Traip TRAF-interacting protein [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Traipprovided by MGI
Official Full Name: TRAF-interacting proteinprovided by MGI
Primary source: MGI:MGI:1096377
See related: Ensembl:ENSMUSG00000032586 AllianceGenome:MGI:1096377
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Trip
Summary: Enables ubiquitin protein ligase activity. Involved in negative regulation of interferon-beta production and protein ubiquitination. Acts upstream of or within negative regulation of NF-kappaB transcription factor activity and signal transduction. Predicted to be located in nucleolus and nucleoplasm. Predicted to be active in nucleus and site of DNA damage. Is expressed in several structures, including central nervous system; genitourinary system; liver; retina layer; and spleen. Human ortholog(s) of this gene implicated in Seckel syndrome 9. Orthologous to human TRAIP (TRAF interacting protein). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Broad expression in CNS E11.5 (RPKM 3.7), frontal lobe adult (RPKM 3.7) and 19 other tissues See more
Orthologs: human all
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Genomic context

Location:: 9 F1; 9 59.07 cM

Exon count:: 16

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	9	NC_000075.7 (107828158..107849469)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	9	NC_000075.6 (107950325..107972270)

Chromosome 9 - NC_000075.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

TRAIP suppressed apoptosis and cell cycle to promote prostate cancer proliferation via TRAF2-PI3K-AKT pathway activation.
Title: TRAIP suppressed apoptosis and cell cycle to promote prostate cancer proliferation via TRAF2-PI3K-AKT pathway activation.
Taken together, these data indicate that TRAIP plays important roles in oocyte meiosis regulation.
Title: TRAIP is involved in chromosome alignment and SAC regulation in mouse oocyte meiosis.
TRIP as a negative regulator in TLR3/4- and RIG-I-triggered antiviral responses and suggested TRIP as a potential target for the intervention of diseases with uncontrolled IFN-beta production.
Title: TRAF-interacting protein (TRIP) negatively regulates IFN-β production and antiviral response by promoting proteasomal degradation of TANK-binding kinase 1.
TRIP is an essential factor during early mouse embryonic development in vivo
Title: Early embryonic lethality caused by targeted disruption of the TRAF-interacting protein (TRIP) gene.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Targeted (1) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Traip (e-PCR), detects polymorphism
- UniSTS:516550

BB074618 (e-PCR)
- UniSTS:185808

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables identical protein binding	IEA Inferred from Electronic Annotation more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables ubiquitin protein ligase activity	IBA Inferred from Biological aspect of Ancestor more info
enables ubiquitin protein ligase activity	IDA Inferred from Direct Assay more info	PubMed
enables ubiquitin-protein transferase activity	IDA Inferred from Direct Assay more info	PubMed
enables ubiquitin-protein transferase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in DNA damage response	ISO Inferred from Sequence Orthology more info
involved_in DNA damage response	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within negative regulation of NF-kappaB transcription factor activity	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of interferon-beta production	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of tumor necrosis factor-mediated signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of tumor necrosis factor-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in protein ubiquitination	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein ubiquitination	IDA Inferred from Direct Assay more info	PubMed
involved_in protein ubiquitination	IEA Inferred from Electronic Annotation more info
involved_in protein ubiquitination	ISO Inferred from Sequence Orthology more info
involved_in protein-DNA covalent cross-linking repair	ISS Inferred from Sequence or Structural Similarity more info
involved_in replication fork processing	IBA Inferred from Biological aspect of Ancestor more info
involved_in replication fork processing	ISO Inferred from Sequence Orthology more info
involved_in replication fork processing	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within signal transduction	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within signal transduction	IPI Inferred from Physical Interaction more info	PubMed

Component	Evidence Code	Pubs
located_in nucleolus	ISO Inferred from Sequence Orthology more info
located_in nucleolus	ISS Inferred from Sequence or Structural Similarity more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISS Inferred from Sequence or Structural Similarity more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in perinuclear region of cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in site of DNA damage	IBA Inferred from Biological aspect of Ancestor more info
located_in site of DNA damage	ISO Inferred from Sequence Orthology more info
located_in site of DNA damage	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: E3 ubiquitin-protein ligase TRAIP

Names: RING-type E3 ubiquitin transferase TRAIP

NP_001397399.1

EC 2.3.2.27

NP_001397400.1

EC 2.3.2.27

NP_001397401.1

EC 2.3.2.27

NP_001397402.1

EC 2.3.2.27

NP_035764.2

EC 2.3.2.27

XP_017168773.1

EC 2.3.2.27

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001410470.1 → NP_001397399.1 E3 ubiquitin-protein ligase TRAIP isoform 2

Status: VALIDATED

Source sequence(s)

AL731808
NM_001410471.1 → NP_001397400.1 E3 ubiquitin-protein ligase TRAIP isoform 3

Status: VALIDATED

Source sequence(s)

AL731808
NM_001410472.1 → NP_001397401.1 E3 ubiquitin-protein ligase TRAIP isoform 4

Status: VALIDATED

Source sequence(s)

AL731808
NM_001410473.1 → NP_001397402.1 E3 ubiquitin-protein ligase TRAIP isoform 4

Status: VALIDATED

Source sequence(s)

AL731808
NM_011634.4 → NP_035764.2 E3 ubiquitin-protein ligase TRAIP isoform 1

See identical proteins and their annotated locations for NP_035764.2

Status: VALIDATED

Source sequence(s)

AL731808

Consensus CDS

CCDS23511.1

UniProtKB/Swiss-Prot

O08854, Q8VIG6, Q922M8, Q9CPP4

Related

ENSMUSP00000040001.4, ENSMUST00000049348.9

Conserved Domains (2) summary

pfam08647
Location:204 → 271

BRE1; BRE1 E3 ubiquitin ligase

pfam13639
Location:7 → 50

zf-RING_2; Ring finger domain

RNA

NR_177076.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

AL731808

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000075.7 Reference GRCm39 C57BL/6J

Range

107828158..107849469

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017313284.2 → XP_017168773.1 E3 ubiquitin-protein ligase TRAIP isoform X2

Conserved Domains (1) summary

COG1196
Location:6 → 150

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]