U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Fam220a family with sequence similarity 220, member A [ Mus musculus (house mouse) ]

    Gene ID: 67238, updated on 27-Dec-2024

    Summary

    Official Symbol
    Fam220aprovided by MGI
    Official Full Name
    family with sequence similarity 220, member Aprovided by MGI
    Primary source
    MGI:MGI:1914488
    See related
    Ensembl:ENSMUSG00000083012 AllianceGenome:MGI:1914488
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Sipar; Acpin1; 1500026F15Rik; 2810453I06Rik
    Summary
    Enables STAT family protein binding activity. Involved in intracellular signal transduction. Acts upstream of or within negative regulation of transcription by RNA polymerase II and protein dephosphorylation. Located in acrosomal vesicle and nucleus. Is expressed in several structures, including brain; genitourinary system; gut; hemolymphoid system gland; and liver. Orthologous to several human genes including FAM220A (family with sequence similarity 220 member A). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in testis adult (RPKM 61.1), spleen adult (RPKM 25.7) and 24 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Fam220a in Genome Data Viewer
    Location:
    5 G2; 5 82.27 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (143534475..143550286)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (143548720..143564531)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene diacylglycerol lipase, beta Neighboring gene Rac family small GTPase 1 Neighboring gene STARR-seq mESC enhancer starr_14793 Neighboring gene small integral membrane protein 10 like 3 Neighboring gene predicted gene, 54311 Neighboring gene cytohesin 3

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables STAT family protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables STAT family protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in acrosomal vesicle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    protein FAM220A
    Names
    STAT3-interacting protein as a repressor
    acrosomal protein ACPIN1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_026050.3NP_080326.2  protein FAM220A

      See identical proteins and their annotated locations for NP_080326.2

      Status: VALIDATED

      Source sequence(s)
      AC217112
      Consensus CDS
      CCDS51690.1
      UniProtKB/Swiss-Prot
      B2RVG9, Q3ZN08, Q8BPE1, Q99JV7, Q9D5Z1
      UniProtKB/TrEMBL
      B7ZWE3
      Related
      ENSMUSP00000143202.2, ENSMUST00000196487.2
      Conserved Domains (1) summary
      pfam15487
      Location:2258
      FAM220; FAM220 family
    2. NM_133703.5NP_598464.3  protein FAM220A

      See identical proteins and their annotated locations for NP_598464.3

      Status: VALIDATED

      Source sequence(s)
      AC217112
      Consensus CDS
      CCDS51690.1
      UniProtKB/Swiss-Prot
      B2RVG9, Q3ZN08, Q8BPE1, Q99JV7, Q9D5Z1
      UniProtKB/TrEMBL
      B7ZWE3
      Related
      ENSMUSP00000142548.2, ENSMUST00000200267.2
      Conserved Domains (1) summary
      pfam15487
      Location:2258
      FAM220; FAM220 family

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      143534475..143550286
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)