ind intermediate neuroblasts defective [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: indprovided by FlyBase
Official Full Name: intermediate neuroblasts defectiveprovided by FlyBase
Primary source: FLYBASE:FBgn0025776
Locus tag: Dmel_CG11551
See related: AllianceGenome:FB:FBgn0025776
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG11551; Dmel\CG11551; Ind; ind/Gsx
Summary: Enables DNA-binding transcription factor activity; DNA-binding transcription factor binding activity; and sequence-specific DNA binding activity. Involved in central nervous system development; negative regulation of gene expression; and negative regulation of transcription by RNA polymerase II. Located in nucleus. Is expressed in several structures, including anlage in statu nascendi; central brain anlage; embryonic procephalic segment; ganglia; and neuroblasts. Orthologous to human GSX2 (GS homeobox 2). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 71B2-71B2; 3-42 cM

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3L	NT_037436.4 (15042799..15043924, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3L	NT_037436.3 (15035899..15037024, complement)

Chromosome 3L - NT_037436.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Conserved Gsx2/Ind homeodomain monomer versus homodimer DNA binding defines regulatory outcomes in flies and mice.
Title: Conserved Gsx2/Ind homeodomain monomer versus homodimer DNA binding defines regulatory outcomes in flies and mice.
ERK signaling during Drosophila embryogenesis, is at a stage when ERK induces transcription of intermediate neuroblasts defective (ind), a gene essential for patterning of the nerve cord.
Title: Kinetics of gene derepression by ERK signaling.
EGF signaling, acting through MAP kinase, impinges on multiple aspects of Ind regulatory activity.
Title: Phosphorylation of Ind by MAP kinase enhances Ind-dependent transcriptional repression.
cross-repression between Ind and Msh stabilizes the border between intermediate and dorsal tritocerebrum and deutocerebrum, and that both transcription factors are competent to inhibit vnd expression
Title: Role of en and novel interactions between msh, ind, and vnd in dorsoventral patterning of the Drosophila brain and ventral nerve cord.
expression is expanded ventrally in ind mutant embryos and Ind protein directly and specifically bound to the msh regulatory DNA, and this interaction was required to limit the ventral boundary of msh expression.
Title: Ind represses msh expression in the intermediate column of the Drosophila neuroectoderm, through direct interaction with upstream regulatory DNA.
The function of Ind in regulating vnd expression is one of refinement and maintenance of the dorsal border.
Title: Identification of Ind transcription activation and repression domains required for dorsoventral patterning of the CNS.
Data show that expression of gene ind is invloved in dorsoventral regionalization within the developing brain and truncal nervous system in Drosophilia.
Title: Dorsoventral patterning of the brain: a comparative approach.
These results point to conserved mechanisms used by Gsh/Ind-type homeodomain protein in regulating the expression of target genes.
Title: Conserved properties of the Drosophila homeodomain protein, Ind.
Genetic screen for regulators of ind expression identifies shrew as encoding a novel twisted gastrulation-like protein involved in Dpp signaling.
Title: Genetic screen for regulators of ind expression identifies shrew as encoding a novel twisted gastrulation-like protein involved in Dpp signaling.
Can act as a transcriptional activator; positive autoregulation of Ind is a mechanism for persistent ind expression within the developing embryonic nervous system.
Title: Identification of an upstream regulatory element reveals a novel requirement for Ind activity in maintaining ind expression.

Submit: New GeneRIF Correction See all GeneRIFs (11)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Dm1641 (e-PCR)
- UniSTS:349

Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription factor activity	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor binding	IPI Inferred from Physical Interaction more info	PubMed
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in brain development	IBA Inferred from Biological aspect of Ancestor more info
involved_in brain development	TAS Traceable Author Statement more info	PubMed
involved_in central nervous system development	IBA Inferred from Biological aspect of Ancestor more info
involved_in central nervous system development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in central nervous system development	NAS Non-traceable Author Statement more info	PubMed
involved_in dorsal/ventral pattern formation	TAS Traceable Author Statement more info	PubMed
involved_in ectoderm development	TAS Traceable Author Statement more info	PubMed
involved_in negative regulation of gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in neuron differentiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in pattern specification process	NAS Non-traceable Author Statement more info	PubMed
involved_in regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in ventral cord development	HMP more info	PubMed
involved_in ventral cord development	NAS Non-traceable Author Statement more info	PubMed
involved_in ventral cord development	TAS Traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: intermediate neuroblasts defective

Names: CG11551-PB; ind-PB; intermediate nerve cord defective; intermediate neuroblast defective

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_037436.4 Reference assembly

Range

15042799..15043924 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_206365.3 → NP_996087.2 intermediate neuroblasts defective [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_996087.2

Status: REVIEWED

UniProtKB/TrEMBL

O96620, Q7KUL4

Conserved Domains (1) summary

pfam00046
Location:231 → 283

Homeobox; Homeobox domain