U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Sec61gamma Sec61 gamma subunit [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 32968, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    Sec61gammaprovided by FlyBase
    Official Full Name
    Sec61 gamma subunitprovided by FlyBase
    Primary source
    FLYBASE:FBgn0031049
    Locus tag
    Dmel_CG14214
    See related
    AllianceGenome:FB:FBgn0031049
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG14214; Dmel\CG14214; Sec61
    Summary
    Predicted to enable protein transmembrane transporter activity. Involved in negative regulation of autophagy. Predicted to be located in membrane. Predicted to be part of Sec61 translocon complex and Ssh1 translocon complex. Orthologous to human SEC61G (SEC61 translocon subunit gamma). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See Sec61gamma in Genome Data Viewer
    Location:
    18D11-18D12; 1-63 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (19643327..19644518)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (19537360..19538551)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene Required for cell differentiation 1 Neighboring gene uncharacterized protein Neighboring gene Actin-related protein 10 Neighboring gene Ranbp21

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Identification of NUB1 as a suppressor of mutant Huntington toxicity via enhanced protein clearance. Lu B, et al. Nat Neurosci, 2013 May. PMID 23525043
    2. Multiple classes of MSL binding sites target dosage compensation to the X chromosome of Drosophila. Oh H, et al. Curr Biol, 2004 Mar 23. PMID 15043812
    3. Genome-wide RNAi screen of Ca(2+) influx identifies genes that regulate Ca(2+) release-activated Ca(2+) channel activity. Zhang SL, et al. Proc Natl Acad Sci U S A, 2006 Jun 13. PMID 16751269, Free PMC Article
    4. A genetic screen in Drosophila reveals novel cytoprotective functions of the autophagy-lysosome pathway. Arsham AM, et al. PLoS One, 2009 Jun 29. PMID 19562034, Free PMC Article
    5. EDEM Function in ERAD Protects against Chronic ER Proteinopathy and Age-Related Physiological Decline in Drosophila. Sekiya M, et al. Dev Cell, 2017 Jun 19. PMID 28633019, Free PMC Article

    See all (39) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables protein transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in SRP-dependent cotranslational protein targeting to membrane, translocation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in intracellular protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of autophagy IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in post-translational protein targeting to membrane, translocation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein targeting IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of Sec61 translocon complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    part_of Ssh1 translocon complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    Sec61 gamma subunit
    Names
    CG14214-PA
    CG14214-PB
    CG14214-PC
    Sec61gamma-PA
    Sec61gamma-PB
    Sec61gamma-PC

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      19643327..19644518
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001298521.1 → NP_001285450.1  Sec61 gamma subunit, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001285450.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9VWE9
      UniProtKB/TrEMBL
      X2JCL6
      Conserved Domains (1) summary
      cl00481
      Location:12 → 68
      SecE; SecE/Sec61-gamma subunits of protein translocation complex

    2. NM_134493.3 → NP_608337.1  Sec61 gamma subunit, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_608337.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9VWE9
      UniProtKB/TrEMBL
      X2JCL6
      Related
      FBpp0074514
      Conserved Domains (1) summary
      cl00481
      Location:12 → 68
      SecE; SecE/Sec61-gamma subunits of protein translocation complex

    3. NM_001298522.1 → NP_001285451.1  Sec61 gamma subunit, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001285451.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9VWE9
      UniProtKB/TrEMBL
      X2JCL6
      Conserved Domains (1) summary
      cl00481
      Location:12 → 68
      SecE; SecE/Sec61-gamma subunits of protein translocation complex
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VWE9.1 Q9VWE9
    X2JCL6 X2JCL6

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous