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    Rbp9 RNA-binding protein 9 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 33498, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Rbp9provided by FlyBase
    Official Full Name
    RNA-binding protein 9provided by FlyBase
    Primary source
    FLYBASE:FBgn0010263
    Locus tag
    Dmel_CG3151
    See related
    AllianceGenome:FB:FBgn0010263
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG15402; CG3151; Dmel\CG3151; fes; fs(2)B; rbp; Rbp10; rbp9; RBP9; RBP9-2; rbp9a; Rpb9; rrm10; RRM10; rrm9; RRM9
    Summary
    Predicted to enable mRNA binding activity. Involved in establishment of blood-brain barrier; germ cell proliferation; and oogenesis. Is active in cytoplasmic ribonucleoprotein granule. Is expressed in several structures, including adult brain; adult central nervous system; adult ventral nerve cord; female germline cell; and organism subdivision. Orthologous to several human genes including ELAVL2 (ELAV like RNA binding protein 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Rbp9 in Genome Data Viewer
    Location:
    23C3-23C3; 2-8 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (2954762..2968434)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (2954762..2968434)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene Rab geranylgeranyltransferase subunit beta Neighboring gene NTPase Neighboring gene lilliputian Neighboring gene gamma-Tubulin at 23C Neighboring gene Recombination repair protein 1 Neighboring gene Thymidylate synthase

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Sexual behaviour of a female sterile mutant of Drosophila melanogaster. Cook R, et al. J Insect Physiol, 1976. PMID 827588
    2. Expression of Rbp9 during mid-oogenesis induces apoptosis in egg chambers. Jeong K, et al. Mol Cells, 2003 Dec 31. PMID 14744031
    3. STUDIES ON THE FES MUTANT OF DROSOPHILA MELANOGASTER. KOCH EA, et al. Growth, 1964 Dec. PMID 14247613
    4. The hereditary ovarian tumors of the fes mutant of Drosophila melanogaster. KING RC, et al. Exp Cell Res, 1961 Feb. PMID 13756101
    5. The effect of temperature upon the ovarian tumors of the fes mutant of Drosophila melanogaster. KING RC, et al. Growth, 1961 Mar. PMID 13756100

    See all (114) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. mutations are associated with blood-brain barrier defects
      Title: Blood-brain barrier defects associated with Rbp9 mutation.
    2. Study shows that the antimicrobial peptide, Attacin, is upregulated in Rbp9 mutants, especially in ovaries where tumors form.
      Title: Ovarian tumors in Rbp9 mutants of Drosophila induce an immune response.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables mRNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables mRNA binding NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in establishment of blood-brain barrier IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in germ cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in oogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasmic ribonucleoprotein granule IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus TAS
    Traceable Author Statement
    more info
    		 PubMed 
    part_of ribonucleoprotein complex IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    RNA-binding protein 9
    Names
    CG3151-PB
    CG3151-PC
    CG3151-PE
    CG3151-PF
    CG3151-PG
    CG3151-PH
    CG3151-PI
    CG3151-PJ
    CG3151-PK
    RNA binding protein 9
    RNA-binding protein 10
    Rbp9-PB
    Rbp9-PC
    Rbp9-PE
    Rbp9-PF
    Rbp9-PG
    Rbp9-PH
    Rbp9-PI
    Rbp9-PJ
    Rbp9-PK
    arrest
    female sterile
    female sterile (2) bridges
    female sterile(2)Bridges

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      2954762..2968434
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_057589.3 → NP_476937.3  RNA-binding protein 9, isoform I [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_476937.3

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q24473, Q7KU23, Q9VQJ0
      Conserved Domains (4) summary
      cd12377
      Location:360 → 437
      RRM3_Hu; RNA recognition motif 3 in the Hu proteins family
      cd12650
      Location:109 → 186
      RRM1_Hu; RNA recognition motif 1 in the Hu proteins family
      cd12652
      Location:196 → 279
      RRM2_Hu; RNA recognition motif 2 in the Hu proteins family
      TIGR01661
      Location:107 → 443
      ELAV_HUD_SF; ELAV/HuD family splicing factor

    2. NM_057588.3 → NP_476936.3  RNA-binding protein 9, isoform H [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_476936.3

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q24474, Q7KU26
      Conserved Domains (4) summary
      cd12377
      Location:355 → 432
      RRM3_Hu; RNA recognition motif 3 in the Hu proteins family
      cd12650
      Location:109 → 186
      RRM1_Hu; RNA recognition motif 1 in the Hu proteins family
      cd12652
      Location:196 → 274
      RRM2_Hu; RNA recognition motif 2 in the Hu proteins family
      TIGR01661
      Location:107 → 438
      ELAV_HUD_SF; ELAV/HuD family splicing factor

