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    EMC8-9 ER membrane protein complex subunit 8/9 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 37635, updated on 9-Dec-2024

    Summary

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    Official Symbol
    EMC8-9provided by FlyBase
    Official Full Name
    ER membrane protein complex subunit 8/9provided by FlyBase
    Primary source
    FLYBASE:FBgn0034791
    Locus tag
    Dmel_CG3501
    See related
    AllianceGenome:FB:FBgn0034791
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    BcDNA:SD01117; CG3501; Dmel\CG3501; emc8/9; EMC8/9
    Summary
    Contributes to membrane insertase activity. Involved in tail-anchored membrane protein insertion into ER membrane. Located in endomembrane system. Part of EMC complex. Is expressed in adult head and adult heart. Orthologous to human EMC8 (ER membrane protein complex subunit 8) and EMC9 (ER membrane protein complex subunit 9). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See EMC8-9 in Genome Data Viewer
    Location:
    59B4-59B4; 2-101 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (22881322..22882690, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (18768845..18770213, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene antisense RNA:CR45469 Neighboring gene Phosphatidylinositol 4-phosphate 5-kinase 59B Neighboring gene YME1 like ATPase Neighboring gene asrij Neighboring gene GDP-4-keto-6-deoxy-D-mannose 3,5-epimerase/4-reductase

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. ER complex proteins are required for rhodopsin biosynthesis and photoreceptor survival in Drosophila and mice. Xiong L, et al. Cell Death Differ, 2020 Feb. PMID 31263175, Free PMC Article
    2. dPob/EMC is essential for biosynthesis of rhodopsin and other multi-pass membrane proteins in Drosophila photoreceptors. Satoh T, et al. Elife, 2015 Feb 26. PMID 25715730, Free PMC Article
    3. Application of Fluorescent Proteins for Functional Dissection of the Drosophila Visual System. Smylla TK, et al. Int J Mol Sci, 2021 Aug 19. PMID 34445636, Free PMC Article
    4. EMC is required for biogenesis of Xport-A, an essential chaperone of Rhodopsin-1 and the TRP channel. Gaspar CJ, et al. EMBO Rep, 2022 Jan 5. PMID 34918864, Free PMC Article
    5. A microtubule interactome: complexes with roles in cell cycle and mitosis. Hughes JR, et al. PLoS Biol, 2008 Apr 22. PMID 18433294, Free PMC Article

    See all (37) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    contributes_to membrane insertase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    contributes_to membrane insertase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in tail-anchored membrane protein insertion into ER membrane IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of EMC complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of EMC complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of EMC complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    located_in endomembrane system HDA PubMed 

    General protein information

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    Preferred Names
    ER membrane protein complex subunit 8/9
    Names
    CG3501-PA
    EMC8-9-PA
    ER membrane protein complex 8-9
    endoplasmic reticulum membrane protein complex 8/9
    subunit 8/9 of EMC

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      22881322..22882690 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_137887.4 → NP_611731.1  ER membrane protein complex subunit 8/9 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_611731.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9W1Y1
      UniProtKB/TrEMBL
      Q86R94
      Related
      FBpp0071818
      Conserved Domains (1) summary
      pfam03665
      Location:3 → 188
      UPF0172; uncharacterized protein family (UPF0172)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q86R94 Q86R94
    Q9W1Y1.1 Q9W1Y1

    Gene LinkOut

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