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    Myo10A Myosin 10A [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 32028, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Myo10Aprovided by FlyBase
    Official Full Name
    Myosin 10Aprovided by FlyBase
    Primary source
    FLYBASE:FBgn0263705
    Locus tag
    Dmel_CG43657
    See related
    AllianceGenome:FB:FBgn0263705
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    10A; AAF47980; CG16922; CG2136; CG2174; CG43657; Dmel\CG43657; DmXV; myo10A; Myo20; Syph
    Old locus tag
    Dmel_CG16922; Dmel_CG2174
    Summary
    Predicted to enable actin filament binding activity and microfilament motor activity. Involved in dorsal closure; filopodium assembly; and intracellular protein transport. Located in filopodium and neuronal cell body. Is expressed in adult brain cell body rind; adult head; lamina; and spermatozoon. Human ortholog(s) of this gene implicated in autosomal recessive nonsyndromic deafness 3 and sensorineural hearing loss. Orthologous to human MYO15A (myosin XVA). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Myo10A in Genome Data Viewer
    Location:
    9F12-9F13; 1-33 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (10930840..10964046)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (10824873..10858079)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene vermilion Neighboring gene Rab at 9Fa Neighboring gene Rab at 9Fb Neighboring gene C901 Neighboring gene vexed Neighboring gene SET and MYND domain containing, arthropod-specific, member 4

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Myosin XV is a negative regulator of signaling filopodia during long-range lateral inhibition. Clements R, et al. Dev Biol, 2024 Jan. PMID 37956923,
    2. Adhesion and Fusion of Muscle Cells Are Promoted by Filopodia. Segal D, et al. Dev Cell, 2016 Aug 8. PMID 27505416
    3. Molecular to organismal chirality is induced by the conserved myosin 1D. Lebreton G, et al. Science, 2018 Nov 23. PMID 30467170, Free PMC Article
    4. How to make a curved Drosophila bristle using straight actin bundles. Tilney LG, et al. Proc Natl Acad Sci U S A, 2005 Dec 27. PMID 16357198, Free PMC Article
    5. Rapidly evolving Rab GTPase paralogs and reproductive isolation in Drosophila. Hutter P. Adv Genet, 2007. PMID 17452244

    See all (54) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Myosin XV is a negative regulator of signaling filopodia during long-range lateral inhibition.
      Title: Myosin XV is a negative regulator of signaling filopodia during long-range lateral inhibition.
    2. suggest a mechanism for Sisyphus (the Drosophila myosin XV homolog) in which it maintains a balance between actin and microtubule cytoskeleton components
      Title: Sisyphus, the Drosophila myosin XV homolog, traffics within filopodia transporting key sensory and adhesion cargos.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    mobile_element

    • Loc: 10939862-10939928 mobile_element_type = transposon:INE-1{}5845

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables actin filament binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cytoskeletal motor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables microfilament motor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in actin filament organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in dorsal closure IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in endocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in filopodium assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in intracellular protein transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in actin cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in actin-based cell projection IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in filopodium IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of myosin complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in neuronal cell body IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    myosin 10A
    Names
    CG43657-PC
    CG43657-PD
    CG43657-PE
    CG43657-PF
    Myo10A-PC
    Myo10A-PD
    Myo10A-PE
    Myo10A-PF
    myosin XV
    sisyphus
    unconventional myosin class XV
    NP_001036269.2
    NP_001259435.1
    NP_001285103.1
    NP_572669.2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      10930840..10964046
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001298174.1 → NP_001285103.1  myosin 10A, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001285103.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VZ45
      Conserved Domains (7) summary
      smart00242
      Location:65 → 745
      MYSc; Myosin. Large ATPases
      smart00295
      Location:2732 → 2942
      B41; Band 4.1 homologues
      cd13201
      Location:2938 → 3047
      FERM_C_MyoXV; FERM domain C-lobe of Myosin XV (MyoXV/Myo15)
      cd14473
      Location:2829 → 2934
      FERM_B-lobe; FERM domain B-lobe
      cd01387
      Location:78 → 737
      MYSc_Myo15; class XV mammal-like myosin, motor domain
      pfam00784
      Location:2613 → 2719
      MyTH4; MyTH4 domain
      cl02480
      Location:923 → 1080
      MyTH4; MyTH4 domain

    2. NM_001042804.3 → NP_001036269.2  myosin 10A, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001036269.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q0KHU0
      Conserved Domains (7) summary
      smart00242
      Location:156 → 836
      MYSc; Myosin. Large ATPases
      smart00295
      Location:2823 → 3033
      B41; Band 4.1 homologues
      cd13201
      Location:3029 → 3138
      FERM_C_MyoXV; FERM domain C-lobe of Myosin XV (MyoXV/Myo15)
      cd14473
      Location:2920 → 3025
      FERM_B-lobe; FERM domain B-lobe
      cd01387
      Location:169 → 828
      MYSc_Myo15; class XV mammal-like myosin, motor domain
      pfam00784
      Location:2704 → 2810
      MyTH4; MyTH4 domain
      cl02480
      Location:1014 → 1171
      MyTH4; MyTH4 domain

    3. NM_132441.3 → NP_572669.2  myosin 10A, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_572669.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VZ45
      Conserved Domains (7) summary
      smart00242
      Location:65 → 745
      MYSc; Myosin. Large ATPases
      smart00295
      Location:2732 → 2942
      B41; Band 4.1 homologues
      cd13201
      Location:2938 → 3047
      FERM_C_MyoXV; FERM domain C-lobe of Myosin XV (MyoXV/Myo15)
      cd14473
      Location:2829 → 2934
      FERM_B-lobe; FERM domain B-lobe
      cd01387
      Location:78 → 737
      MYSc_Myo15; class XV mammal-like myosin, motor domain
      pfam00784
      Location:2613 → 2719
      MyTH4; MyTH4 domain
      cl02480
      Location:923 → 1080
      MyTH4; MyTH4 domain

    4. NM_001272506.1 → NP_001259435.1  myosin 10A, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001259435.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PGV5
      Conserved Domains (4) summary
      smart00295
      Location:747 → 957
      B41; Band 4.1 homologues
      cd13201
      Location:953 → 1062
      FERM_C_MyoXV; FERM domain C-lobe of Myosin XV (MyoXV/Myo15)
      cd14473
      Location:844 → 949
      FERM_B-lobe; FERM domain B-lobe
      pfam00784
      Location:628 → 734
      MyTH4; MyTH4 domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    M9PGV5 M9PGV5
    Q0KHU0 Q0KHU0
    Q8T6M1 Q8T6M1
    Q9VZ45 Q9VZ45

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