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    Rab40 Rab40 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 32195, updated on 9-Dec-2024

    Summary

    Official Symbol
    Rab40provided by FlyBase
    Official Full Name
    Rab40provided by FlyBase
    Primary source
    FLYBASE:FBgn0030391
    Locus tag
    Dmel_CG1900
    See related
    AllianceGenome:FB:FBgn0030391
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    24641533; CG1900; Dmel\CG1900; DmRab40; Q8IR80; rab40
    Summary
    Enables GTPase activity. Involved in Golgi organization. Acts upstream of with a positive effect on lipophagy. Located in cytosol. Colocalizes with Golgi apparatus and lipid droplet. Is expressed in larval ventral nerve cord. Orthologous to several human genes including RAB40C (RAB40C, member RAS oncogene family). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
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    Genomic context

    See Rab40 in Genome Data Viewer
    Location:
    11A11-11A11; 1-38 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (12459796..12463112, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (12353829..12357145, complement)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR45615 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Cuticular protein 11A

    Genomic regions, transcripts, and products

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables GTPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables GTPase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables GTPase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables GTPase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Process Evidence Code Pubs
    involved_in Golgi organization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in Rab protein signal transduction ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in exocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in intracellular signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_positive_effect lipophagy IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in vesicle-mediated transport ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    colocalizes_with Golgi apparatus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in endosome IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    colocalizes_with lipid droplet IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in synaptic vesicle IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in vesicle ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    Rab40
    Names
    CG1900-PA
    CG1900-PB
    CG1900-PC
    Rab40-PA
    Rab40-PB
    Rab40-PC

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      12459796..12463112 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_132572.3NP_572800.2  Rab40, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_572800.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q95RQ2, Q9VYM8
      Related
      FBpp0073501
      Conserved Domains (3) summary
      cd04121
      Location:6255
      Rab40; Rab GTPase family 40 (Rab40) contains Rab40a, Rab40b and Rab40c
      smart00175
      Location:12172
      RAB; Rab subfamily of small GTPases
      cl02533
      Location:182224
      SOCS; SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region of CIS/SOCS family proteins (in combination with a SH2 domain), ASBs (ankyrin repeat-containing proteins with a SOCS box), SSBs (SPRY domain-containing proteins ...
    2. NM_167323.2NP_727611.1  Rab40, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_727611.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8IR80, Q95RQ2
      Related
      FBpp0073502
      Conserved Domains (3) summary
      smart00175
      Location:12182
      RAB; Rab subfamily of small GTPases
      cl02533
      Location:192234
      SOCS; SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region of CIS/SOCS family proteins (in combination with a SH2 domain), ASBs (ankyrin repeat-containing proteins with a SOCS box), SSBs (SPRY domain-containing proteins ...
      cl21455
      Location:6265
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
    3. NM_001298224.1NP_001285153.1  Rab40, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001285153.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q95RQ2, Q9VYM8
      Conserved Domains (3) summary
      cd04121
      Location:6255
      Rab40; Rab GTPase family 40 (Rab40) contains Rab40a, Rab40b and Rab40c
      smart00175
      Location:12172
      RAB; Rab subfamily of small GTPases
      cl02533
      Location:182224
      SOCS; SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region of CIS/SOCS family proteins (in combination with a SH2 domain), ASBs (ankyrin repeat-containing proteins with a SOCS box), SSBs (SPRY domain-containing proteins ...