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    Rapgef1 Rap guanine nucleotide exchange factor 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 63881, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Rapgef1provided by RGD
    Official Full Name
    Rap guanine nucleotide exchange factor 1provided by RGD
    Primary source
    RGD:619793
    See related
    EnsemblRapid:ENSRNOG00000014316 AllianceGenome:RGD:619793
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    C3g; Grf2; C3G-1; C3G-2
    Summary
    Predicted to enable guanyl-nucleotide exchange factor activity. Involved in positive regulation of Fc receptor mediated stimulatory signaling pathway; positive regulation of cellular component organization; and regulation of MAPK cascade. Located in perinuclear region of cytoplasm and phagocytic vesicle membrane. Part of protein-containing complex. Biomarker of anti-basement membrane glomerulonephritis and mesangial proliferative glomerulonephritis. Orthologous to human RAPGEF1 (Rap guanine nucleotide exchange factor 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Lung (RPKM 102.4), Heart (RPKM 94.2) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Rapgef1 in Genome Data Viewer
    Location:
    3p12
    Exon count:
    28
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (33296211..33414119)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (12898349..13016234)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (8189594..8307077)

    Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene netrin G2 Neighboring gene mediator complex subunit 27 Neighboring gene uncharacterized LOC134486065 Neighboring gene uncharacterized LOC134486064 Neighboring gene golgin A2 like 1 Neighboring gene proline rich transmembrane protein 1B

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Identification of a novel splice variant of C3G which shows tissue-specific expression. Shivakrupa, et al. DNA Cell Biol, 1999 Sep. PMID 10492401
    2. Elevated expression of C3G protein in the peri-infarct myocardium of rats. Wang L, et al. Med Sci Monit Basic Res, 2013 Jan 1. PMID 23291598, Free PMC Article
    3. The Ras-mitogen-activated protein kinase pathway is critical for the activation of matrix metalloproteinase secretion and the invasiveness in v-crk-transformed 3Y1. Liu E, et al. Cancer Res, 2000 May 1. PMID 10811109
    4. C3G overexpression in glomerular epithelial cells during anti-GBM-induced glomerulonephritis. Rufanova VA, et al. Kidney Int, 2009 Jan. PMID 18784646, Free PMC Article
    5. Silencing of C3G increases cardiomyocyte survival inhibition and apoptosis via regulation of p-ERK1/2 and Bax. Yang D, et al. Clin Exp Pharmacol Physiol, 2019 Mar. PMID 30152875

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. silencing of C3G can increase cell survival inhibition and apoptosis in cardiomyocytes via regulation of p-ERK1/2 and Bax
      Title: Silencing of C3G increases cardiomyocyte survival inhibition and apoptosis via regulation of p-ERK1/2 and Bax.
    2. C3G acts as a pro-survival molecule in H9C2 cardiomyocytes by activation of phosphorylated-ERK1/2.
      Title: C3G overexpression promotes the survival of rat-derived H9C2 cardiomyocytes by p-ERK1/2.
    3. C3G protein expression exhibits in the myocardium of rats.
      Title: Elevated expression of C3G protein in the peri-infarct myocardium of rats.
    4. In mesangioproliferative glomerulonephritis (MPG), C3G is upregulated in glomerular mesangial cells (GMC). Increased C3G may contribute to the resolution stage of MPG by reducing GMC sensitivity to ET-1, modulating cellular motility, and actin dynamics.
      Title: Endothelin signaling via guanine exchange factor C3G in renal glomerular mesangial cells.
    5. C3G was overexpressed in accelerated anti-GBM antibody-induced glomerulonephritis and suggest that this modulates glomerular epithelial cell morphology and behavior
      Title: C3G overexpression in glomerular epithelial cells during anti-GBM-induced glomerulonephritis.
    6. Rap1 and its exchange factor C3G in mediating Fc gammaR-dependent phagocytosis.
      Title: Rap1 activation is required for Fc gamma receptor-dependent phagocytosis.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables guanyl-nucleotide exchange factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables guanyl-nucleotide exchange factor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of ERK1 and ERK2 cascade ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in Rap protein signal transduction ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in Ras protein signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of Ras protein signal transduction ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within activation of GTPase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within blood vessel development ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of canonical Wnt signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within cell-cell adhesion ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cellular response to cAMP ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cellular response to nerve growth factor stimulus ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in establishment of endothelial barrier ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within negative regulation of ERK1 and ERK2 cascade ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within negative regulation of Ras protein signal transduction ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within negative regulation of canonical Wnt signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within negative regulation of neural precursor cell proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in nerve growth factor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of neural precursor cell proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of phosphatidylinositol 3-kinase/protein kinase B signal transduction ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within platelet-derived growth factor receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of ERK1 and ERK2 cascade IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of Fc receptor mediated stimulatory signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of GTPase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of neuron projection development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of neuron projection development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of phagocytosis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of JNK cascade IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of cell junction assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in early endosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in perinuclear region of cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in phagocytic vesicle membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of protein-containing complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    rap guanine nucleotide exchange factor 1
    Names
    Rap guanine nucleotide exchange factor (GEF) 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001427397.1 → NP_001414326.1  rap guanine nucleotide exchange factor 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      Related
      ENSRNOP00000088594.1, ENSRNOT00000108449.2

