Srfbp1 serum response factor binding protein 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Srfbp1provided by MGI
Official Full Name: serum response factor binding protein 1provided by MGI
Primary source: MGI:MGI:1914472
See related: Ensembl:ENSMUSG00000024528 AllianceGenome:MGI:1914472
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: p49/STRAP; 2810036K01Rik
Summary: Predicted to be involved in maturation of SSU-rRNA. Located in nucleus. Is expressed in several structures, including axial musculature; genitourinary system; neural ectoderm; orbito-sphenoid; and submandibular gland primordium. Orthologous to human SRFBP1 (serum response factor binding protein 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Broad expression in CNS E11.5 (RPKM 7.6), placenta adult (RPKM 5.3) and 21 other tissues See more
Orthologs: human all
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Genomic context

Location:: 18 D1; 18 28.21 cM

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	18	NC_000084.7 (52598703..52625005)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	18	NC_000084.6 (52465631..52491933)

Chromosome 18 - NC_000084.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

P49/STRAP expression was increased in the old versus young adult mouse hearts and also increased with advancing population doubling levels in cultured human umbilical vein endothelial cells. The increased expression of p49/STRAP in late life may alter the status of histone acetylation and impact mitochondrial dynamics and thereby reduce mitochondrial function and cardiac performance during mammalian senescence.
Title: Does p49/STRAP, a SRF-binding protein (SRFBP1), modulate cardiac mitochondrial function in aging?
Overexpression of p49/STRAP reduced actin content in cultured cells and resulted in smaller cell size versus control cells.
Title: Overexpression of p49/STRAP alters cellular cytoskeletal structure and gross anatomy in mice.
49-kDa protein (p49/STRAP) specifically interacts with an acidic amino acid motif (Q7IGSEDG) in the N-terminus of GLUT4.
Title: Identification and characterization of p49/STRAP as a novel GLUT4-binding protein.
p49/STRAP may be an important SRF cofactor in the transcriptional regulation of mammalian cardiac muscle genes throughout the life span
Title: Identification of a novel serum response factor cofactor in cardiac gene regulation.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Srfbp1 (e-PCR), detects polymorphism
- UniSTS:526024

NoName (e-PCR)
- UniSTS:237801

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in maturation of SSU-rRNA	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
part_of 90S preribosome	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in perinuclear region of cytoplasm	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: serum response factor-binding protein 1

Names: SRF-dependent transcription regulation associated protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.