eff effete [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: effprovided by FlyBase
Official Full Name: effeteprovided by FlyBase
Primary source: FLYBASE:FBgn0011217
Locus tag: Dmel_CG7425
See related: AllianceGenome:FB:FBgn0011217
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: 3527; 6535; anon-WO0118547.343; CG7425; Dmel\CG7425; E(Pc)88D; E2; Eff; EFF; fs(3)01295; l(3)01462; l(3)j2C8; l(3)s1782; mei68; ms(3)01295; ms(3)1; ms(3)3; ms(3)88D; ms(3)neo2; ms(3)ry1; ms(3)ry3; SS3-3; Ubc-D1; UBC4; Ubc5; UbcD; UBCD-1; ubcD1; UbcD1; UBCD1; UbcH5
Summary: Enables ubiquitin conjugating enzyme activity and ubiquitin protein ligase binding activity. Involved in several processes, including anaphase-promoting complex-dependent catabolic process; female germ-line stem cell asymmetric division; and neuron differentiation. Predicted to be active in nucleus. Is expressed in adult head; embryonic/larval tracheal section; imaginal disc; larval brain; and organism. Orthologous to several human genes including UBE2D2 (ubiquitin conjugating enzyme E2 D2) and UBE2D3 (ubiquitin conjugating enzyme E2 D3). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 88D2-88D2; 3-56 cM

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3R	NT_033777.3 (14732414..14741319, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3R	NT_033777.2 (10558136..10567041, complement)

Chromosome 3R - NT_033777.3 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

UbcD1 regulates Hedgehog signaling by directly modulating Ci ubiquitination and processing.
Title: UbcD1 regulates Hedgehog signaling by directly modulating Ci ubiquitination and processing.
eff regulates both telomere position effect and position effect variegation.
Title: Effete, a Drosophila chromatin-associated ubiquitin-conjugating enzyme that affects telomeric and heterochromatic position effect variegation.
Effete/APC-mediated degradation of Cyclin A is essential for the maintenance of germline stem cells
Title: Effete-mediated degradation of Cyclin A is essential for the maintenance of germline stem cells in Drosophila.
Regulation of Drosophila IAP1 degradation and apoptosis by reaper and ubcD1.
Title: Regulation of Drosophila IAP1 degradation and apoptosis by reaper and ubcD1.
the UbcD1 substrate(s) binds chromosomal termini in a sequence-independent manner
Title: The role of HeT-A and TART retrotransposons in Drosophila telomere capping.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Dm0686 (e-PCR)
- UniSTS:18242

Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables ubiquitin conjugating enzyme activity	IBA Inferred from Biological aspect of Ancestor more info
enables ubiquitin conjugating enzyme activity	IDA Inferred from Direct Assay more info	PubMed
enables ubiquitin conjugating enzyme activity	IGI Inferred from Genetic Interaction more info	PubMed
enables ubiquitin protein ligase binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in anaphase-promoting complex-dependent catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in chromosome organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in compound eye morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in compound eye photoreceptor cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in female germ-line stem cell asymmetric division	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in germ-line stem cell population maintenance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in male meiotic nuclear division	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mitotic cell cycle	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of smoothened signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neuron remodeling	IDA Inferred from Direct Assay more info	PubMed
involved_in peptidoglycan recognition protein signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein linear polyubiquitination	IDA Inferred from Direct Assay more info	PubMed
involved_in protein polyubiquitination	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein polyubiquitination	IDA Inferred from Direct Assay more info	PubMed
involved_in protein polyubiquitination	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein ubiquitination	IDA Inferred from Direct Assay more info	PubMed
involved_in protein ubiquitination	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in regulation of R7 cell differentiation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of protein stability	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in ubiquitin-dependent protein catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in ubiquitin-dependent protein catabolic process	IGI Inferred from Genetic Interaction more info	PubMed
involved_in ubiquitin-dependent protein catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: effete

Names: CG7425-PA; CG7425-PB; CG7425-PC; eff-PA; eff-PB; eff-PC; effette; meiotic 68; suppressor of GMR-sina 3-3; ubiquitin conjugating enzyme 1

NP_001262578.1

EC 2.3.2.23

NP_001262579.1

EC 2.3.2.23

NP_731941.1

EC 2.3.2.23

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033777.3 Reference assembly

Range

14732414..14741319 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001275650.1 → NP_001262579.1 effete, isoform C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001262579.1

Status: REVIEWED

UniProtKB/Swiss-Prot

P25867, Q9VFG6

UniProtKB/TrEMBL

A0A0B4KHJ1

Conserved Domains (1) summary

cl00154
Location:1 → 146

UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...
NM_169601.2 → NP_731941.1 effete, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_731941.1

Status: REVIEWED

UniProtKB/Swiss-Prot

P25867, Q9VFG6

UniProtKB/TrEMBL

A0A0B4KHJ1

Related

FBpp0082477

Conserved Domains (1) summary

cl00154
Location:1 → 146

UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...
NM_001275649.1 → NP_001262578.1 effete, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001262578.1

Status: REVIEWED

UniProtKB/Swiss-Prot

P25867, Q9VFG6

UniProtKB/TrEMBL

A0A0B4KHJ1

Conserved Domains (1) summary

cl00154
Location:1 → 146

UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...