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    Ir10a Ionotropic receptor 10a [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 32067, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Ir10aprovided by FlyBase
    Official Full Name
    Ionotropic receptor 10aprovided by FlyBase
    Primary source
    FLYBASE:FBgn0083979
    Locus tag
    Dmel_CG34143
    See related
    AllianceGenome:FB:FBgn0083979
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    10a; CG12623; CG12624; CG34143; DmelIR10a; Dmel\CG34143; IR10a
    Summary
    Predicted to enable ligand-gated monoatomic ion channel activity. Predicted to be involved in detection of chemical stimulus. Predicted to be located in membrane. Is expressed in adult abdomen; dorsal cibarial sense organ neurons; larval abdomen; and wing. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Ir10a in Genome Data Viewer
    Location:
    10B2-10B2; 1-34 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (11308533..11311208, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (11202566..11205241, complement)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene lethal (1) 10Bb Neighboring gene sisterless A

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Revisiting the protein-coding gene catalog of Drosophila melanogaster using 12 fly genomes. Lin MF, et al. Genome Res, 2007 Dec. PMID 17989253, Free PMC Article
    2. Retroactive, a membrane-anchored extracellular protein related to vertebrate snake neurotoxin-like proteins, is required for cuticle organization in the larva of Drosophila melanogaster. Moussian B, et al. Dev Dyn, 2005 Jul. PMID 15844167
    3. A single pair of pharyngeal neurons functions as a commander to reject high salt in Drosophila melanogaster. Sang J, et al. Elife, 2024 Apr 4. PMID 38573740, Free PMC Article
    4. The sexual identity of adult intestinal stem cells controls organ size and plasticity. Hudry B, et al. Nature, 2016 Feb 18. PMID 26887495, Free PMC Article
    5. Avoiding cantharidin through ionotropic receptors. Pradhan RN, et al. J Hazard Mater, 2024 Mar 15. PMID 38278077

    See all (32) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ligand-gated monoatomic ion channel activity ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in detection of chemical stimulus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in membrane ISM
    Inferred from Sequence Model
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    ionotropic receptor 10a
    Names
    CG34143-PC
    Ir10a-PC
    NP_001096949.1
    • deletion mutation, may be evolving pseudogene

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      11308533..11311208 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001103479.1 → NP_001096949.1  ionotropic receptor 10a [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A8JUR3
      Conserved Domains (3) summary
      pfam00060
      Location:319 → 587
      Lig_chan; Ligand-gated ion channel
      cl00454
      Location:315 → 411
      TM_PBP1_branched-chain-AA_like; Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of ...
      cl21456
      Location:220 → 294
      Periplasmic_Binding_Protein_Type_2; Type 2 periplasmic binding fold superfamily
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A8JUR3 A8JUR3

    Gene LinkOut

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    Other Literature Sources
    Molecular Biology Databases
    Research Materials