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    nAChRalpha3 nicotinic Acetylcholine Receptor alpha3 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 31767, updated on 9-Dec-2024

    Summary

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    Official Symbol
    nAChRalpha3provided by FlyBase
    Official Full Name
    nicotinic Acetylcholine Receptor alpha3provided by FlyBase
    Primary source
    FLYBASE:FBgn0015519
    Locus tag
    Dmel_CG2302
    See related
    AllianceGenome:FB:FBgn0015519
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Acr7E; alpha3; CG2302; Da3; Dalpha3; Dalpha3 nAChR; Dmel\CG2302; D[a3]; lincRNA.965; nAChR; nAchRalpha3; nAcRalpha-7E; nACRalpha-7E; nAcRe; nicra3
    Summary
    Contributes to acetylcholine receptor activity and acetylcholine-gated monoatomic cation-selective channel activity. Involved in monoatomic cation transport. Part of acetylcholine-gated channel complex. Is expressed in adult head and lamina monopolar neuron L2. Human ortholog(s) of this gene implicated in several diseases, including alcohol dependence; autosomal dominant nocturnal frontal lobe epilepsy (multiple); congenital myasthenic syndrome (multiple); gastrointestinal system cancer (multiple); and lung cancer (multiple). Orthologous to several human genes including CHRNA3 (cholinergic receptor nicotinic alpha 3 subunit) and CHRNA6 (cholinergic receptor nicotinic alpha 6 subunit). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See nAChRalpha3 in Genome Data Viewer
    Location:
    7E1-7E4; 1-23 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (8276200..8367169, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (8170233..8261202, complement)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Companion of reaper Neighboring gene long non-coding RNA:CR43695 Neighboring gene uncharacterized protein Neighboring gene pseudo

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Neuronal nicotinic acetylcholine receptors of Drosophila melanogaster: the alpha-subunit dalpha3 and the beta-type subunit ARD co-assemble within the same receptor complex. Chamaon K, et al. FEBS Lett, 2000 Oct 6. PMID 11024458
    2. The spread of resistance to imidacloprid is restricted by thermotolerance in natural populations of Drosophila melanogaster. Fournier-Level A, et al. Nat Ecol Evol, 2019 Apr. PMID 30886368
    3. Structural Analysis and Deletion Mutagenesis Define Regions of QUIVER/SLEEPLESS that Are Responsible for Interactions with Shaker-Type Potassium Channels and Nicotinic Acetylcholine Receptors. Wu M, et al. PLoS One, 2016. PMID 26828958, Free PMC Article
    4. Calcium-stores mediate adaptation in axon terminals of olfactory receptor neurons in Drosophila. Murmu MS, et al. BMC Neurosci, 2011 Oct 24. PMID 22024464, Free PMC Article
    5. How complex is the nicotinic receptor system of insects? Gundelfinger ED. Trends Neurosci, 1992 Jun. PMID 1378663

    See all (92) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    contributes_to acetylcholine receptor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    contributes_to acetylcholine-gated monoatomic cation-selective channel activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables acetylcholine-gated monoatomic cation-selective channel activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables excitatory extracellular ligand-gated monoatomic ion channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transmembrane signaling receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in chemical synaptic transmission IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in monoatomic cation transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in monoatomic ion transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in monoatomic ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of membrane potential IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of acetylcholine-gated channel complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of acetylcholine-gated channel complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in neuron projection IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in postsynaptic membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in synapse IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    nicotinic acetylcholine receptor alpha3
    Names
    CG2302-PB
    CG2302-PC
    Dalpha3
    drosophila alpha-like subunit 3
    nAChRalpha3-PB
    nAChRalpha3-PC
    nAcRalpha-7E
    nicotinic acetylcholine receptor alpha 7E

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      8276200..8367169 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001298086.1 → NP_001285015.1  nicotinic acetylcholine receptor alpha3, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001285015.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      O18394, Q9W3G6
      Conserved Domains (2) summary
      pfam02931
      Location:26 → 241
      Neur_chan_LBD; Neurotransmitter-gated ion-channel ligand binding domain
      pfam02932
      Location:248 → 359
      Neur_chan_memb; Neurotransmitter-gated ion-channel transmembrane region

    2. NM_080340.4 → NP_525079.3  nicotinic acetylcholine receptor alpha3, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_525079.3

      Status: REVIEWED

      UniProtKB/TrEMBL
      O18394, Q9W3G6
      Conserved Domains (2) summary
      pfam02931
      Location:26 → 241
      Neur_chan_LBD; Neurotransmitter-gated ion-channel ligand binding domain
      pfam02932
      Location:248 → 359
      Neur_chan_memb; Neurotransmitter-gated ion-channel transmembrane region
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O18394 O18394
    O44202 O44202
    Q9W3G6 Q9W3G6

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