Cdc7 Cdc7 kinase [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Cdc7provided by FlyBase
Official Full Name: Cdc7 kinaseprovided by FlyBase
Primary source: FLYBASE:FBgn0028360
Locus tag: Dmel_CG32742
See related: AllianceGenome:FB:FBgn0028360
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: anon-WO03040301.250; cdc7; cdc7-related; CG32742; CG8655; CG8656; CT25076; Dmel\CG32742; l(1)G0148; L(1)G0148; l(1)G0149; l(1)G0461
Summary: Enables histone kinase activity. Involved in several processes, including eggshell chorion gene amplification; endomitotic cell cycle; and positive regulation of DNA replication. Located in nucleus. Part of Dbf4-dependent protein kinase complex. Orthologous to human CDC7 (cell division cycle 7). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 6C3-6C3; 1-18 cM

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	X	NC_004354.4 (6654541..6659709)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	X	NC_004354.3 (6548574..6553742)

Chromosome X - NC_004354.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

the genetic or pharmacological inhibition of CDC7 results in increased expression of the collagen endocytic receptor Endo180. Chromobox 5 (CBX5) is a putative target of CDC7, and genetic silencing of CBX5 also results in increased Endo180 and collagen uptake.
Title: Cell division cycle 7 kinase is a negative regulator of cell-mediated collagen degradation.
Cdc7 has a role in endoreplication independent of Chiffon in Drosophila
Title: Characterization of a Drosophila ortholog of the Cdc7 kinase: a role for Cdc7 in endoreplication independent of Chiffon.

Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables histone kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein serine/threonine kinase activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed

Process	Evidence Code	Pubs
involved_in eggshell chorion gene amplification	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in embryonic development via the syncytial blastoderm	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in endomitotic cell cycle	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mitotic DNA damage checkpoint signaling	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of DNA replication	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein phosphorylation	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of Dbf4-dependent protein kinase complex	IDA Inferred from Direct Assay more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info	PubMed

General protein information

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Preferred Names: Cdc7 kinase

Names: CG32742-PA; CG32742-PB; Cdc7-PA; Cdc7-PB; lethal (1) G0148

NP_001284950.1

EC 2.7.11.1

NP_727103.1

EC 2.7.11.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_004354.4 Reference assembly

Range

6654541..6659709

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_167080.2 → NP_727103.1 Cdc7 kinase, isoform A [Drosophila melanogaster]

Status: REVIEWED

UniProtKB/TrEMBL

Q3KN27, Q9W3Y1

Related

FBpp0070911

Conserved Domains (2) summary

cd14019
Location:125 → 644

STKc_Cdc7; Catalytic domain of the Serine/Threonine Kinase, Cell Division Cycle 7 kinase

cl21453
Location:474 → 644

PKc_like; Protein Kinases, catalytic domain
NM_001298021.1 → NP_001284950.1 Cdc7 kinase, isoform B [Drosophila melanogaster]

Status: REVIEWED

UniProtKB/TrEMBL

Q3KN27, X2JCT3

Conserved Domains (2) summary

cd14019
Location:124 → 643

STKc_Cdc7; Catalytic domain of the Serine/Threonine Kinase, Cell Division Cycle 7 kinase

cl21453
Location:473 → 643

PKc_like; Protein Kinases, catalytic domain