shakB shaking B [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: shakBprovided by FlyBase
Official Full Name: shaking Bprovided by FlyBase
Primary source: FLYBASE:FBgn0085387
Locus tag: Dmel_CG34358
See related: AllianceGenome:FB:FBgn0085387
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: 2; 3; 6; CG12678; CG1321; CG15451; CG32508; CG34358; Dmel\CG34358; E81; FBpp0111481; inx8; Inx8; l(1)19Eb; l(1)LB21; l(1)R-10-14; l(1)R-10-3; l(1)R-10-7; l(1)R-9-29; l(1)TH73; l(1)W3; l(1)W3b; lincRNA.1031; nj-156; nj156; pas; Pas; pass; R-9-29; R9-29; Shak B; shak-B; Shak-B; SHAK-B; ShakB; shB; shkB; W3
Old locus tag: CG12678; CG32508; Dmel_CG12678; Dmel_CG32508
Summary: Enables gap junction channel activity and photoreceptor activity. Involved in several processes, including gap junction assembly; jump response; and phototransduction. Located in gap junction and plasma membrane. Is expressed in several structures, including ISN innervated muscle cell of A1-7; adult head; efferent neurons; ganglia; and midgut primordium. [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 19E2-19E5; 1-65 cM

Exon count:: 18

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	X	NC_004354.4 (20761071..20927050, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	X	NC_004354.3 (20632098..20798077, complement)

Chromosome X - NC_004354.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Misexpression of ShakB did not increase these parameters. Immunostaining showed no association between presynaptic active zones and the new ShakB plaques.
Title: Shaking-B misexpression increases the formation of gap junctions but not chemical synapses between auditory sensory neurons and the giant fiber of Drosophila melanogaster.
Overexpression of ShakB(N+16) in JONs caused the formation of ectopic dye coupling
Title: Shaking B Mediates Synaptic Coupling between Auditory Sensory Neurons and the Giant Fiber of Drosophila melanogaster.
Tryptophan scanning was used to probe the first transmembrane domain (M1) of the Drosophila innexin Shaking-B(Lethal).
Title: Tryptophan scanning mutagenesis of the first transmembrane domain of the innexin Shaking-B(Lethal).
The escape response is impaired in ShakB2 mutants, but they displayed normal voluntary flight initiation. The escape mechanism is subject to developmental modulation following eclosion and the GF system does not underlie voluntary flight.
Title: Ontogeny of flight initiation in the fly Drosophila melanogaster: implications for the giant fibre system.
Data show that innexins, including shakB and ogre, are not functionally interchangeable in Drosophila during photoreceptor development.
Title: Gap junction proteins are not interchangeable in development of neural function in the Drosophila visual system.
Seizures caused by bang-sensitive (bas2) and bang-senseless (bss1, bss2 alleles) mutations are not suppressed by shakB2
Title: Seizure suppression by shakB2, a gap junction mutation in Drosophila.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Dm2155 (e-PCR)
- UniSTS:16961

Dm1905 (e-PCR)
- UniSTS:862

NoName (e-PCR)
- UniSTS:98954

Homology

NCBI Orthologs

Orthologs from OrthoDB

mobile_element

Loc: c20777807-20777766 mobile_element_type = transposon:INE-1{}5531
Loc: c20783281-20782766 mobile_element_type = transposon:INE-1{}5533
Loc: c20806472-20806130 mobile_element_type = transposon:INE-1{}5535
Loc: c20857088-20856882 mobile_element_type = transposon:INE-1{}5539
Loc: c20859803-20859728 mobile_element_type = transposon:gypsy12{}5557
Loc: c20880618-20880125 mobile_element_type = transposon:INE-1{}5541
Loc: c20895045-20894781 mobile_element_type = transposon:INE-1{}5545

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables gap junction channel activity	IBA Inferred from Biological aspect of Ancestor more info
enables gap junction channel activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables photoreceptor activity	IMP Inferred from Mutant Phenotype more info	PubMed

Process	Evidence Code	Pubs
involved_in cell communication by electrical coupling	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in gap junction assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in intercellular transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in jump response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in phototransduction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of membrane depolarization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to light stimulus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in transmembrane transport	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in gap junction	IBA Inferred from Biological aspect of Ancestor more info
located_in gap junction	IDA Inferred from Direct Assay more info	PubMed
located_in gap junction	IMP Inferred from Mutant Phenotype more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: shaking B

Names: CG34358-PA; CG34358-PC; CG34358-PD; CG34358-PE; CG34358-PF; CG34358-PG; CG34358-PH; CG34358-PI; Shaking-B; non-jumper-156; passover; passover-vital protein; section 2; section 3; section 6; shakB-PA; shakB-PC; shakB-PD; shakB-PE; shakB-PF; shakB-PG; shakB-PH; shakB-PI; shakingB