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    iotaTry iotaTrypsin [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 36223, updated on 9-Dec-2024

    Summary

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    Official Symbol
    iotaTryprovided by FlyBase
    Official Full Name
    iotaTrypsinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0015001
    Locus tag
    Dmel_CG7754
    See related
    AllianceGenome:FB:FBgn0015001
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    143775_at; CG7754; Dmel\CG7754; IotaTry; SP129
    Summary
    Enables serine hydrolase activity. Predicted to be involved in proteolysis. Orthologous to human PRSS36 (serine protease 36) and PRSS53 (serine protease 53). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See iotaTry in Genome Data Viewer
    Location:
    47F5-47F5; 2-64 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (11356720..11357537)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (7244225..7245042)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene deltaTrypsin Neighboring gene uncharacterized protein Neighboring gene transfer RNA:Selenocysteine-TCA 1-1 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. intersex, a gene required for female sexual development in Drosophila, is expressed in both sexes and functions together with doublesex to regulate terminal differentiation. Garrett-Engele CM, et al. Development, 2002 Oct. PMID 12361959
    2. Study on the material basis and mechanism of Hemerocallis citrina Baroni on sleep-improvement using Drosophila activity monitoring, metabolomic, targeted screening and transcriptomic. Liang Y, et al. Food Res Int, 2023 Oct. PMID 37689837
    3. Direct protein-protein interaction network for insecticide resistance based on subcellular localization analysis in Drosophila melanogaster. Zhang G, et al. J Environ Sci Health B, 2020. PMID 32567974
    4. Concerted evolution within a trypsin gene cluster in Drosophila. Wang S, et al. Mol Biol Evol, 1999 Sep. PMID 10486967
    5. A novel interplay between the ubiquitin–proteasome system and serine proteases during Drosophila development. Lipinszki Z, et al. Biochem J, 2013 Sep 15. PMID 23805892

    See all (36) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables serine hydrolase activity HDA PubMed 
    enables serine-type endopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables serine-type endopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables serine-type endopeptidase activity ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in proteolysis ISM
    Inferred from Sequence Model
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    iotaTrypsin
    Names
    CG7754-PA
    iotaTry-PA
    trypsin iota
    NP_523695.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      11356720..11357537
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_078971.4 → NP_523695.1  iotaTrypsin [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_523695.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P52905, Q540Z6, Q9V5Y6
      Related
      FBpp0087226
      Conserved Domains (2) summary
      smart00020
      Location:27 → 245
      Tryp_SPc; Trypsin-like serine protease
      cd00190
      Location:28 → 247
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P52905.1 P52905

    Gene LinkOut

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