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    GstE9 Glutathione S transferase E9 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 246581, updated on 9-Dec-2024

    Summary

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    Official Symbol
    GstE9provided by FlyBase
    Official Full Name
    Glutathione S transferase E9provided by FlyBase
    Primary source
    FLYBASE:FBgn0063491
    Locus tag
    Dmel_CG17534
    See related
    AllianceGenome:FB:FBgn0063491
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG17534; CT38753; Dmel\CG17534; DmGSTE9; E9; Gst3-1; GST3-1; gste9; GSTE9
    Summary
    Enables glutathione transferase activity. Involved in glutathione metabolic process. Predicted to be located in cytoplasm. Is expressed in adult head. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See GstE9 in Genome Data Viewer
    Location:
    55C8-55C8; 2-85 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (18409048..18409835)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (14296553..14297340)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene Glutathione S transferase E7 Neighboring gene Glutathione S transferase E8 Neighboring gene immune deficiency Neighboring gene Dodeca-satellite-binding protein 1 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. High efficiency of a double-screening method on single P-element insertion lines to identify quantitative trait mutants in Drosophila melanogaster. Martin F, et al. Genetica, 2006 Sep-Nov. PMID 17028964
    2. Small Maf functions in the maintenance of germline stem cells in the Drosophila testis. Tan SWS, et al. Redox Biol, 2018 May. PMID 29245136, Free PMC Article
    3. Epsilon glutathione transferases possess a unique class-conserved subunit interface motif that directly interacts with glutathione in the active site. Wongsantichon J, et al. Biosci Rep, 2015 Oct 20. PMID 26487708, Free PMC Article
    4. Identification of novel modifiers of Aβ toxicity by transcriptomic analysis in the fruitfly. Favrin G, et al. Sci Rep, 2013 Dec 16. PMID 24336499, Free PMC Article
    5. The genetic architecture of methotrexate toxicity is similar in Drosophila melanogaster and humans. Kislukhin G, et al. G3 (Bethesda), 2013 Aug 7. PMID 23733889, Free PMC Article

    See all (49) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables glutathione transferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables glutathione transferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in glutathione metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in glutathione metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    glutathione S transferase E9
    Names
    CG17534-PA
    GstE9-PA
    glutathion S-transferase
    NP_725784.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      18409048..18409835
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_166279.3 → NP_725784.1  glutathione S transferase E9 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_725784.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      D8FT08, Q7K8X7
      Related
      FBpp0085858
      Conserved Domains (3) summary
      cd03177
      Location:92 → 209
      GST_C_Delta_Epsilon; C-terminal, alpha helical domain of Class Delta and Epsilon Glutathione S-transferases
      COG0625
      Location:4 → 201
      GstA; Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]
      cd03045
      Location:4 → 76
      GST_N_Delta_Epsilon; GST_N family, Class Delta and Epsilon subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7K8X7 Q7K8X7

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