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    Pkcdelta Protein kinase C delta [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 32191, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Pkcdeltaprovided by FlyBase
    Official Full Name
    Protein kinase C deltaprovided by FlyBase
    Primary source
    FLYBASE:FBgn0287828
    Locus tag
    Dmel_CG42349
    See related
    AllianceGenome:FB:FBgn0287828
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG10524; CG11245; CG42349; delta PKC; Dmel\CG42349; mfd; PKCd; PKCdelta
    Old locus tag
    Dmel_CG10524; Dmel_CG11245
    Summary
    Enables myosin light chain kinase activity. Involved in flight. Predicted to be located in plasma membrane. Is expressed in adult brain. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Pkcdelta in Genome Data Viewer
    Location:
    11A10-11A11; 1-38 cM
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (12432224..12453650)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (12326257..12347683)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR32652 Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR45615 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Protein kinase C delta (PKCdelta) is required for protein tyrosine phosphatase mu (PTPmu)-dependent neurite outgrowth. Rosdahl JA, et al. Mol Cell Neurosci, 2002 Feb. PMID 11860281
    2. Statins Induce Locomotion and Muscular Phenotypes in Drosophila melanogaster That Are Reminiscent of Human Myopathy: Evidence for the Role of the Chloride Channel Inhibition in the Muscular Phenotypes. Al-Sabri MH, et al. Cells, 2022 Nov 8. PMID 36428957, Free PMC Article
    3. Regulation of Drosophila myosin ATPase activity by phosphorylation of myosin light chains--II. Flightless mfd- fly. Takahashi S, et al. Comp Biochem Physiol B, 1990. PMID 2139598
    4. PKC in motorneurons underlies self-learning, a form of motor learning in Drosophila. Colomb J, et al. PeerJ, 2016. PMID 27168980, Free PMC Article
    5. PKC98E Regulates Odorant Responses in Drosophila melanogaster. Poudel S, et al. J Neurosci, 2021 May 5. PMID 33789918, Free PMC Article

    See all (51) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. PTPmu signaling via RACK1 requires PKCdelta activity to promote neurite outgrowth in chick retinal ganglion cells.
      Title: Protein kinase C delta (PKCdelta) is required for protein tyrosine phosphatase mu (PTPmu)-dependent neurite outgrowth.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables diacylglycerol-dependent serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables myosin light chain kinase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in flight IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in intracellular signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    protein kinase C delta
    Names
    CG42349-PC
    CG42349-PD
    CG42349-PE
    Pkcdelta-PC
    Pkcdelta-PD
    Pkcdelta-PE
    myofibrillar defect
    protein kinase C
    NP_001138191.1
    NP_511171.3
    NP_572797.3

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      12432224..12453650
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_078616.4 → NP_511171.3  protein kinase C delta, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_511171.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P83099, Q5BIE9, Q9VYN2
      UniProtKB/TrEMBL
      B7Z147
      Conserved Domains (3) summary
      smart00220
      Location:343 → 601
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd05592
      Location:347 → 666
      STKc_nPKC_theta_like; Catalytic domain of the Serine/Threonine Kinases, Novel Protein Kinase C theta, delta, and similar proteins
      pfam00130
      Location:217 → 269
      C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)

    2. NM_001144719.2 → NP_001138191.1  protein kinase C delta, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001138191.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P83099, Q5BIE9, Q9VYN2
      UniProtKB/TrEMBL
      B7Z147
      Conserved Domains (3) summary
      smart00220
      Location:343 → 601
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd05592
      Location:347 → 666
      STKc_nPKC_theta_like; Catalytic domain of the Serine/Threonine Kinases, Novel Protein Kinase C theta, delta, and similar proteins
      pfam00130
      Location:217 → 269
      C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)

    3. NM_132569.3 → NP_572797.3  protein kinase C delta, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_572797.3

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VYN1
      Conserved Domains (2) summary
      cd05592
      Location:1570 → 1889
      STKc_nPKC_theta_like; Catalytic domain of the Serine/Threonine Kinases, Novel Protein Kinase C theta, delta, and similar proteins
      pfam05109
      Location:802 → 1131
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    B7Z147 B7Z147
    P83099.3 P83099
    Q9VYN1 Q9VYN1

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