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    Takl2 Tak1-like 2 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 42692, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Takl2provided by FlyBase
    Official Full Name
    Tak1-like 2provided by FlyBase
    Primary source
    FLYBASE:FBgn0039015
    Locus tag
    Dmel_CG4803
    See related
    AllianceGenome:FB:FBgn0039015
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG4803; Dmel\CG4803; TAK; takl2
    Summary
    Predicted to enable protein kinase activity. Predicted to be involved in signal transduction. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Takl2 in Genome Data Viewer
    Location:
    94C4-94C4; 3-76 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (22732356..22733851, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (18558078..18559573, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Iron regulatory protein 1A Neighboring gene antisense RNA:CR45648 Neighboring gene ring finger protein 220 Neighboring gene uncharacterized protein Neighboring gene Dicer-1 Neighboring gene uncharacterized protein Neighboring gene vreteno

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Renal Purge of Hemolymphatic Lipids Prevents the Accumulation of ROS-Induced Inflammatory Oxidized Lipids and Protects Drosophila from Tissue Damage. Li X, et al. Immunity, 2020 Feb 18. PMID 32075729
    2. Drosophila Cancer Models Identify Functional Differences between Ret Fusions. Levinson S, et al. Cell Rep, 2016 Sep 13. PMID 27626672, Free PMC Article
    3. A targeted UAS-RNAi screen in Drosophila larvae identifies wound closure genes regulating distinct cellular processes. Lesch C, et al. Genetics, 2010 Nov. PMID 20813879, Free PMC Article
    4. JNK signaling is needed to tolerate chromosomal instability. Wong HW, et al. Cell Cycle, 2014. PMID 24335260, Free PMC Article
    5. Evolution of protein kinase signaling from yeast to man. Manning G, et al. Trends Biochem Sci, 2002 Oct. PMID 12368087

    See all (27) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables MAP kinase kinase kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables magnesium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    Tak1-like 2
    Names
    CG4803-PB
    Takl2-PB
    NP_651090.2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      22732356..22733851 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_142833.2 → NP_651090.2  Tak1-like 2 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_651090.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      C1C3D4, Q9VCV0
      Conserved Domains (2) summary
      smart00220
      Location:14 → 258
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cl21453
      Location:19 → 268
      PKc_like; Protein Kinases, catalytic domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VCV0 Q9VCV0

    Gene LinkOut

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