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    wrd well-rounded [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 42169, updated on 9-Dec-2024

    Summary

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    Official Symbol
    wrdprovided by FlyBase
    Official Full Name
    well-roundedprovided by FlyBase
    Primary source
    FLYBASE:FBgn0042693
    Locus tag
    Dmel_CG7913
    See related
    AllianceGenome:FB:FBgn0042693
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    anon-WO0118547.420; B'; B'/PR61; B56-1; BcDNA:GM05554; CG 7913; CG7901; CG7913; dB56-1; Dmel\CG7913; dPP2A; dPP2A-B56-1; i234; PP2A; PP2A B'; PP2A-B; pp2A-B'; PP2A-B'; PP2A[B'-1]; Wrd
    Summary
    Predicted to enable protein phosphatase activator activity. Involved in several processes, including negative regulation of signal transduction; neuromuscular synaptic transmission; and synaptonemal complex disassembly. Predicted to be part of protein phosphatase type 2A complex. Predicted to be active in cytosol and nucleus. Is expressed in embryonic/larval neuromuscular junction; larval central nervous system; and organism. Human ortholog(s) of this gene implicated in autosomal dominant intellectual developmental disorder 35. Orthologous to several human genes including PPP2R5D (protein phosphatase 2 regulatory subunit B'delta). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See wrd in Genome Data Viewer
    Location:
    90F4-90F5; 3-62 cM
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (18167757..18180049)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (13993479..14005771)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene cap binding protein 20 Neighboring gene uncharacterized protein Neighboring gene Peroxiredoxin 5 Neighboring gene cadmus Neighboring gene uncharacterized protein Neighboring gene Actin-related protein 5 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Phosphorylation status of the SCR homeodomain determines its functional activity: essential role for protein phosphatase 2A,B'. Berry M, et al. EMBO J, 2000 Jun 15. PMID 10856239, Free PMC Article
    2. Drosophila protein phosphatases 2A B' Wdb and Wrd regulate meiotic centromere localization and function of the MEI-S332 Shugoshin. Pinto BS, et al. Proc Natl Acad Sci U S A, 2017 Dec 5. PMID 29158400, Free PMC Article
    3. PP2A regulatory subunit PP2A-B' counteracts S6K phosphorylation. Hahn K, et al. Cell Metab, 2010 May 5. PMID 20444422
    4. Identification of PP2A and S6 Kinase as Modifiers of Leucine-Rich Repeat Kinase-Induced Neurotoxicity. Sim JPL, et al. Neuromolecular Med, 2020 Jun. PMID 31664682, Free PMC Article
    5. Par-1 and PP2A: Yin-Yang of Bazooka localization. Choi KW, et al. Fly (Austin), 2007 Jul-Aug. PMID 18820442

