Ntmt1 N-terminal Xaa-Pro-Lys N-methyltransferase 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ntmt1provided by MGI
Official Full Name: N-terminal Xaa-Pro-Lys N-methyltransferase 1provided by MGI
Primary source: MGI:MGI:1913867
See related: Ensembl:ENSMUSG00000026857 AllianceGenome:MGI:1913867
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: NTM1A; Mettl11a; 2610205E22Rik
Summary: Enables protein methyltransferase activity. Involved in N-terminal peptidyl-alanine trimethylation and N-terminal peptidyl-proline dimethylation. Predicted to be located in cytosol and nucleoplasm. Predicted to be active in cytoplasm. Orthologous to human NTMT1 (N-terminal Xaa-Pro-Lys N-methyltransferase 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Ubiquitous expression in ovary adult (RPKM 27.0), adrenal adult (RPKM 21.3) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 2 B; 2 21.74 cM

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	2	NC_000068.8 (30697576..30713045)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	2	NC_000068.7 (30807945..30823033)

Chromosome 2 - NC_000068.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Chemically induced (ENU) (1)
Gene trapped (1)
Targeted (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH124227 (e-PCR)
- UniSTS:161049

BI277553 (e-PCR)
- UniSTS:243790

RH124851 (e-PCR)
- UniSTS:161673

AA409356 (e-PCR)
- UniSTS:158945

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables N-terminal protein N-methyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables N-terminal protein N-methyltransferase activity	ISO Inferred from Sequence Orthology more info
enables N-terminal protein N-methyltransferase activity	ISS Inferred from Sequence or Structural Similarity more info
enables histone methyltransferase activity	ISO Inferred from Sequence Orthology more info
enables histone methyltransferase activity	ISS Inferred from Sequence or Structural Similarity more info
enables protein methyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein methyltransferase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in N-terminal peptidyl-alanine trimethylation	IDA Inferred from Direct Assay more info	PubMed
involved_in N-terminal peptidyl-glycine methylation	ISO Inferred from Sequence Orthology more info
involved_in N-terminal peptidyl-glycine methylation	ISS Inferred from Sequence or Structural Similarity more info
involved_in N-terminal peptidyl-proline dimethylation	IDA Inferred from Direct Assay more info	PubMed
involved_in N-terminal peptidyl-proline dimethylation	ISO Inferred from Sequence Orthology more info
involved_in N-terminal peptidyl-serine dimethylation	ISO Inferred from Sequence Orthology more info
involved_in N-terminal peptidyl-serine dimethylation	ISS Inferred from Sequence or Structural Similarity more info
involved_in N-terminal peptidyl-serine trimethylation	ISO Inferred from Sequence Orthology more info
involved_in N-terminal peptidyl-serine trimethylation	ISS Inferred from Sequence or Structural Similarity more info
involved_in chromatin remodeling	IEA Inferred from Electronic Annotation more info
involved_in chromosome segregation	ISO Inferred from Sequence Orthology more info
involved_in chromosome segregation	ISS Inferred from Sequence or Structural Similarity more info
involved_in spindle organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in spindle organization	ISO Inferred from Sequence Orthology more info
involved_in spindle organization	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: N-terminal Xaa-Pro-Lys N-methyltransferase 1

Names: X-Pro-Lys N-terminal protein methyltransferase 1A; alpha N-terminal protein methyltransferase 1A; methyltransferase like 11A; methyltransferase-like protein 11A

NP_001343362.1

EC 2.1.1.244

NP_001343363.1

EC 2.1.1.244

NP_001343364.1

EC 2.1.1.244

NP_001343365.1

EC 2.1.1.244

NP_001343366.1

EC 2.1.1.244

NP_733480.1

EC 2.1.1.244

XP_006498291.1

EC 2.1.1.244

XP_030107813.1

EC 2.1.1.244

XP_036018355.1

EC 2.1.1.244

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001356433.1 → NP_001343362.1 N-terminal Xaa-Pro-Lys N-methyltransferase 1 isoform a

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 both encode the same isoform (a).

