Location:243 → 373

C2; C2 domain

cl25995
Location:50 → 83

TM_EphA1; Transmembrane domain of Ephrin Receptor A1 Protein Tyrosine Kinase
XM_011242015.4 → XP_011240317.1 synaptotagmin-8 isoform X3

See identical proteins and their annotated locations for XP_011240317.1

UniProtKB/TrEMBL

Q496Q3

Conserved Domains (2) summary

cl14603
Location:243 → 373

C2; C2 domain

cl25995
Location:50 → 83

TM_EphA1; Transmembrane domain of Ephrin Receptor A1 Protein Tyrosine Kinase
XM_006508635.5 → XP_006508698.1 synaptotagmin-8 isoform X3

See identical proteins and their annotated locations for XP_006508698.1

UniProtKB/TrEMBL

Q496Q3

Conserved Domains (2) summary

cl14603
Location:243 → 373

C2; C2 domain

cl25995
Location:50 → 83

TM_EphA1; Transmembrane domain of Ephrin Receptor A1 Protein Tyrosine Kinase
XM_006508637.5 → XP_006508700.1 synaptotagmin-8 isoform X3

See identical proteins and their annotated locations for XP_006508700.1

UniProtKB/TrEMBL

Q496Q3

Conserved Domains (2) summary

cl14603
Location:243 → 373

C2; C2 domain

cl25995
Location:50 → 83

TM_EphA1; Transmembrane domain of Ephrin Receptor A1 Protein Tyrosine Kinase
XM_036153262.1 → XP_036009155.1 synaptotagmin-8 isoform X5

UniProtKB/TrEMBL

Q496Q4

Conserved Domains (1) summary

cl14603
Location:138 → 268

C2; C2 domain
XM_011242016.4 → XP_011240318.1 synaptotagmin-8 isoform X4

See identical proteins and their annotated locations for XP_011240318.1

UniProtKB/Swiss-Prot

A9JAL0, Q64366, Q8C6E7, Q9R0N6

UniProtKB/TrEMBL

Q496Q3

Conserved Domains (2) summary

cl14603
Location:242 → 372

C2; C2 domain

cl25995
Location:49 → 82

TM_EphA1; Transmembrane domain of Ephrin Receptor A1 Protein Tyrosine Kinase
XM_036153261.1 → XP_036009154.1 synaptotagmin-8 isoform X1

UniProtKB/TrEMBL

Q496Q3

Conserved Domains (1) summary

cl14603
Location:249 → 379

C2; C2 domain