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    rdgBbeta rdgBbeta [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 37011, updated on 9-Dec-2024

    Summary

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    Official Symbol
    rdgBbetaprovided by FlyBase
    Official Full Name
    rdgBbetaprovided by FlyBase
    Primary source
    FLYBASE:FBgn0027872
    Locus tag
    Dmel_CG17818
    See related
    AllianceGenome:FB:FBgn0027872
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    BcDNA.LD14189; BcDNA:LD14189; CG17818; Dmel\CG17818; DrdgBbeta; RdgB-beta; RdgBbeta; rdgbeta
    Summary
    Predicted to enable phosphatidylinositol binding activity and phosphatidylinositol transfer activity. Predicted to be involved in signal transduction. Predicted to be active in cytoplasm. Is expressed in adult head. Orthologous to human PITPNC1 (phosphatidylinositol transfer protein cytoplasmic 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See rdgBbeta in Genome Data Viewer
    Location:
    54D6-54D6; 2-83 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (17695776..17698362, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (13583281..13585867, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene Hermansky-Pudlak Syndrome 4 Neighboring gene uncharacterized protein Neighboring gene swi2 Neighboring gene antisense RNA:CR45146 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene U snoRNA host gene 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Current thoughts on the phosphatidylinositol transfer protein family. Allen-Baume V, et al. FEBS Lett, 2002 Oct 30. PMID 12401207
    2. RdgBα reciprocally transfers PA and PI at ER-PM contact sites to maintain PI(4,5)P2 homoeostasis during phospholipase C signalling in Drosophila photoreceptors. Cockcroft S, et al. Biochem Soc Trans, 2016 Feb. PMID 26862217
    3. RDGBα, a PtdIns-PtdOH transfer protein, regulates G-protein-coupled PtdIns(4,5)P2 signalling during Drosophila phototransduction. Yadav S, et al. J Cell Sci, 2015 Sep 1. PMID 26203165, Free PMC Article
    4. Cloning and characterization of a novel human phosphatidylinositol transfer protein, rdgBbeta. Fullwood Y, et al. J Biol Chem, 1999 Oct 29. PMID 10531358
    5. PI(4)P Promotes Phosphorylation and Conformational Change of Smoothened through Interaction with Its C-terminal Tail. Jiang K, et al. PLoS Biol, 2016 Feb. PMID 26863604, Free PMC Article

    See all (35) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables phosphatidylinositol binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phosphatidylinositol transfer activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phosphatidylinositol transfer activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables phospholipid transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in phospholipid transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in signal transduction ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    rdgBbeta
    Names
    CG17818-PA
    rdgBbeta-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      17695776..17698362 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_137404.5 → NP_611248.3  rdgBbeta [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_611248.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9U9P7
      Conserved Domains (1) summary
      cl14643
      Location:3 → 252
      SRPBCC; START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9U9P7.1 Q9U9P7

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