I-2 Inhibitor-2 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: I-2provided by FlyBase
Official Full Name: Inhibitor-2provided by FlyBase
Primary source: FLYBASE:FBgn0028429
Locus tag: Dmel_CG10574
See related: AllianceGenome:FB:FBgn0028429
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG10574; DI-2; Dm I-2; Dmel\CG10574; I-2Dm; I-2PP1; I2; SET
Summary: Enables protein phosphatase 1 binding activity and protein phosphatase inhibitor activity. Predicted to be involved in intracellular signal transduction. Is expressed in several structures, including adult head; cuboidal/columnar epithelium; germline cell; larval brain; and ovary. Orthologous to several human genes including PPP1R2B (PPP1R2 family member B); PPP1R2C (PPP1R2C family member C); and PPP1R2P1 (protein phosphatase 1 regulatory inhibitor subunit 2 pseudogene 1). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3L	NT_037436.4 (9834367..9836805, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3L	NT_037436.3 (9827467..9829905, complement)

Chromosome 3L - NT_037436.4 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

I-2 is required for proper chromosome segregation during Drosophila embryogenesis through the coordinated regulation of PP1 and Aurora B.
Title: Maternal phosphatase inhibitor-2 is required for proper chromosome segregation and mitotic synchrony during Drosophila embryogenesis.

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables protein phosphatase 1 binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein phosphatase inhibitor activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein phosphatase inhibitor activity	IDA Inferred from Direct Assay more info	PubMed
enables protein phosphatase inhibitor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in intracellular signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of BMP signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of signal transduction	IEA Inferred from Electronic Annotation more info

Names: CG10574-PA; CG10574-PB; I-2-PA; I-2-PB; inhibitor-2; phosphatase inhibitor-2

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The following sections contain reference sequences that belong to a specific genome build. Explain