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    Pkn3 protein kinase N3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 296619, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Pkn3provided by RGD
    Official Full Name
    protein kinase N3provided by RGD
    Primary source
    RGD:1305921
    See related
    EnsemblRapid:ENSRNOG00000025892 AllianceGenome:RGD:1305921
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    LRRGT00147
    Summary
    Predicted to enable ATP binding activity; diacylglycerol-dependent serine/threonine kinase activity; and small GTPase binding activity. Predicted to be involved in epithelial cell migration. Orthologous to human PKN3 (protein kinase N3). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Thymus (RPKM 80.6), Spleen (RPKM 75.0) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Pkn3 in Genome Data Viewer
    Location:
    3p12
    Exon count:
    25
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (33747610..33761405)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (13350082..13363572)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (8628033..8656464)

    Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene spectrin, alpha, non-erythrocytic 1 Neighboring gene dynein 2 intermediate chain 2 Neighboring gene Set nuclear proto-oncogene Neighboring gene zinc finger DHHC-type palmitoyltransferase 12 Neighboring gene zyg-11 related, cell cycle regulator Neighboring gene TBC1 domain family, member 13

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Regulatory domain selectivity in the cell-type specific PKN-dependence of cell migration. Lachmann S, et al. PLoS One, 2011. PMID 21754995, Free PMC Article
    2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables calcium,diacylglycerol-dependent serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables diacylglycerol-dependent, calcium-independent serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables small GTPase binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in epithelial cell migration ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in nucleosome assembly IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    serine/threonine-protein kinase N3
    NP_001376165.1
    XP_006233834.1
    XP_006233836.1
    XP_008759862.1
    XP_038960668.1
    XP_038960670.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001389236.1 → NP_001376165.1  serine/threonine-protein kinase N3

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/TrEMBL
      A0A0G2JZ66, A0A8I5ZRC3, A6JTV0
      Related
      ENSRNOP00000070928.2, ENSRNOT00000077797.3
      Conserved Domains (5) summary
      cd11622
      Location:10 → 75
      HR1_PKN_1; First Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of Protein Kinase N
      PHA03378
      Location:457 → 545
      PHA03378; EBNA-3B; Provisional
      cl00087
      Location:91 → 164
      HR1; Protein kinase C-related kinase homology region 1 (HR1) domain that binds Rho family small GTPases
      cl14603
      Location:322 → 409
      C2; C2 domain
      cl21453
      Location:549 → 873
      PKc_like; Protein Kinases, catalytic domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086021.1 Reference GRCr8

      Range
      33747610..33761405
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039104742.2 → XP_038960670.1  serine/threonine-protein kinase N3 isoform X4

      Conserved Domains (4) summary
      cd11622
      Location:14 → 79
      HR1_PKN_1; First Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of Protein Kinase N
      PHA03378
      Location:461 → 560
      PHA03378; EBNA-3B; Provisional
      cl00087
      Location:95 → 168
      HR1; Protein kinase C-related kinase homology region 1 (HR1) domain that binds Rho family small GTPases
      cl14603
      Location:326 → 413
      C2; C2 domain

    2. XM_039104740.2 → XP_038960668.1  serine/threonine-protein kinase N3 isoform X3

      UniProtKB/TrEMBL
      A0A8I5ZRC3
      Related
      ENSRNOP00000043911.4, ENSRNOT00000050528.5
      Conserved Domains (5) summary
      cd11622
      Location:14 → 79
      HR1_PKN_1; First Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of Protein Kinase N
      PHA03378
      Location:413 → 501
      PHA03378; EBNA-3B; Provisional
      cl00087
      Location:95 → 168
      HR1; Protein kinase C-related kinase homology region 1 (HR1) domain that binds Rho family small GTPases
      cl14603
      Location:326 → 362
      C2; C2 domain
      cl21453
      Location:505 → 829
      PKc_like; Protein Kinases, catalytic domain

    3. XM_006233772.5 → XP_006233834.1  serine/threonine-protein kinase N3 isoform X1

      See identical proteins and their annotated locations for XP_006233834.1

      UniProtKB/TrEMBL
      A0A8I5ZRC3, A6JTU9
      Related
      ENSRNOP00000081137.2, ENSRNOT00000098135.2
      Conserved Domains (5) summary
      PTZ00263
      Location:549 → 873
      PTZ00263; protein kinase A catalytic subunit; Provisional
      cd11622
      Location:14 → 79
      HR1_PKN_1; First Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of Protein Kinase N
      cl00087
      Location:95 → 168
      HR1; Protein kinase C-related kinase homology region 1 (HR1) domain that binds Rho family small GTPases
      cl14603
      Location:326 → 413
      C2; C2 domain
      cl21453
      Location:553 → 877
      PKc_like; Protein Kinases, catalytic domain

    4. XM_006233774.5 → XP_006233836.1  serine/threonine-protein kinase N3 isoform X2

      See identical proteins and their annotated locations for XP_006233836.1

      UniProtKB/TrEMBL
      A0A8I5ZRC3
      Conserved Domains (5) summary
      PTZ00263
      Location:527 → 851
      PTZ00263; protein kinase A catalytic subunit; Provisional
      cd11622
      Location:2 → 57
      HR1_PKN_1; First Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of Protein Kinase N
      cl00087
      Location:73 → 146
      HR1; Protein kinase C-related kinase homology region 1 (HR1) domain that binds Rho family small GTPases
      cl14603
      Location:304 → 391
      C2; C2 domain
      cl21453
      Location:531 → 855
      PKc_like; Protein Kinases, catalytic domain

    5. XM_008761640.4 → XP_008759862.1  serine/threonine-protein kinase N3 isoform X2

      See identical proteins and their annotated locations for XP_008759862.1

      UniProtKB/TrEMBL
      A0A8I5ZRC3
      Conserved Domains (5) summary
      PTZ00263
      Location:527 → 851
      PTZ00263; protein kinase A catalytic subunit; Provisional
      cd11622
      Location:2 → 57
      HR1_PKN_1; First Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of Protein Kinase N
      cl00087
      Location:73 → 146
      HR1; Protein kinase C-related kinase homology region 1 (HR1) domain that binds Rho family small GTPases
      cl14603
      Location:304 → 391
      C2; C2 domain
      cl21453
      Location:531 → 855
      PKc_like; Protein Kinases, catalytic domain

    RNA

    1. XR_005501842.2 RNA Sequence

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001047861.1: Suppressed sequence

      Description
      NM_001047861.1: This RefSeq was removed because it is based on a transcript that represents a readthrough event with an upstream gene.
    Nucleotide Protein Strain
    Heading Accession and Version

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