Source sequence(s)

AL844532

Consensus CDS

CCDS15886.1

UniProtKB/Swiss-Prot

A2APZ4, Q8R2U4

Conserved Domains (1) summary

pfam05891
Location:8 → 223

Methyltransf_PK; AdoMet dependent proline di-methyltransferase
NM_001356434.1 → NP_001343363.1 N-terminal Xaa-Pro-Lys N-methyltransferase 1 isoform b

Status: VALIDATED

Description

Transcript Variant: This variant (3) differs in the 5' UTR and coding sequence and uses two alternate splice junctions compared to variant 1. The resulting isoform (b) has a shorter and distinct N-terminus compared to isoform a.

Source sequence(s)

AL844532

Conserved Domains (1) summary

cl17173
Location:26 → 193

AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
NM_001356435.1 → NP_001343364.1 N-terminal Xaa-Pro-Lys N-methyltransferase 1 isoform c

Status: VALIDATED

Description

Transcript Variant: This variant (4) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (c) is shorter at the N-terminus compared to isoform a. Variants 4, 5, and 6 all encode the same isoform (c).

Source sequence(s)

AL844532, FO719400

Conserved Domains (1) summary

cl17173
Location:1 → 135

AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
NM_001356436.1 → NP_001343365.1 N-terminal Xaa-Pro-Lys N-methyltransferase 1 isoform c

Status: VALIDATED

Description

Transcript Variant: This variant (5) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (c) is shorter at the N-terminus compared to isoform a. Variants 4, 5, and 6 all encode the same isoform (c).

Source sequence(s)

AL844532, FO713235

Conserved Domains (1) summary

cl17173
Location:1 → 135

AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
NM_001356437.1 → NP_001343366.1 N-terminal Xaa-Pro-Lys N-methyltransferase 1 isoform c

Status: VALIDATED

Description

Transcript Variant: This variant (6) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (c) is shorter at the N-terminus compared to isoform a. Variants 4, 5, and 6 all encode the same isoform (c).

Source sequence(s)

AL844532

Conserved Domains (1) summary

cl17173
Location:1 → 135

AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
NM_170592.3 → NP_733480.1 N-terminal Xaa-Pro-Lys N-methyltransferase 1 isoform a

See identical proteins and their annotated locations for NP_733480.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) encodes the longest isoform (a). Variants 1 and 2 both encode the same isoform (a).

Source sequence(s)

AL844532, FO719547

Consensus CDS

CCDS15886.1

UniProtKB/Swiss-Prot

A2APZ4, Q8R2U4

Related

ENSMUSP00000035303.4, ENSMUST00000041830.10

Conserved Domains (1) summary

pfam05891
Location:8 → 223

Methyltransf_PK; AdoMet dependent proline di-methyltransferase

RNA

NR_151467.1 RNA Sequence

Status: VALIDATED

Description

Transcript Variant: This variant (7) differs in the 3' end compared to variant 1. This variant is represented as non-coding because it lacks the entire coding region found in variant 1.

Source sequence(s)

AL844532, BY290960
NR_151468.1 RNA Sequence

Status: VALIDATED

Description

Transcript Variant: This variant (8) differs in the 3' end compared to variant 1. This variant is represented as non-coding because it lacks the entire coding region found in variant 1.

Source sequence(s)

AK161700, AL844532

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000068.8 Reference GRCm39 C57BL/6J

Range

30697576..30713045

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036162462.1 → XP_036018355.1 N-terminal Xaa-Pro-Lys N-methyltransferase 1 isoform X1

UniProtKB/Swiss-Prot

A2APZ4, Q8R2U4

Conserved Domains (1) summary

pfam05891
Location:8 → 223

Methyltransf_PK; AdoMet dependent proline di-methyltransferase
XM_030251953.2 → XP_030107813.1 N-terminal Xaa-Pro-Lys N-methyltransferase 1 isoform X1

UniProtKB/Swiss-Prot

A2APZ4, Q8R2U4

Conserved Domains (1) summary

pfam05891
Location:8 → 223

Methyltransf_PK; AdoMet dependent proline di-methyltransferase
XM_006498228.5 → XP_006498291.1 N-terminal Xaa-Pro-Lys N-methyltransferase 1 isoform X2

Conserved Domains (1) summary

cl17173
Location:26 → 193

AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...