    See all (100) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. SCF-Fbxo42 promotes synaptonemal complex assembly by downregulating PP2A-B56.
      Title: SCF-Fbxo42 promotes synaptonemal complex assembly by downregulating PP2A-B56.
    2. Wdb and Wrd contribute to MEI-S332's ability to ensure accurate segregation of sister chromatids but in centromere localization, they do not act solely downstream of MEI-S332.
      Title: Drosophila protein phosphatases 2A B' Wdb and Wrd regulate meiotic centromere localization and function of the MEI-S332 Shugoshin.
    3. The metabolic defects of cycG mutant animals are abrogated by a concomitant loss of Wdb, CycG presumably influences Akt1 activity at the PP2A nexus; Well rounded (Wrd), another B' subunit of PP2A in Drosophila, binds CycG similar to Wdb, and that its loss ameliorates some, but not all, of the metabolic defects of cycG mutants.
      Title: A triangular connection between Cyclin G, PP2A and Akt1 in the regulation of growth and metabolism in Drosophila.
    4. a PP2A holoenzyme containing the PP2A-B' regulatory subunit has no role in the dephosphorylation and activation of Sex comb reduced
      Title: Non-requirement of a regulatory subunit of Protein Phosphatase 2A, PP2A-B', for activation of Sex comb reduced activity in Drosophila melanogaster.
    5. Study suggests that in photoreceptors, Par-1 blocks the localization of Baz to AJ whereas protein phosphatase 2A (PP2A) promotes Baz localization by antagonizing the Par-1 effects.
      Title: Par-1 and PP2A: Yin-Yang of Bazooka localization.
    6. The results reveal that the B56-containing isoform of PP2A functions within multiple signaling pathways, including those that regulate expression of reaper and the response to oxidative stress, thus promoting cell survival in Drosophila.
      Title: A functional genomics analysis of the B56 isoforms of Drosophila protein phosphatase 2A.
    7. antagonism between PP2A and Par-1 plays a key role in Baz localization at adherens junctions in photoreceptor morphogenesis
      Title: Antagonistic functions of Par-1 kinase and protein phosphatase 2A are required for localization of Bazooka and photoreceptor morphogenesis in Drosophila.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables protein phosphatase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein phosphatase regulator activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein phosphatase regulator activity NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in meiotic sister chromatid cohesion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of TORC1 signaling IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of apoptotic process NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in negative regulation of hippo signaling IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of insulin receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in neuromuscular junction development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in neuromuscular synaptic transmission IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of macroautophagy IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    NOT involved_in sex comb development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in synaptic vesicle localization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in synaptonemal complex disassembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in triglyceride homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of protein phosphatase type 2A complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of protein phosphatase type 2A complex IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    well-rounded
    Names
    CG7913-PA
    CG7913-PB
    CG7913-PC
    CG7913-PD
    CG7913-PE
    CG7913-PI
    CG7913-PJ
    CG7913-PK
    CG7913-PL
    CG7913-PM
    CG7913-PN
    CG7913-PO
    CG7913-PP
    CG7913-PQ
    PP2A B' regulatory subunit
    PP2A B' subunit
    PP2A-B'
    protein phosphatase 2A
    protein phosphatase 2A B'
    protein phosphatase 2A regulatory B subunit
    protein phosphatase 2A-B'
    regulatory B' subunit of PP2A
    well rounded
    wrd-PA
    wrd-PB
    wrd-PC
    wrd-PD
    wrd-PE
    wrd-PI
    wrd-PJ
    wrd-PK
    wrd-PL
    wrd-PM
    wrd-PN
    wrd-PO
    wrd-PP
    wrd-PQ

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      18167757..18180049
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001144598.3 → NP_001138070.1  well-rounded, isoform K [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001138070.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      D2NUL2, Q5BIJ2
      Conserved Domains (2) summary
      PLN00122
      Location:499 → 598
      PLN00122; serine/threonine protein phosphatase 2A; Provisional
      pfam01603
      Location:193 → 594
      B56; Protein phosphatase 2A regulatory B subunit (B56 family)

    2. NM_001144599.2 → NP_001138071.1  well-rounded, isoform J [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001138071.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      B7Z0L6
      Conserved Domains (2) summary
      PLN00122
      Location:499 → 598
      PLN00122; serine/threonine protein phosphatase 2A; Provisional
      pfam01603
      Location:193 → 594
      B56; Protein phosphatase 2A regulatory B subunit (B56 family)

    3. NM_142424.3 → NP_650681.2  well-rounded, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_650681.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      C6SV32, Q0KI58
      Related
      FBpp0082975
      Conserved Domains (2) summary
      PLN00122
      Location:499 → 598
      PLN00122; serine/threonine protein phosphatase 2A; Provisional
      pfam01603
      Location:193 → 594
      B56; Protein phosphatase 2A regulatory B subunit (B56 family)

    4. NM_169787.2 → NP_732293.1  well-rounded, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_732293.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      C6SV32, Q0KI58
      Related
      FBpp0082974
      Conserved Domains (2) summary
      PLN00122
      Location:499 → 598
      PLN00122; serine/threonine protein phosphatase 2A; Provisional
      pfam01603
      Location:193 → 594
      B56; Protein phosphatase 2A regulatory B subunit (B56 family)

    5. NM_001144600.2 → NP_001138072.1  well-rounded, isoform I [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001138072.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      B7Z0L7
      Conserved Domains (2) summary
      PLN00122
      Location:267 → 366
      PLN00122; serine/threonine protein phosphatase 2A; Provisional
      pfam01603
      Location:1 → 362
      B56; Protein phosphatase 2A regulatory B subunit (B56 family)