    3. NM_001014462.3 → NP_001014462.1  RNA-binding protein 9, isoform G [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001014462.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q24474, Q7KU26
      Conserved Domains (4) summary
      cd12377
      Location:355 → 432
      RRM3_Hu; RNA recognition motif 3 in the Hu proteins family
      cd12650
      Location:109 → 186
      RRM1_Hu; RNA recognition motif 1 in the Hu proteins family
      cd12652
      Location:196 → 274
      RRM2_Hu; RNA recognition motif 2 in the Hu proteins family
      TIGR01661
      Location:107 → 438
      ELAV_HUD_SF; ELAV/HuD family splicing factor

    4. NM_134297.5 → NP_599124.1  RNA-binding protein 9, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_599124.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q24473, Q7KU23, Q9VQJ0
      Related
      FBpp0077322
      Conserved Domains (4) summary
      cd12377
      Location:360 → 437
      RRM3_Hu; RNA recognition motif 3 in the Hu proteins family
      cd12650
      Location:109 → 186
      RRM1_Hu; RNA recognition motif 1 in the Hu proteins family
      cd12652
      Location:196 → 279
      RRM2_Hu; RNA recognition motif 2 in the Hu proteins family
      TIGR01661
      Location:107 → 443
      ELAV_HUD_SF; ELAV/HuD family splicing factor

    5. NM_134298.5 → NP_599125.1  RNA-binding protein 9, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_599125.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q24474, Q7KU26
      Related
      FBpp0077323
      Conserved Domains (4) summary
      cd12377
      Location:355 → 432
      RRM3_Hu; RNA recognition motif 3 in the Hu proteins family
      cd12650
      Location:109 → 186
      RRM1_Hu; RNA recognition motif 1 in the Hu proteins family
      cd12652
      Location:196 → 274
      RRM2_Hu; RNA recognition motif 2 in the Hu proteins family
      TIGR01661
      Location:107 → 438
      ELAV_HUD_SF; ELAV/HuD family splicing factor

    6. NM_001273045.1 → NP_001259974.1  RNA-binding protein 9, isoform J [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001259974.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PBZ2
      Conserved Domains (4) summary
      cd12377
      Location:355 → 432
      RRM3_Hu; RNA recognition motif 3 in the Hu proteins family
      cd12650
      Location:109 → 186
      RRM1_Hu; RNA recognition motif 1 in the Hu proteins family
      cd12652
      Location:196 → 274
      RRM2_Hu; RNA recognition motif 2 in the Hu proteins family
      TIGR01661
      Location:107 → 438
      ELAV_HUD_SF; ELAV/HuD family splicing factor

    7. NM_134300.4 → NP_599127.1  RNA-binding protein 9, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_599127.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q24473, Q7KU23, Q9VQJ0
      Related
      FBpp0077324
      Conserved Domains (4) summary
      cd12377
      Location:360 → 437
      RRM3_Hu; RNA recognition motif 3 in the Hu proteins family
      cd12650
      Location:109 → 186
      RRM1_Hu; RNA recognition motif 1 in the Hu proteins family
      cd12652
      Location:196 → 279
      RRM2_Hu; RNA recognition motif 2 in the Hu proteins family
      TIGR01661
      Location:107 → 443
      ELAV_HUD_SF; ELAV/HuD family splicing factor

    8. NM_134299.5 → NP_599126.1  RNA-binding protein 9, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_599126.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q24474, Q7KU26
      Related
      FBpp0077325
      Conserved Domains (4) summary
      cd12377
      Location:355 → 432
      RRM3_Hu; RNA recognition motif 3 in the Hu proteins family
      cd12650
      Location:109 → 186
      RRM1_Hu; RNA recognition motif 1 in the Hu proteins family
      cd12652
      Location:196 → 274
      RRM2_Hu; RNA recognition motif 2 in the Hu proteins family
      TIGR01661
      Location:107 → 438
      ELAV_HUD_SF; ELAV/HuD family splicing factor

    9. NM_001298640.1 → NP_001285569.1  RNA-binding protein 9, isoform K [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001285569.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q24473, Q7KU23, Q9VQJ0
      Conserved Domains (4) summary
      cd12377
      Location:360 → 437
      RRM3_Hu; RNA recognition motif 3 in the Hu proteins family
      cd12650
      Location:109 → 186
      RRM1_Hu; RNA recognition motif 1 in the Hu proteins family
      cd12652
      Location:196 → 279
      RRM2_Hu; RNA recognition motif 2 in the Hu proteins family
      TIGR01661
      Location:107 → 443
      ELAV_HUD_SF; ELAV/HuD family splicing factor
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    M9PBZ2 M9PBZ2
    Q24474 Q24474
    Q26278 Q26278
    Q26279 Q26279
    Q26293 Q26293
    Q95TA9 Q95TA9
    Q9VQJ0 Q9VQJ0

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