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086021.1 Reference GRCr8

      Range
      33296211..33414119
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039106160.2 → XP_038962088.1  rap guanine nucleotide exchange factor 1 isoform X5

      UniProtKB/TrEMBL
      F1M8L9
      Conserved Domains (3) summary
      smart00147
      Location:1015 → 1244
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
      smart00229
      Location:867 → 1008
      RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
      PHA03247
      Location:217 → 338
      PHA03247; large tegument protein UL36; Provisional

    2. XM_063284486.1 → XP_063140556.1  rap guanine nucleotide exchange factor 1 isoform X8

      Related
      ENSRNOP00000102988.1, ENSRNOT00000161849.1

    3. XM_063284494.1 → XP_063140564.1  rap guanine nucleotide exchange factor 1 isoform X27

      Related
      ENSRNOP00000081072.1, ENSRNOT00000093970.2

    4. XM_039106164.2 → XP_038962092.1  rap guanine nucleotide exchange factor 1 isoform X12

      UniProtKB/TrEMBL
      F1M8L9
      Conserved Domains (3) summary
      smart00147
      Location:977 → 1206
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
      smart00229
      Location:829 → 970
      RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
      PHA03247
      Location:179 → 300
      PHA03247; large tegument protein UL36; Provisional

    5. XM_063284487.1 → XP_063140557.1  rap guanine nucleotide exchange factor 1 isoform X15

    6. XM_063284489.1 → XP_063140559.1  rap guanine nucleotide exchange factor 1 isoform X18

      Related
      ENSRNOP00000082703.2, ENSRNOT00000095571.2

    7. XM_063284488.1 → XP_063140558.1  rap guanine nucleotide exchange factor 1 isoform X16

    8. XM_063284495.1 → XP_063140565.1  rap guanine nucleotide exchange factor 1 isoform X29

    9. XM_039106157.2 → XP_038962085.1  rap guanine nucleotide exchange factor 1 isoform X1

      UniProtKB/TrEMBL
      F1M8L9
      Conserved Domains (3) summary
      smart00147
      Location:1028 → 1257
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
      smart00229
      Location:880 → 1021
      RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
      PHA03247
      Location:230 → 351
      PHA03247; large tegument protein UL36; Provisional

    10. XM_039106162.2 → XP_038962090.1  rap guanine nucleotide exchange factor 1 isoform X9

      UniProtKB/TrEMBL
      F1M8L9
      Conserved Domains (3) summary
      smart00147
      Location:996 → 1225
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
      smart00229
      Location:848 → 989
      RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
      PHA03247
      Location:230 → 802
      PHA03247; large tegument protein UL36; Provisional

    11. XM_039106167.2 → XP_038962095.1  rap guanine nucleotide exchange factor 1 isoform X19

      UniProtKB/TrEMBL
      A0A8I5ZQV4
      Conserved Domains (3) summary
      smart00147
      Location:910 → 1139
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
      smart00229
      Location:762 → 903
      RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
      PHA03247
      Location:230 → 351
      PHA03247; large tegument protein UL36; Provisional

    12. XM_039106158.2 → XP_038962086.1  rap guanine nucleotide exchange factor 1 isoform X2

      UniProtKB/TrEMBL
      F1M8L9
      Conserved Domains (3) summary
      smart00147
      Location:1027 → 1256
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
      smart00229
      Location:879 → 1020
      RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
      PHA03247
      Location:230 → 351
      PHA03247; large tegument protein UL36; Provisional