    6. NM_001275766.1 → NP_001262695.1  well-rounded, isoform Q [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001262695.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4KHB9
      Conserved Domains (2) summary
      PLN00122
      Location:512 → 611
      PLN00122; serine/threonine protein phosphatase 2A; Provisional
      pfam01603
      Location:206 → 607
      B56; Protein phosphatase 2A regulatory B subunit (B56 family)

    7. NM_001275765.1 → NP_001262694.1  well-rounded, isoform P [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001262694.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4KHP7, Q9NFM7
      Conserved Domains (2) summary
      PLN00122
      Location:512 → 611
      PLN00122; serine/threonine protein phosphatase 2A; Provisional
      pfam01603
      Location:206 → 607
      B56; Protein phosphatase 2A regulatory B subunit (B56 family)

    8. NM_001260247.1 → NP_001247176.1  well-rounded, isoform L [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001247176.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      C6SV32, Q0KI58
      Conserved Domains (2) summary
      PLN00122
      Location:499 → 598
      PLN00122; serine/threonine protein phosphatase 2A; Provisional
      pfam01603
      Location:193 → 594
      B56; Protein phosphatase 2A regulatory B subunit (B56 family)

    9. NM_001260248.1 → NP_001247177.1  well-rounded, isoform M [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001247177.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      C6SV32, Q0KI58
      Conserved Domains (2) summary
      PLN00122
      Location:499 → 598
      PLN00122; serine/threonine protein phosphatase 2A; Provisional
      pfam01603
      Location:193 → 594
      B56; Protein phosphatase 2A regulatory B subunit (B56 family)

    10. NM_001260250.1 → NP_001247179.1  well-rounded, isoform O [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001247179.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      D2NUL2, Q5BIJ2
      Conserved Domains (2) summary
      PLN00122
      Location:499 → 598
      PLN00122; serine/threonine protein phosphatase 2A; Provisional
      pfam01603
      Location:193 → 594
      B56; Protein phosphatase 2A regulatory B subunit (B56 family)

    11. NM_001260249.1 → NP_001247178.1  well-rounded, isoform N [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001247178.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      C6SV32, Q0KI58
      Conserved Domains (2) summary
      PLN00122
      Location:499 → 598
      PLN00122; serine/threonine protein phosphatase 2A; Provisional
      pfam01603
      Location:193 → 594
      B56; Protein phosphatase 2A regulatory B subunit (B56 family)

    12. NM_169788.1 → NP_732294.1  well-rounded, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_732294.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      C6SV32, Q8IN90
      Related
      FBpp0082976, FBtr0083554
      Conserved Domains (2) summary
      PLN00122
      Location:383 → 482
      PLN00122; serine/threonine protein phosphatase 2A; Provisional
      pfam01603
      Location:77 → 478
      B56; Protein phosphatase 2A regulatory B subunit (B56 family)

    13. NM_169789.2 → NP_732295.1  well-rounded, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_732295.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8IN89
      Related
      FBpp0082978
      Conserved Domains (2) summary
      PLN00122
      Location:780 → 879
      PLN00122; serine/threonine protein phosphatase 2A; Provisional
      pfam01603
      Location:474 → 875
      B56; Protein phosphatase 2A regulatory B subunit (B56 family)

    14. NM_169790.1 → NP_732296.1  well-rounded, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_732296.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VEC6
      Related
      FBpp0082977, FBtr0083555
      Conserved Domains (2) summary
      PLN00122
      Location:780 → 879
      PLN00122; serine/threonine protein phosphatase 2A; Provisional
      pfam01603
      Location:474 → 875
      B56; Protein phosphatase 2A regulatory B subunit (B56 family)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4KHB9 A0A0B4KHB9
    A0A0B4KHP7 A0A0B4KHP7
    B7Z0L6 B7Z0L6
    B7Z0L7 B7Z0L7
    Q0KI58 Q0KI58
    Q5BIJ2 Q5BIJ2
    Q8IN89 Q8IN89
    Q8IN90 Q8IN90
    Q95S91 Q95S91
    Q9NFM7 Q9NFM7
    Q9VEC6 Q9VEC6

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