Get3 guided entry of tail-anchored proteins factor 3, ATPase [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Get3provided by MGI
Official Full Name: guided entry of tail-anchored proteins factor 3, ATPaseprovided by MGI
Primary source: MGI:MGI:1928379
See related: Ensembl:ENSMUSG00000052456 AllianceGenome:MGI:1928379
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: ArsA; Asna1; 1810048H22Rik
Summary: Predicted to enable ATP hydrolysis activity and membrane insertase activity. Predicted to be involved in tail-anchored membrane protein insertion into ER membrane. Predicted to act upstream of or within post-translational protein targeting to endoplasmic reticulum membrane. Predicted to be located in nucleolus and nucleoplasm. Predicted to be part of GET complex. Predicted to be active in endoplasmic reticulum membrane. Is expressed in several structures, including central nervous system; foregut; ganglia; respiratory system; and tooth. Human ortholog(s) of this gene implicated in dilated cardiomyopathy. Orthologous to human GET3 (guided entry of tail-anchored proteins factor 3, ATPase). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in kidney adult (RPKM 83.4), testis adult (RPKM 69.8) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 8 C3; 8 41.48 cM

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	8	NC_000074.7 (85744558..85751916, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	8	NC_000074.6 (85017929..85025287, complement)

Chromosome 8 - NC_000074.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

These findings support a role for the Asna1 ATPase activity in ensuring the survival of pancreatic multipotent progenitor cells , possibly by counteracting p53-mediated apoptosis.
Title: The ATPase activity of Asna1/TRC40 is required for pancreatic progenitor cell survival.
Asna1 ensures retrograde transport and ER and insulin homeostasis in beta-cells. Asna1 KO mice develop hypoinsulinemia, impaired insulin secretion, and glucose intolerance that rapidly progresses to overt diabetes.
Title: Asna1/TRC40 Controls β-Cell Function and Endoplasmic Reticulum Homeostasis by Ensuring Retrograde Transport.
These findings indicate that Asna1 plays a crucial role during early embryonic development.
Title: Targeted disruption of the mouse Asna1 gene results in embryonic lethality.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Gene trapped (1)
Targeted (2) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH129284 (e-PCR)
- UniSTS:212591

NoName (e-PCR)
- UniSTS:235944

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP hydrolysis activity	IBA Inferred from Biological aspect of Ancestor more info
enables ATP hydrolysis activity	IEA Inferred from Electronic Annotation more info
enables membrane insertase activity	IEA Inferred from Electronic Annotation more info
enables membrane insertase activity	ISO Inferred from Sequence Orthology more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within post-translational protein targeting to endoplasmic reticulum membrane	ISO Inferred from Sequence Orthology more info	PubMed
involved_in tail-anchored membrane protein insertion into ER membrane	IBA Inferred from Biological aspect of Ancestor more info
involved_in tail-anchored membrane protein insertion into ER membrane	ISO Inferred from Sequence Orthology more info
involved_in tail-anchored membrane protein insertion into ER membrane	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
part_of GET complex	IBA Inferred from Biological aspect of Ancestor more info
part_of GET complex	ISO Inferred from Sequence Orthology more info
part_of GET complex	ISS Inferred from Sequence or Structural Similarity more info
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
is_active_in endoplasmic reticulum membrane	ISO Inferred from Sequence Orthology more info
located_in nucleolus	IEA Inferred from Electronic Annotation more info
located_in nucleolus	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: ATPase GET3

Names: ATPase Asna1; arsenical pump-driving ATPase; arsenite-stimulated ATPase; arsenite-translocating ATPase

NP_001344131.1

EC 7.3.2.7

NP_001344132.1

EC 7.3.2.7

NP_062626.1

EC 7.3.2.7

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001357202.1 → NP_001344131.1 ATPase GET3 isoform 2

Status: VALIDATED

Source sequence(s)

AC163703

UniProtKB/TrEMBL

Q8VEI6

Conserved Domains (1) summary

cl38936
Location:1 → 217

P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
NM_001357203.1 → NP_001344132.1 ATPase GET3 isoform 2

Status: VALIDATED

Source sequence(s)

AC163703

UniProtKB/TrEMBL

Q8VEI6

Conserved Domains (1) summary

cl38936
Location:1 → 217

P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
NM_019652.2 → NP_062626.1 ATPase GET3 isoform 1

See identical proteins and their annotated locations for NP_062626.1

Status: VALIDATED

Source sequence(s)

BC083335, BY230823, BY631769

Consensus CDS

CCDS40417.1

UniProtKB/Swiss-Prot

O54984, Q3TAQ4

Related

ENSMUSP00000065337.9, ENSMUST00000064314.10

Conserved Domains (1) summary

pfam02374
Location:37 → 340

ArsA_ATPase; Anion-transporting ATPase