U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Brd Bearded [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 39620, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    Brdprovided by FlyBase
    Official Full Name
    Beardedprovided by FlyBase
    Primary source
    FLYBASE:FBgn0000216
    Locus tag
    Dmel_CG3096
    See related
    AllianceGenome:FB:FBgn0000216
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    bearded; brd; Brd-C; CG3096; DmelCG3096; Dmel\CG3096
    Summary
    Enables ubiquitin protein ligase binding activity. Involved in cell fate specification. Is expressed in several structures, including eye disc morphogenetic furrow; hindgut proper primordium; imaginal disc; proneural cluster; and wing. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See Brd in Genome Data Viewer
    Location:
    71A4-71A4; 3-42 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (14972667..14973198)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (14965767..14966298)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR45978 Neighboring gene Twin of m4 Neighboring gene long non-coding RNA:marge Neighboring gene ocho

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. minidiscs encodes a putative amino acid transporter subunit required non-autonomously for imaginal cell proliferation. Martin JF, et al. Mech Dev, 2000 Apr. PMID 10727855
    2. Drop out: a third chromosome maternal-effect locus required for formation of the Drosophila cellular blastoderm. Galewsky S, et al. Mol Reprod Dev, 1992 Aug. PMID 1497881
    3. Hairless is required for the development of adult sensory organ precursor cells in Drosophila. Bang AG, et al. Development, 1991 Jan. PMID 2015800
    4. Induction of neuron-specific glycosylation by Tollo/Toll-8, a Drosophila Toll-like receptor expressed in non-neural cells. Seppo A, et al. Development, 2003 Apr. PMID 12588858
    5. The Bearded box, a novel 3' UTR sequence motif, mediates negative post-transcriptional regulation of Bearded and Enhancer of split Complex gene expression. Lai EC, et al. Development, 1997 Dec. PMID 9428421

    See all (94) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Data show that Neuralized (Neur) regulates collective apical constriction and furrow formation, and the Bearded (Brd) proteins antagonize maternal Neur and lower medial-apical contractility in the ectoderm.
      Title: Spatial regulation of contractility by Neuralized and Bearded during furrow invagination in Drosophila.
    2. inhibition and activation of Notch signaling rely on a conserved Neuralized-binding motif in Bearded proteins and the Notch ligand Delta
      Title: Both inhibition and activation of Notch signaling rely on a conserved Neuralized-binding motif in Bearded proteins and the Notch ligand Delta.
    3. inhibition of Neur by Brd proteins is important for precise spatial regulation of Dl signaling
      Title: Bearded family members inhibit Neuralized-mediated endocytosis and signaling activity of Delta in Drosophila.
    Submit: New GeneRIF Correction

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ubiquitin protein ligase binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cell fate specification IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of Notch signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 

    General protein information

    Go to the top of the page Help
    Preferred Names
    bearded
    Names
    Brd-PA
    CG3096-PA

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      14972667..14973198
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_057541.5 → NP_476889.1  bearded [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_476889.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      O16528, Q5G1W4
      Related
      FBpp0075374
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O16528 O16528
    Q5G1W4 Q5G1W4
    Q5G1X9 Q5G1X9
    Q5G1Y7 Q5G1Y7

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Molecular Biology Databases
    Research Materials
    Tools