    13. XM_063284490.1 → XP_063140560.1  rap guanine nucleotide exchange factor 1 isoform X20

    14. XM_039106165.2 → XP_038962093.1  rap guanine nucleotide exchange factor 1 isoform X13

      UniProtKB/TrEMBL
      F1M8L9
      Conserved Domains (3) summary
      smart00147
      Location:976 → 1205
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
      smart00229
      Location:828 → 969
      RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
      PHA03247
      Location:230 → 351
      PHA03247; large tegument protein UL36; Provisional

    15. XM_063284491.1 → XP_063140561.1  rap guanine nucleotide exchange factor 1 isoform X22

    16. XM_039106168.2 → XP_038962096.1  rap guanine nucleotide exchange factor 1 isoform X23

      UniProtKB/TrEMBL
      A0A8I5ZRV1
      Conserved Domains (3) summary
      smart00147
      Location:858 → 1087
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
      smart00229
      Location:710 → 851
      RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
      PHA03247
      Location:230 → 351
      PHA03247; large tegument protein UL36; Provisional

    17. XM_039106159.2 → XP_038962087.1  rap guanine nucleotide exchange factor 1 isoform X4

      UniProtKB/TrEMBL
      F1M8L9
      Conserved Domains (3) summary
      smart00147
      Location:1019 → 1248
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
      smart00229
      Location:871 → 1012
      RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
      PHA03247
      Location:230 → 342
      PHA03247; large tegument protein UL36; Provisional

    18. XM_063284492.1 → XP_063140562.1  rap guanine nucleotide exchange factor 1 isoform X24

    19. XM_017592102.3 → XP_017447591.1  rap guanine nucleotide exchange factor 1 isoform X3

      UniProtKB/TrEMBL
      F1M8L9

    20. XM_008761683.4 → XP_008759905.2  rap guanine nucleotide exchange factor 1 isoform X6

      UniProtKB/TrEMBL
      F1M8L9

    21. XM_008761684.4 → XP_008759906.2  rap guanine nucleotide exchange factor 1 isoform X11

      UniProtKB/TrEMBL
      F1M8L9

    22. XM_039106161.2 → XP_038962089.1  rap guanine nucleotide exchange factor 1 isoform X7

      UniProtKB/TrEMBL
      F1M8L9
      Conserved Domains (3) summary
      smart00147
      Location:1012 → 1241
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
      smart00229
      Location:864 → 1005
      RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
      PRK14950
      Location:219 → 321
      PRK14950; DNA polymerase III subunits gamma and tau; Provisional

    23. XM_017592108.3 → XP_017447597.1  rap guanine nucleotide exchange factor 1 isoform X21

      UniProtKB/TrEMBL
      A0A8I5ZQV4

    24. XM_006233902.5 → XP_006233964.1  rap guanine nucleotide exchange factor 1 isoform X25

      See identical proteins and their annotated locations for XP_006233964.1

      UniProtKB/TrEMBL
      A0A8I5ZRV1
      Related
      ENSRNOP00000080887.2, ENSRNOT00000099738.2
      Conserved Domains (2) summary
      smart00147
      Location:843 → 1072
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
      smart00229
      Location:695 → 836
      RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif

    25. XM_039106163.2 → XP_038962091.1  rap guanine nucleotide exchange factor 1 isoform X10

      UniProtKB/TrEMBL
      F1M8L9
      Conserved Domains (3) summary
      smart00147
      Location:990 → 1219
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
      smart00229
      Location:842 → 983
      RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
      PHA03247
      Location:192 → 313
      PHA03247; large tegument protein UL36; Provisional

    26. XM_008761685.4 → XP_008759907.2  rap guanine nucleotide exchange factor 1 isoform X14

      UniProtKB/TrEMBL
      F1M8L9

    27. XM_008761686.4 → XP_008759908.2  rap guanine nucleotide exchange factor 1 isoform X17

      UniProtKB/TrEMBL
      F1M8L9

    28. XM_063284493.1 → XP_063140563.1  rap guanine nucleotide exchange factor 1 isoform X26

    29. XM_039106169.2 → XP_038962097.1  rap guanine nucleotide exchange factor 1 isoform X28

      UniProtKB/TrEMBL
      A0A8I5ZUL6
      Conserved Domains (4) summary
      PLN03209
      Location:191 → 429
      PLN03209; translocon at the inner envelope of chloroplast subunit 62; Provisional
      smart00147
      Location:805 → 1034
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
      smart00229
      Location:657 → 798
      RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
      PHA03247
      Location:192 → 298
      PHA03247; large tegument protein UL36; Provisional
    Nucleotide Protein Strain
    Heading Accession and Version

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