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    FoxL1 Forkhead box L1 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 38471, updated on 9-Dec-2024

    Summary

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    Official Symbol
    FoxL1provided by FlyBase
    Official Full Name
    Forkhead box L1provided by FlyBase
    Primary source
    FLYBASE:FBgn0004895
    Locus tag
    Dmel_CG1132
    See related
    AllianceGenome:FB:FBgn0004895
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG1132; Dmel\CG1132; Dmfd2; fd2; FD2; fd64A; Fd64A; foxL1
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in positive regulation of gene expression. Located in nucleus. Is expressed in several structures, including embryonic hindgut; embryonic small intestine; embryonic thoracic segment; larval muscle cell; and mesoderm. Human ortholog(s) of this gene implicated in otosclerosis 11. Orthologous to human FOXL1 (forkhead box L1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See FoxL1 in Genome Data Viewer
    Location:
    64A4-64A4; 3-10 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (4018878..4021279)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (4018878..4021279)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene scratch Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Mitochondrial E3 ubiquitin protein ligase 1 Neighboring gene Gustatory receptor 64a

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. An ancient Fox gene cluster in bilaterian animals. Mazet F, et al. Curr Biol, 2006 May 9. PMID 16682334
    2. Drosophila FoxL1 non-autonomously coordinates organ placement during embryonic development. Hanlon CD, et al. Dev Biol, 2016 Nov 15. PMID 27618755, Free PMC Article
    3. Developmentally regulated Drosophila gene family encoding the fork head domain. Häcker U, et al. Proc Natl Acad Sci U S A, 1992 Sep 15. PMID 1356269, Free PMC Article
    4. Five years on the wings of fork head. Kaufmann E, et al. Mech Dev, 1996 Jun. PMID 8817449
    5. Co-crystal structure of the HNF-3/fork head DNA-recognition motif resembles histone H5. Clark KL, et al. Nature, 1993 Jul 29. PMID 8332212

    See all (47) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables sequence-specific DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in anatomical structure morphogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cell differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    forkhead box L1
    Names
    CG1132-PA
    CG1132-PB
    FoxL1-PA
    FoxL1-PB
    forkhead domain 64A

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      4018878..4021279
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001259680.2 → NP_001246609.1  forkhead box L1, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001246609.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q02360, Q9VZK0
      UniProtKB/TrEMBL
      D3PFH7
      Conserved Domains (1) summary
      smart00339
      Location:91 → 185
      FH; FORKHEAD

    2. NM_079188.3 → NP_523912.1  forkhead box L1, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_523912.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q02360, Q9VZK0
      UniProtKB/TrEMBL
      D3PFH7
      Related
      FBpp0073048
      Conserved Domains (1) summary
      smart00339
      Location:91 → 185
      FH; FORKHEAD
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    D3PFH7 D3PFH7
    Q02360.2 Q02360

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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