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    Rnf113a2 ring finger protein 113A2 [ Mus musculus (house mouse) ]

    Gene ID: 66381, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Rnf113a2provided by MGI
    Official Full Name
    ring finger protein 113A2provided by MGI
    Primary source
    MGI:MGI:1913631
    See related
    Ensembl:ENSMUSG00000098134 AllianceGenome:MGI:1913631
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Rnf113a; 2310020H19Rik
    Summary
    Predicted to enable ubiquitin protein ligase activity. Predicted to be involved in RNA splicing; negative regulation of chemokine-mediated signaling pathway; and protein ubiquitination. Predicted to be located in nucleoplasm. Predicted to be part of U2-type precatalytic spliceosome. Human ortholog(s) of this gene implicated in nonphotosensitive trichothiodystrophy 5. Orthologous to human RNF113A (ring finger protein 113A). [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See Rnf113a2 in Genome Data Viewer
    Location:
    12 D1; 12 39.2 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (84463974..84465352)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (84417200..84418578)

    Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene family with sequence similarity 161, member B Neighboring gene STARR-positive B cell enhancer ABC_E1445 Neighboring gene coenzyme Q6 monooxygenase Neighboring gene CapStarr-seq enhancer MGSCv37_chr12:85729760-85729947 Neighboring gene ectonucleoside triphosphate diphosphohydrolase 5 Neighboring gene STARR-positive B cell enhancer ABC_E8493 Neighboring gene basal body orientation factor 1 Neighboring gene aldehyde dehydrogenase family 6, subfamily A1 Neighboring gene STARR-positive B cell enhancer ABC_E80 Neighboring gene lin-52 DREAM MuvB core complex component Neighboring gene STARR-seq mESC enhancer starr_32738

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Mouse brain organization revealed through direct genome-scale TF expression analysis. Gray PA, et al. Science, 2004 Dec 24. PMID 15618518
    2. Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray. Tanaka TS, et al. Proc Natl Acad Sci U S A, 2000 Aug 1. PMID 10922068, Free PMC Article
    3. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548
    4. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article
    5. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC144613

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ubiquitin protein ligase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in mRNA splicing, via spliceosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of chemokine-mediated signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein ubiquitination ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in snoRNA splicing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of U2-type precatalytic spliceosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of U2-type spliceosomal complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    ring finger protein 113A2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_025525.2 → NP_079801.2  ring finger protein 113A2

      See identical proteins and their annotated locations for NP_079801.2

      Status: VALIDATED

      Source sequence(s)
      AA462834, AK009420, AK016795, BC058194
      Consensus CDS
      CCDS59575.1
      UniProtKB/TrEMBL
      Q14B01, Q9D7A3
      Related
      ENSMUSP00000138536.2, ENSMUST00000183146.2
      Conserved Domains (3) summary
      COG5152
      Location:57 → 323
      COG5152; Uncharacterized conserved protein, contains RING and CCCH-type Zn-fingers [General function prediction only]
      cd00162
      Location:261 → 299
      RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
      pfam00642
      Location:197 → 223
      zf-CCCH; Zinc finger C-x8-C-x5-C-x3-H type (and similar)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000078.7 Reference GRCm39 C57BL/6J

      Range
      84463974..84465352
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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